Motif ID: Hoxd8

Z-value: 0.580


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_80165013 5.617 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr9_+_80165079 4.109 ENSMUST00000184480.1
 Myo6
myosin VI
chr2_+_83724397 3.955 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
 Itgav


integrin alpha V


chr1_-_138848576 3.654 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr3_+_127633134 3.549 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr3_+_76075583 3.451 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr6_+_34384218 3.130 ENSMUST00000038383.7
ENSMUST00000115051.1
 Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr1_+_9547948 2.830 ENSMUST00000144177.1
 Adhfe1
alcohol dehydrogenase, iron containing, 1
chr19_+_23723279 2.546 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr3_+_94372794 2.545 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr6_+_71282280 2.497 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr18_+_11633276 2.463 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr5_-_62766153 2.211 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_-_35155750 1.990 ENSMUST00000067033.7
ENSMUST00000018476.7
 Stk3

serine/threonine kinase 3

chr12_-_84617326 1.830 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr5_-_111761697 1.675 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr1_-_172027269 1.637 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_-_116712644 1.598 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr13_-_85127514 1.566 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr1_-_127840290 1.531 ENSMUST00000061512.2
 Map3k19
mitogen-activated protein kinase kinase kinase 19
chr4_+_118961578 1.481 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr5_+_92809372 1.478 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr4_-_132398199 1.340 ENSMUST00000136711.1
ENSMUST00000084249.4
 Phactr4

phosphatase and actin regulator 4

chr11_+_117809687 1.280 ENSMUST00000120928.1
ENSMUST00000175737.1
 Syngr2

synaptogyrin 2

chr8_-_84662841 1.256 ENSMUST00000060427.4
 Ier2
immediate early response 2
chr10_+_58394361 1.255 ENSMUST00000020077.4
 Lims1
LIM and senescent cell antigen-like domains 1
chr11_+_117809653 1.156 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr3_+_88716838 1.147 ENSMUST00000029692.8
ENSMUST00000171645.1
 Rit1

Ras-like without CAAX 1

chr3_+_88716884 1.069 ENSMUST00000172252.1
 Rit1
Ras-like without CAAX 1
chr12_-_90969768 1.044 ENSMUST00000181184.1
 4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr17_-_48432723 0.957 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr1_+_178798438 0.948 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr9_-_55512156 0.879 ENSMUST00000034866.8
 Etfa
electron transferring flavoprotein, alpha polypeptide
chr2_-_160619971 0.854 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr1_+_178405881 0.755 ENSMUST00000027775.7
 Efcab2
EF-hand calcium binding domain 2
chr14_+_47298260 0.689 ENSMUST00000166743.1
 Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr13_+_49608030 0.629 ENSMUST00000021822.5
 Ogn
osteoglycin
chr10_+_75037291 0.623 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr7_-_99980431 0.611 ENSMUST00000080817.4
 Rnf169
ring finger protein 169
chr9_+_54538984 0.585 ENSMUST00000060242.5
ENSMUST00000118413.1
 Sh2d7

SH2 domain containing 7

chr7_+_110772604 0.546 ENSMUST00000005829.6
 Ampd3
adenosine monophosphate deaminase 3
chr11_+_109543694 0.531 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr7_+_39588931 0.509 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr10_+_23797052 0.481 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chr7_-_80405425 0.468 ENSMUST00000107362.3
ENSMUST00000135306.1
 Furin

furin (paired basic amino acid cleaving enzyme)

chr1_-_158814469 0.465 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr5_+_48372363 0.430 ENSMUST00000030968.2
 Pacrgl
PARK2 co-regulated-like
chr17_-_56036546 0.426 ENSMUST00000003268.9
 Sh3gl1
SH3-domain GRB2-like 1
chr10_-_76110956 0.418 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr7_-_45062393 0.407 ENSMUST00000129101.1
 Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr10_-_127030813 0.367 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr5_-_38491948 0.348 ENSMUST00000129099.1
 Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chrX_-_74393003 0.338 ENSMUST00000015427.6
 Fam3a
family with sequence similarity 3, member A
chr3_-_96197580 0.328 ENSMUST00000016087.3
 Bola1
bolA-like 1 (E. coli)
chr2_-_163472561 0.317 ENSMUST00000109418.1
 Fitm2
fat storage-inducing transmembrane protein 2
chr3_+_10088173 0.296 ENSMUST00000061419.7
 Gm9833
predicted gene 9833
chr2_-_177267036 0.293 ENSMUST00000108963.1
 Gm14409
predicted gene 14409
chr12_-_87444017 0.268 ENSMUST00000091090.4
 2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr2_+_110597298 0.267 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr17_-_32822200 0.239 ENSMUST00000179695.1
 Zfp799
zinc finger protein 799
chrX_-_160138375 0.223 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr19_-_33761949 0.204 ENSMUST00000025694.6
ENSMUST00000147153.1
 Lipo1
Lipo2
lipase, member O1
lipase, member O2
chr3_-_95871367 0.188 ENSMUST00000142437.1
ENSMUST00000067298.4
 Mrps21

mitochondrial ribosomal protein S21

chr13_-_58354862 0.185 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr5_-_73191848 0.183 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr11_+_16257706 0.166 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr8_+_34054622 0.161 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr14_+_55560010 0.147 ENSMUST00000147981.1
ENSMUST00000133256.1
 Dcaf11

DDB1 and CUL4 associated factor 11

chr10_-_25200110 0.143 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr10_-_127030789 0.141 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr7_+_126976338 0.084 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr12_-_54695885 0.075 ENSMUST00000067272.8
 Eapp
E2F-associated phosphoprotein
chr8_+_40354303 0.051 ENSMUST00000136835.1
 Micu3
mitochondrial calcium uptake family, member 3
chr18_+_60774675 0.042 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr14_+_55559993 0.038 ENSMUST00000117236.1
 Dcaf11
DDB1 and CUL4 associated factor 11
chr14_+_58893465 0.038 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr17_+_74489492 0.005 ENSMUST00000024873.6
 Yipf4
Yip1 domain family, member 4
chrM_+_7759 0.005 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr8_+_33599608 0.003 ENSMUST00000009774.9
 Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.7 9.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.7 2.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.5 1.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.5 2.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.4 2.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.3 1.3 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 1.6 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.3 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 1.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.3 1.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.5 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.4 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 0.5 GO:0032264 IMP salvage(GO:0032264)
0.0 0.6 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 1.0 GO:0016556 mRNA modification(GO:0016556)
0.0 0.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.3 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 3.5 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 2.8 GO:0006818 hydrogen transport(GO:0006818)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 1.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 1.5 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 2.5 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 0.2 GO:0003351 epithelial cilium movement(GO:0003351)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.4 1.6 GO:0060187 cell pole(GO:0060187)
0.4 9.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 0.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 2.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.6 2.5 GO:0008142 oxysterol binding(GO:0008142)
0.5 1.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.4 3.1 GO:0052650 retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650)
0.4 1.3 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.2 2.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 2.0 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.1 10.9 GO:0003774 motor activity(GO:0003774)
0.1 3.5 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.5 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.5 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.9 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 1.0 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 3.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.8 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 1.5 GO:0051015 actin filament binding(GO:0051015)