Motif ID: Hoxd8

Z-value: 0.580


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_80165013 5.617 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr9_+_80165079 4.109 ENSMUST00000184480.1
 Myo6
myosin VI
chr2_+_83724397 3.955 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
 Itgav


integrin alpha V


chr1_-_138848576 3.654 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr3_+_127633134 3.549 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr3_+_76075583 3.451 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr6_+_34384218 3.130 ENSMUST00000038383.7
ENSMUST00000115051.1
 Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr1_+_9547948 2.830 ENSMUST00000144177.1
 Adhfe1
alcohol dehydrogenase, iron containing, 1
chr19_+_23723279 2.546 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr3_+_94372794 2.545 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr6_+_71282280 2.497 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr18_+_11633276 2.463 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr5_-_62766153 2.211 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_35155750 1.990 ENSMUST00000067033.7
ENSMUST00000018476.7
 Stk3

serine/threonine kinase 3

chr12_-_84617326 1.830 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr5_-_111761697 1.675 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr1_-_172027269 1.637 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_-_116712644 1.598 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr13_-_85127514 1.566 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr1_-_127840290 1.531 ENSMUST00000061512.2
 Map3k19
mitogen-activated protein kinase kinase kinase 19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 9.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
1.5 7.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 3.5 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 2.8 GO:0006818 hydrogen transport(GO:0006818)
0.5 2.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.4 2.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 2.5 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.7 2.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 1.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.5 1.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 1.6 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 1.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 1.5 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.3 1.3 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 1.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 1.0 GO:0016556 mRNA modification(GO:0016556)
0.3 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.6 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
1.3 4.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4 1.6 GO:0060187 cell pole(GO:0060187)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.2 0.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.9 GO:0003774 motor activity(GO:0003774)
0.8 4.0 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.1 3.5 GO:0070888 E-box binding(GO:0070888)
0.0 3.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.4 3.1 GO:0052650 retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650)
0.0 2.8 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.6 2.5 GO:0008142 oxysterol binding(GO:0008142)
0.2 2.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.0 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.5 1.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 1.5 GO:0051015 actin filament binding(GO:0051015)
0.4 1.3 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 1.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.0 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.9 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.5 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.5 GO:0048406 nerve growth factor binding(GO:0048406)