Motif ID: Irf3

Z-value: 0.710


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.253.4e-02Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 62 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_36409719 4.710 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr18_-_32559914 4.249 ENSMUST00000174000.1
ENSMUST00000174459.1
Gypc

glycophorin C

chr2_-_105399286 3.993 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr15_+_32920723 3.413 ENSMUST00000022871.5
Sdc2
syndecan 2
chr3_+_81932601 3.231 ENSMUST00000029649.2
Ctso
cathepsin O
chr6_-_39118211 3.154 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr7_-_104315455 2.955 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr13_+_74639866 2.852 ENSMUST00000169114.1
Erap1
endoplasmic reticulum aminopeptidase 1
chr2_+_122147680 2.844 ENSMUST00000102476.4
B2m
beta-2 microglobulin
chr8_-_71537402 2.756 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr17_+_75178797 2.651 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr16_+_35938470 2.548 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr3_+_142560108 2.481 ENSMUST00000128609.1
ENSMUST00000029935.7
Gbp3

guanylate binding protein 3

chr3_+_142560052 2.451 ENSMUST00000106222.2
Gbp3
guanylate binding protein 3
chr17_+_75178911 2.449 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr3_+_142530329 2.393 ENSMUST00000171263.1
ENSMUST00000045097.9
Gbp7

guanylate binding protein 7

chr10_-_87493651 2.389 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr16_+_35938972 2.339 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr14_-_65833963 2.202 ENSMUST00000022613.9
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr2_-_51934644 2.124 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.9 6.0 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 5.1 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
1.0 4.9 GO:1900122 positive regulation of receptor binding(GO:1900122)
1.1 4.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 3.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.2 2.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.7 2.6 GO:0009597 detection of virus(GO:0009597)
0.8 2.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.4 2.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 2.0 GO:0006457 protein folding(GO:0006457)
0.4 1.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.3 1.7 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2 1.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 1.2 GO:0016082 synaptic vesicle priming(GO:0016082)
0.4 1.1 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 1.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.1 GO:0055070 copper ion homeostasis(GO:0055070)
0.2 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
1.7 5.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 4.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 4.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 4.2 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 2.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.8 GO:0005770 late endosome(GO:0005770)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 2.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 2.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.6 1.7 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.0 1.2 GO:0030914 STAGA complex(GO:0030914)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 1.0 GO:1990462 omegasome(GO:1990462)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 6.8 GO:0003924 GTPase activity(GO:0003924)
1.3 5.1 GO:0050436 microfibril binding(GO:0050436)
0.1 4.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 3.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.1 GO:0005525 GTP binding(GO:0005525)
0.4 2.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 2.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.8 GO:0001948 glycoprotein binding(GO:0001948)
0.1 2.4 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.6 2.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 2.1 GO:0039706 co-receptor binding(GO:0039706)
0.4 1.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 1.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 1.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)