Motif ID: Irx6_Irx2_Irx3

Z-value: 0.740

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72628831_72628971-0.334.9e-03Click!
Irx3mm10_v2_chr8_-_91801948_918020670.208.9e-02Click!
Irx6mm10_v2_chr8_+_92674289_926742890.181.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 13.235 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr16_+_17146937 5.491 ENSMUST00000115706.1
ENSMUST00000069064.4
Ydjc

YdjC homolog (bacterial)

chr10_-_125328957 4.915 ENSMUST00000063318.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr9_-_112232449 4.231 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr2_-_119271202 2.800 ENSMUST00000037360.7
Rhov
ras homolog gene family, member V
chr7_+_19212521 2.776 ENSMUST00000060225.4
Gpr4
G protein-coupled receptor 4
chr8_+_36489191 2.554 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr13_+_76579670 2.505 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr10_+_26229707 2.453 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr13_+_16014457 2.416 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr10_-_29699379 2.411 ENSMUST00000092620.4
Gm10275
predicted pseudogene 10275
chr18_+_35770318 2.284 ENSMUST00000165299.1
Gm16490
predicted gene 16490
chr7_+_140763739 2.181 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr7_-_60005101 2.114 ENSMUST00000059305.10
Snrpn
small nuclear ribonucleoprotein N
chr6_-_48708206 2.081 ENSMUST00000119315.1
ENSMUST00000053661.4
Gimap6

GTPase, IMAP family member 6

chr6_-_56901870 1.957 ENSMUST00000101367.2
Nt5c3
5'-nucleotidase, cytosolic III
chr10_+_61171954 1.936 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
Tbata


thymus, brain and testes associated


chr8_+_84872105 1.629 ENSMUST00000136026.1
ENSMUST00000170296.1
Syce2

synaptonemal complex central element protein 2

chr1_-_22315792 1.608 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chr7_-_103843154 1.578 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 13.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 5.0 GO:0034605 cellular response to heat(GO:0034605)
1.2 4.9 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.9 2.8 GO:0072008 glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0 2.5 GO:0008033 tRNA processing(GO:0008033)
0.5 2.4 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 2.2 GO:0048515 spermatid differentiation(GO:0048515)
0.1 2.1 GO:0017144 drug metabolic process(GO:0017144)
0.2 2.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 2.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 2.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.3 1.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 1.6 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 1.6 GO:0015671 oxygen transport(GO:0015671)
0.1 1.6 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 1.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.5 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.1 1.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 1.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 1.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 13.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 2.8 GO:0005833 hemoglobin complex(GO:0005833)
0.2 2.6 GO:0005687 U4 snRNP(GO:0005687)
0.8 2.4 GO:0043512 inhibin A complex(GO:0043512)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.0 2.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.7 GO:0030496 midbody(GO:0030496)
0.5 1.6 GO:0000801 central element(GO:0000801)
0.0 1.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.5 GO:0031672 A band(GO:0031672)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.1 GO:0005787 signal peptidase complex(GO:0005787)
0.2 1.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.0 GO:0046930 pore complex(GO:0046930)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 5.5 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
1.2 4.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 3.9 GO:0005525 GTP binding(GO:0005525)
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.9 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.7 2.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.4 2.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.2 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.0 2.1 GO:0005516 calmodulin binding(GO:0005516)
0.3 2.0 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 2.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 1.5 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.1 GO:0043022 ribosome binding(GO:0043022)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 1.0 GO:0072541 peroxynitrite reductase activity(GO:0072541)