Motif ID: Irf5_Irf6

Z-value: 0.633

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6






Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_142395661 7.229 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chr7_-_141010759 6.882 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr2_-_69586021 5.410 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr11_+_88999376 5.170 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr19_+_55741810 4.568 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr1_-_163313661 4.409 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr7_+_128523576 4.184 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr17_+_23679363 3.674 ENSMUST00000024699.2
Cldn6
claudin 6
chr16_+_35938972 3.139 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr6_-_39118211 3.053 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr4_-_40239779 2.944 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_+_45042425 2.721 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr17_-_6782775 2.315 ENSMUST00000064234.6
Ezr
ezrin
chr15_+_9436028 1.819 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr4_-_40239700 1.806 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_14381242 1.702 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr5_+_92809372 1.646 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr16_-_5255923 1.604 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr11_-_86201144 1.548 ENSMUST00000044423.3
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr16_+_35938470 1.454 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr4_-_136886187 1.398 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chrX_+_77511002 1.390 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr6_+_57580992 1.357 ENSMUST00000031817.8
Herc6
hect domain and RLD 6
chr11_+_69966896 1.282 ENSMUST00000151515.1
Cldn7
claudin 7
chr2_-_51934644 1.165 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr7_-_65370908 1.112 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr2_-_77170592 1.039 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr17_-_78882508 0.955 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr5_+_99979061 0.931 ENSMUST00000046721.1
4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr12_-_73113407 0.901 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chr17_+_34203527 0.872 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_60699758 0.866 ENSMUST00000108719.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chrM_+_8600 0.836 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr9_-_123851855 0.781 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1

FYVE and coiled-coil domain containing 1

chr16_-_91646906 0.699 ENSMUST00000120450.1
ENSMUST00000023684.7
Gart

phosphoribosylglycinamide formyltransferase

chr11_+_60699718 0.675 ENSMUST00000052346.3
Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr9_+_57072024 0.658 ENSMUST00000169879.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr2_-_77519565 0.631 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr8_-_105568298 0.548 ENSMUST00000005849.5
Agrp
agouti related protein
chr12_-_31950170 0.544 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr5_-_99978914 0.508 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr6_-_13608011 0.503 ENSMUST00000031554.2
Tmem168
transmembrane protein 168
chr16_-_35939082 0.498 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr15_+_96287518 0.470 ENSMUST00000134985.2
ENSMUST00000096250.4
Arid2

AT rich interactive domain 2 (ARID, RFX-like)

chr6_-_87838671 0.469 ENSMUST00000089497.4
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr11_+_101582236 0.465 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
Tmem106a



transmembrane protein 106A



chrM_+_9452 0.465 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr12_-_31950210 0.383 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr16_-_67620805 0.336 ENSMUST00000120594.1
Cadm2
cell adhesion molecule 2
chr9_+_55326913 0.250 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr12_+_26469204 0.236 ENSMUST00000020969.3
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr3_+_135438722 0.232 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr1_+_52119438 0.228 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr7_+_83755904 0.211 ENSMUST00000051522.8
ENSMUST00000042280.7
Gm7964

predicted gene 7964

chr15_+_99126513 0.173 ENSMUST00000063517.4
Spats2
spermatogenesis associated, serine-rich 2
chr7_-_126396715 0.138 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr1_-_184732616 0.085 ENSMUST00000048572.6
Hlx
H2.0-like homeobox
chr17_+_34644805 0.045 ENSMUST00000174796.1
Fkbpl
FK506 binding protein-like
chr16_-_67620880 0.038 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2

cell adhesion molecule 2

chr4_+_108460000 0.003 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0009597 detection of virus(GO:0009597)
0.8 2.3 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.7 4.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.6 12.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.6 4.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.5 5.4 GO:0045056 transcytosis(GO:0045056)
0.3 4.4 GO:0048664 neuron fate determination(GO:0048664)
0.3 0.9 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) skeletal muscle fiber differentiation(GO:0098528)
0.2 0.7 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 0.9 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.2 7.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 0.5 GO:0045472 response to ether(GO:0045472)
0.2 1.0 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.2 0.8 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 0.5 GO:0000389 generation of catalytic spliceosome for second transesterification step(GO:0000350) mRNA 3'-splice site recognition(GO:0000389)
0.2 4.2 GO:0071260 negative regulation of striated muscle cell apoptotic process(GO:0010664) cellular response to mechanical stimulus(GO:0071260)
0.2 1.5 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
0.1 0.7 GO:0046654 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 1.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.2 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.1 0.2 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 1.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 1.0 GO:0051642 centrosome localization(GO:0051642)
0.0 1.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.1 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 1.7 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 1.4 GO:0043627 response to estrogen(GO:0043627)
0.0 0.5 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 3.7 GO:0045216 cell-cell junction organization(GO:0045216)
0.0 0.8 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.5 GO:0010390 histone monoubiquitination(GO:0010390)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0097454 Schwann cell microvillus(GO:0097454)
0.5 4.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 6.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.9 GO:0042825 TAP complex(GO:0042825)
0.1 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 11.4 GO:0030018 Z disc(GO:0030018)
0.1 5.4 GO:0031526 brush border membrane(GO:0031526)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 4.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.4 GO:0005876 spindle microtubule(GO:0005876)
0.0 7.9 GO:0045177 apical part of cell(GO:0045177)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.4 GO:0030492 hemoglobin binding(GO:0030492)
0.7 4.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 5.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 7.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 7.2 GO:0042805 actinin binding(GO:0042805)
0.2 0.7 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637)
0.2 0.9 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.2 4.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 2.3 GO:0044548 S100 protein binding(GO:0044548)
0.1 4.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.2 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.1 5.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0030332 cyclin binding(GO:0030332)
0.0 1.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.7 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.1 GO:0031386 protein tag(GO:0031386)