Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 3.320


Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.603.0e-08Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.467.3e-05Click!
Irf2mm10_v2_chr8_+_46739745_467397910.397.9e-04Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.318.4e-03Click!
Irf7mm10_v2_chr7_-_141266415_141266481-0.244.8e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 69.046 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr9_+_3034599 66.046 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3023547 65.270 ENSMUST00000099046.3
Gm10718
predicted gene 10718
chr9_+_3027439 64.522 ENSMUST00000177875.1
ENSMUST00000179982.1
Gm10717

predicted gene 10717

chr9_+_3017408 61.688 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 61.441 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr2_-_98667264 58.929 ENSMUST00000099683.1
Gm10800
predicted gene 10800
chr9_+_3004457 58.170 ENSMUST00000178348.1
Gm11168
predicted gene 11168
chr9_+_3000922 57.405 ENSMUST00000151376.2
Gm10722
predicted gene 10722
chr14_-_19418930 56.249 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3037111 55.324 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3036877 52.570 ENSMUST00000155807.2
Gm10715
predicted gene 10715
chr9_+_3005125 52.546 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3025417 48.447 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3018753 48.272 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr2_-_105399286 44.533 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr19_+_36409719 31.293 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr2_-_51972990 28.282 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr2_+_98662227 27.813 ENSMUST00000099684.3
Gm10801
predicted gene 10801
chr6_+_57580992 27.017 ENSMUST00000031817.8
Herc6
hect domain and RLD 6

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 320 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.1 39.4 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
4.8 33.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
5.9 29.6 GO:1900122 positive regulation of receptor binding(GO:1900122)
2.4 28.5 GO:0044458 motile cilium assembly(GO:0044458)
2.6 26.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
3.2 25.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 23.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
4.2 21.2 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.3 19.9 GO:0034501 protein localization to kinetochore(GO:0034501)
1.4 19.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.8 18.8 GO:0035855 megakaryocyte development(GO:0035855)
3.6 18.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
2.8 16.9 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.3 16.2 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 15.5 GO:0008360 regulation of cell shape(GO:0008360)
2.1 15.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
3.6 14.4 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 14.4 GO:0043010 camera-type eye development(GO:0043010)
0.2 14.2 GO:0097194 execution phase of apoptosis(GO:0097194)
1.7 13.7 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 136.9 GO:0005575 cellular_component(GO:0005575)
4.1 53.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 33.1 GO:0031519 PcG protein complex(GO:0031519)
0.1 32.7 GO:0005667 transcription factor complex(GO:0005667)
0.3 32.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 27.6 GO:0036126 sperm flagellum(GO:0036126)
1.7 26.6 GO:0005614 interstitial matrix(GO:0005614)
2.8 25.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 23.0 GO:0005925 focal adhesion(GO:0005925)
0.0 21.4 GO:0005654 nucleoplasm(GO:0005654)
0.4 19.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 19.1 GO:0005604 basement membrane(GO:0005604)
2.1 18.6 GO:0030478 actin cap(GO:0030478)
1.2 17.8 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.6 15.2 GO:0030914 STAGA complex(GO:0030914)
1.3 14.5 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
4.8 14.4 GO:0070557 PCNA-p21 complex(GO:0070557)
3.1 12.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 12.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.9 11.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 57.7 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 33.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 30.4 GO:0030332 cyclin binding(GO:0030332)
5.3 26.6 GO:0032027 myosin light chain binding(GO:0032027)
1.1 25.4 GO:0045295 gamma-catenin binding(GO:0045295)
1.7 24.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
5.3 21.2 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 18.8 GO:0004386 helicase activity(GO:0004386)
0.0 18.1 GO:0005525 GTP binding(GO:0005525)
4.5 17.9 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
4.2 16.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
4.9 14.6 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.6 14.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.9 13.7 GO:0017166 vinculin binding(GO:0017166)
0.3 12.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 12.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.7 11.9 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 11.8 GO:0033613 activating transcription factor binding(GO:0033613)
2.9 11.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.6 11.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)