Motif ID: Isl1

Z-value: 0.337


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_1163096990.132.8e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 3.511 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_+_45017953 1.925 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr15_-_50889691 1.576 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr5_-_37824580 1.551 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr7_-_25250720 1.505 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr9_+_37367354 1.466 ENSMUST00000051839.7
Hepacam
hepatocyte cell adhesion molecule
chr10_-_13388753 1.311 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr14_-_118052235 1.279 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr1_+_12718496 1.273 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr19_+_55741810 1.038 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_-_137766474 1.029 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr3_-_49757257 1.010 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr9_+_35423582 0.974 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr15_+_62037986 0.891 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr4_-_14621805 0.876 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr4_-_82850721 0.843 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr8_-_105568298 0.805 ENSMUST00000005849.5
Agrp
agouti related protein
chr6_-_24956106 0.792 ENSMUST00000127247.2
Tmem229a
transmembrane protein 229A
chrX_+_99975570 0.772 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr19_+_55742242 0.760 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.5 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.4 3.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 2.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.3 1.9 GO:0019532 oxalate transport(GO:0019532)
0.3 1.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 1.9 GO:0060325 face morphogenesis(GO:0060325)
0.5 1.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.3 1.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.3 1.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.3 0.8 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 0.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.8 GO:0032196 transposition(GO:0032196)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 0.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 0.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.2 0.7 GO:0006597 spermine biosynthetic process(GO:0006597)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0005667 transcription factor complex(GO:0005667)
0.3 3.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:1990357 terminal web(GO:1990357)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.0 0.5 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 2.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 1.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.3 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 0.7 GO:0019808 polyamine binding(GO:0019808)
0.1 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)