Motif ID: Irf4

Z-value: 0.615


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_163313661 7.539 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr3_+_90537242 6.141 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr3_+_90537306 6.107 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr11_-_77894096 5.506 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr6_-_87335758 4.807 ENSMUST00000042025.9
 Antxr1
anthrax toxin receptor 1
chr9_+_85842852 4.147 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr13_-_113046357 3.836 ENSMUST00000022282.3
 Gpx8
glutathione peroxidase 8 (putative)
chr3_-_142395661 3.729 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
 Pdlim5



PDZ and LIM domain 5



chr19_-_24225015 3.713 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chr14_+_60732906 3.308 ENSMUST00000162945.1
 Spata13
spermatogenesis associated 13
chr2_-_127788854 2.965 ENSMUST00000028857.7
ENSMUST00000110357.1
 Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chrX_-_134161928 2.938 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr1_+_61638819 2.934 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr10_+_128706251 2.928 ENSMUST00000054125.8
 Pmel
premelanosome protein
chr6_+_71282280 2.925 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr13_-_81570640 2.857 ENSMUST00000109565.2
 Gpr98
G protein-coupled receptor 98
chr6_+_128362919 2.843 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr6_+_82041623 2.793 ENSMUST00000042974.8
 Eva1a
eva-1 homolog A (C. elegans)
chr11_+_119393060 2.725 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr7_+_58658181 2.662 ENSMUST00000168747.1
 Atp10a
ATPase, class V, type 10A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.2 GO:0051592 response to calcium ion(GO:0051592)
0.1 7.9 GO:0051963 regulation of synapse assembly(GO:0051963)
0.6 7.5 GO:0048664 neuron fate determination(GO:0048664)
1.8 5.5 GO:0006553 lysine metabolic process(GO:0006553)
1.6 4.8 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.9 3.7 GO:1903011 negative regulation of bone development(GO:1903011)
0.4 3.3 GO:0033504 floor plate development(GO:0033504)
0.1 3.3 GO:0046847 filopodium assembly(GO:0046847)
0.4 3.0 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.3 3.0 GO:0042447 hormone catabolic process(GO:0042447)
0.4 2.9 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 2.9 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.4 2.8 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 2.8 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.3 2.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 2.7 GO:0015914 phospholipid transport(GO:0015914)
0.9 2.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.4 2.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.8 2.4 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.1 2.4 GO:0031670 cellular response to nutrient(GO:0031670)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.5 GO:0005730 nucleolus(GO:0005730)
0.0 5.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 4.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 3.7 GO:0005921 gap junction(GO:0005921)
0.0 3.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.3 GO:0030175 filopodium(GO:0030175)
0.1 3.0 GO:0097546 ciliary base(GO:0097546)
0.0 3.0 GO:0005811 lipid particle(GO:0005811)
0.6 2.9 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 2.8 GO:0032993 protein-DNA complex(GO:0032993)
0.3 2.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.3 2.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 2.2 GO:0005901 caveola(GO:0005901)
0.5 2.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.3 1.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 1.5 GO:0042825 TAP complex(GO:0042825)
0.3 1.3 GO:1990357 terminal web(GO:1990357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.2 GO:0005509 calcium ion binding(GO:0005509)
0.2 6.7 GO:0071837 HMG box domain binding(GO:0071837)
1.4 5.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 5.5 GO:0005178 integrin binding(GO:0005178)
0.1 3.9 GO:0005518 collagen binding(GO:0005518)
0.2 3.8 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.7 GO:0042805 actinin binding(GO:0042805)
0.0 3.7 GO:0030674 protein binding, bridging(GO:0030674)
0.4 3.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 2.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 2.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 2.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.4 2.4 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.3 2.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 2.2 GO:0003684 damaged DNA binding(GO:0003684)
0.2 2.0 GO:0044548 S100 protein binding(GO:0044548)
0.0 2.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)