Motif ID: Irf3

Z-value: 0.710


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.253.4e-02Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_36409719 4.710 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr18_-_32559914 4.249 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr2_-_105399286 3.993 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr15_+_32920723 3.413 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr3_+_81932601 3.231 ENSMUST00000029649.2
 Ctso
cathepsin O
chr6_-_39118211 3.154 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr7_-_104315455 2.955 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr13_+_74639866 2.852 ENSMUST00000169114.1
 Erap1
endoplasmic reticulum aminopeptidase 1
chr2_+_122147680 2.844 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr8_-_71537402 2.756 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr17_+_75178797 2.651 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr16_+_35938470 2.548 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr3_+_142560108 2.481 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr3_+_142560052 2.451 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr17_+_75178911 2.449 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr3_+_142530329 2.393 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr10_-_87493651 2.389 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr16_+_35938972 2.339 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr14_-_65833963 2.202 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr2_-_51934644 2.124 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr13_-_23710714 2.079 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr7_-_100514800 2.033 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr3_+_142560351 1.948 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr11_-_48871408 1.923 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr1_+_61638819 1.776 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr7_-_102565425 1.760 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr4_-_40239779 1.501 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_51934943 1.405 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr5_-_137116177 1.400 ENSMUST00000054384.5
ENSMUST00000152207.1
 Trim56

tripartite motif-containing 56

chr7_-_116198487 1.323 ENSMUST00000181981.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr6_-_23839137 1.197 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr14_+_14012491 1.183 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr16_-_10785525 1.155 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr11_-_48871344 1.153 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr6_-_34317442 1.145 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr4_-_40239700 1.130 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_119393060 1.107 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr19_+_43752996 1.064 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr2_-_173276144 1.033 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr7_-_104353328 1.020 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr5_+_114896936 1.015 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr15_+_79892397 0.954 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr11_+_109362771 0.838 ENSMUST00000020930.7
ENSMUST00000106702.3
 Gna13

guanine nucleotide binding protein, alpha 13

chrX_+_68678712 0.762 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr15_+_79892436 0.752 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr2_+_152962485 0.680 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chrX_+_68678541 0.650 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr9_-_35176039 0.630 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr11_+_58199556 0.622 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr2_-_62646146 0.515 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr6_-_54972603 0.512 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr16_-_35939082 0.382 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chrX_+_68678624 0.334 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr10_+_83543941 0.315 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene
chr10_-_81496329 0.283 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr10_-_81496313 0.263 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr7_-_45136231 0.237 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chrX_+_101429555 0.169 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr11_+_72301613 0.056 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr16_-_35871544 0.050 ENSMUST00000042665.8
 Parp14
poly (ADP-ribose) polymerase family, member 14
chr15_-_39112642 0.048 ENSMUST00000022908.8
 Slc25a32
solute carrier family 25, member 32
chr9_+_108508005 0.005 ENSMUST00000006838.8
ENSMUST00000134939.1
 Qars

glutaminyl-tRNA synthetase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.0 4.9 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.9 6.0 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.8 2.4 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.7 2.6 GO:0009597 detection of virus(GO:0009597)
0.6 9.3 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.4 2.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.4 1.1 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.4 1.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.3 1.7 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.2 2.7 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 1.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 5.1 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 0.5 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.2 1.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.5 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.1 0.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 0.2 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 0.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.6 GO:0042832 defense response to protozoan(GO:0042832)
0.1 1.1 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 1.2 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 3.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)
0.0 2.0 GO:0006457 protein folding(GO:0006457)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.8 9.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.6 0.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.6 1.7 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.5 4.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 2.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 1.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.2 1.0 GO:1990462 omegasome(GO:1990462)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.1 4.7 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.2 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.8 GO:0005770 late endosome(GO:0005770)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0050436 microfibril binding(GO:0050436)
0.6 2.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 1.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.4 8.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 2.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 1.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 0.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.2 2.1 GO:0039706 co-receptor binding(GO:0039706)
0.2 2.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.3 GO:0070097 delta-catenin binding(GO:0070097)
0.1 4.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.4 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 3.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 6.8 GO:0003924 GTPase activity(GO:0003924)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 3.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.8 GO:0001948 glycoprotein binding(GO:0001948)
0.0 3.1 GO:0005525 GTP binding(GO:0005525)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)