Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7
Z-value: 3.320





Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Irf1 | ENSMUSG00000018899.10 | Irf1 |
Irf2 | ENSMUSG00000031627.7 | Irf2 |
Irf7 | ENSMUSG00000025498.8 | Irf7 |
Irf8 | ENSMUSG00000041515.3 | Irf8 |
Irf9 | ENSMUSG00000002325.8 | Irf9 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Irf1 | mm10_v2_chr11_+_53770458_53770509 | 0.60 | 3.0e-08 | Click! |
Irf8 | mm10_v2_chr8_+_120736352_120736385 | 0.46 | 7.3e-05 | Click! |
Irf2 | mm10_v2_chr8_+_46739745_46739791 | 0.39 | 7.9e-04 | Click! |
Irf9 | mm10_v2_chr14_+_55604550_55604579 | -0.31 | 8.4e-03 | Click! |
Irf7 | mm10_v2_chr7_-_141266415_141266481 | -0.24 | 4.8e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 320 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
13.1 | 39.4 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
4.8 | 33.6 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
5.9 | 29.6 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
2.4 | 28.5 | GO:0044458 | motile cilium assembly(GO:0044458) |
2.6 | 26.2 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
3.2 | 25.4 | GO:0048625 | myoblast fate commitment(GO:0048625) |
0.2 | 23.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
4.2 | 21.2 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
1.3 | 19.9 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
1.4 | 19.8 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
0.8 | 18.8 | GO:0035855 | megakaryocyte development(GO:0035855) |
3.6 | 18.1 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
2.8 | 16.9 | GO:0010528 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) |
0.3 | 16.2 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
0.1 | 15.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
2.1 | 15.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
3.6 | 14.4 | GO:1902990 | mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
0.1 | 14.4 | GO:0043010 | camera-type eye development(GO:0043010) |
0.2 | 14.2 | GO:0097194 | execution phase of apoptosis(GO:0097194) |
1.7 | 13.7 | GO:1900225 | NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 145 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 136.9 | GO:0005575 | cellular_component(GO:0005575) |
4.1 | 53.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.5 | 33.1 | GO:0031519 | PcG protein complex(GO:0031519) |
0.1 | 32.7 | GO:0005667 | transcription factor complex(GO:0005667) |
0.3 | 32.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.4 | 27.6 | GO:0036126 | sperm flagellum(GO:0036126) |
1.7 | 26.6 | GO:0005614 | interstitial matrix(GO:0005614) |
2.8 | 25.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.1 | 23.0 | GO:0005925 | focal adhesion(GO:0005925) |
0.0 | 21.4 | GO:0005654 | nucleoplasm(GO:0005654) |
0.4 | 19.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.2 | 19.1 | GO:0005604 | basement membrane(GO:0005604) |
2.1 | 18.6 | GO:0030478 | actin cap(GO:0030478) |
1.2 | 17.8 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.6 | 15.2 | GO:0030914 | STAGA complex(GO:0030914) |
1.3 | 14.5 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
4.8 | 14.4 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
3.1 | 12.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
0.2 | 12.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
1.9 | 11.6 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 217 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 57.7 | GO:0043774 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) |
0.1 | 33.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.7 | 30.4 | GO:0030332 | cyclin binding(GO:0030332) |
5.3 | 26.6 | GO:0032027 | myosin light chain binding(GO:0032027) |
1.1 | 25.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
1.7 | 24.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
5.3 | 21.2 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
0.1 | 18.8 | GO:0004386 | helicase activity(GO:0004386) |
0.0 | 18.1 | GO:0005525 | GTP binding(GO:0005525) |
4.5 | 17.9 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
4.2 | 16.9 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
4.9 | 14.6 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
0.6 | 14.6 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.9 | 13.7 | GO:0017166 | vinculin binding(GO:0017166) |
0.3 | 12.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.5 | 12.2 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.7 | 11.9 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
0.2 | 11.8 | GO:0033613 | activating transcription factor binding(GO:0033613) |
2.9 | 11.6 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.6 | 11.3 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |