Motif ID: Isl1

Z-value: 0.337


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_1163096990.132.8e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_154960915 3.511 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr7_+_45017953 1.925 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr15_-_50889691 1.576 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr5_-_37824580 1.551 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr7_-_25250720 1.505 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr9_+_37367354 1.466 ENSMUST00000051839.7
Hepacam
hepatocyte cell adhesion molecule
chr10_-_13388753 1.311 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr14_-_118052235 1.279 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr1_+_12718496 1.273 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr19_+_55741810 1.038 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_-_137766474 1.029 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr3_-_49757257 1.010 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr9_+_35423582 0.974 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr15_+_62037986 0.891 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr4_-_14621805 0.876 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr4_-_82850721 0.843 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr8_-_105568298 0.805 ENSMUST00000005849.5
Agrp
agouti related protein
chr6_-_24956106 0.792 ENSMUST00000127247.2
Tmem229a
transmembrane protein 229A
chrX_+_99975570 0.772 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr19_+_55742242 0.760 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr14_+_124005355 0.757 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr15_-_93519499 0.739 ENSMUST00000109255.2
Prickle1
prickle homolog 1 (Drosophila)
chr12_-_73047179 0.728 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr10_-_35711891 0.724 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chrX_+_96455359 0.684 ENSMUST00000033553.7
Heph
hephaestin
chr3_-_104818539 0.661 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chr8_-_61902669 0.633 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr6_-_144209558 0.627 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr6_-_144209471 0.624 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr6_-_144209448 0.600 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr2_-_127788854 0.594 ENSMUST00000028857.7
ENSMUST00000110357.1
Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chrX_+_56779437 0.585 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr19_+_55741884 0.577 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr19_+_55742056 0.576 ENSMUST00000111659.2
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr15_-_50882806 0.570 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr4_-_14621669 0.565 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr9_-_95815389 0.555 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr6_+_30568367 0.541 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr2_+_120476911 0.522 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr10_+_88091070 0.516 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr14_-_12345847 0.473 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr4_-_14621494 0.445 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_-_42661893 0.424 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr3_-_150073620 0.416 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr10_-_128176568 0.406 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_+_109917639 0.402 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr4_-_42168603 0.392 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr15_-_50890396 0.389 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr19_+_3986564 0.382 ENSMUST00000054030.7
Acy3
aspartoacylase (aminoacylase) 3
chr2_-_72986716 0.373 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr17_+_71204647 0.358 ENSMUST00000126681.1
Lpin2
lipin 2
chr10_+_26772477 0.349 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chrX_+_106920618 0.332 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr1_+_74542881 0.331 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
Plcd4




phospholipase C, delta 4




chr3_-_25212720 0.326 ENSMUST00000091289.3
Gm10259
predicted pseudogene 10259
chr15_+_44196135 0.303 ENSMUST00000038856.6
ENSMUST00000110289.3
Trhr

thyrotropin releasing hormone receptor

chr4_+_154964117 0.301 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr1_-_183147461 0.299 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chr6_-_13871477 0.290 ENSMUST00000139231.1
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr1_+_146420434 0.280 ENSMUST00000163646.1
Gm5263
predicted gene 5263
chr4_+_3940747 0.270 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr9_-_37147257 0.261 ENSMUST00000039674.5
ENSMUST00000080754.5
Pknox2

Pbx/knotted 1 homeobox 2

chr10_-_93081596 0.254 ENSMUST00000168617.1
ENSMUST00000168110.1
ENSMUST00000020200.7
Gm872


RIKEN cDNA 4930485B16 gene


chr2_+_153161303 0.237 ENSMUST00000089027.2
Tm9sf4
transmembrane 9 superfamily protein member 4
chr4_+_94739276 0.234 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr16_-_91069142 0.232 ENSMUST00000035689.1
ENSMUST00000114076.1
4932438H23Rik

RIKEN cDNA 4932438H23 gene

chr12_-_12941827 0.219 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr17_-_78684262 0.214 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr13_-_103764502 0.207 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr3_-_95754841 0.203 ENSMUST00000029752.8
ENSMUST00000074339.6
ENSMUST00000163530.1
ENSMUST00000098857.4
Tars2



threonyl-tRNA synthetase 2, mitochondrial (putative)



chr3_-_57294880 0.203 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr16_-_22161450 0.189 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chrX_+_153237466 0.184 ENSMUST00000143880.1
Klf8
Kruppel-like factor 8
chr18_+_6332587 0.183 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr11_+_74649462 0.182 ENSMUST00000092915.5
ENSMUST00000117818.1
Cluh

clustered mitochondria (cluA/CLU1) homolog

chr13_+_63014934 0.181 ENSMUST00000091560.4
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr9_+_94669876 0.175 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr9_-_112187898 0.175 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr7_-_118116171 0.158 ENSMUST00000131374.1
Rps15a
ribosomal protein S15A
chr7_-_118116128 0.158 ENSMUST00000128482.1
ENSMUST00000131840.1
Rps15a

ribosomal protein S15A

chr2_-_71367749 0.157 ENSMUST00000151937.1
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr2_+_158794807 0.156 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr17_-_46680870 0.147 ENSMUST00000165007.1
ENSMUST00000071841.5
Klhdc3

kelch domain containing 3

chr17_+_46681038 0.141 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr17_-_24533709 0.138 ENSMUST00000061764.7
Rab26
RAB26, member RAS oncogene family
chr13_+_63282142 0.124 ENSMUST00000159152.1
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr7_+_119760918 0.118 ENSMUST00000106527.1
ENSMUST00000106528.1
ENSMUST00000063770.3
ENSMUST00000106529.1
Acsm3



acyl-CoA synthetase medium-chain family member 3



chr19_+_24875679 0.118 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr14_-_62761112 0.114 ENSMUST00000053959.6
Ints6
integrator complex subunit 6
chr9_+_53771499 0.113 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr8_-_71511762 0.093 ENSMUST00000048452.4
Plvap
plasmalemma vesicle associated protein
chr2_-_169405435 0.086 ENSMUST00000131509.1
4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr1_+_164503306 0.084 ENSMUST00000181831.1
Gm26685
predicted gene, 26685
chrX_-_153037549 0.084 ENSMUST00000051484.3
Mageh1
melanoma antigen, family H, 1
chr3_+_88553716 0.076 ENSMUST00000008748.6
Ubqln4
ubiquilin 4
chr4_-_42084291 0.076 ENSMUST00000177937.1
Gm21968
predicted gene, 21968
chr13_+_56702983 0.074 ENSMUST00000069557.7
ENSMUST00000109876.1
Smad5

SMAD family member 5

chr2_+_121456963 0.069 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr4_+_41903610 0.064 ENSMUST00000098128.3
Gm21541
predicted gene, 21541
chr18_-_47333311 0.064 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr4_-_120951664 0.056 ENSMUST00000106280.1
Zfp69
zinc finger protein 69
chr13_+_56703504 0.055 ENSMUST00000109874.1
Smad5
SMAD family member 5
chr1_-_10038106 0.053 ENSMUST00000027050.3
Cops5
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
chr7_+_140763739 0.042 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_-_107875035 0.028 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.5 1.6 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.4 3.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 1.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.3 1.9 GO:0019532 oxalate transport(GO:0019532)
0.3 1.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.3 0.8 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.2 0.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 0.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.2 0.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 1.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 0.6 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.2 0.5 GO:2001015 G1 to G0 transition involved in cell differentiation(GO:0070315) negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 0.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.8 GO:0032196 transposition(GO:0032196)
0.1 2.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.6 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.2 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.1 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 1.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 1.0 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.7 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.7 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.3 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.3 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.6 GO:1990357 terminal web(GO:1990357)
0.1 1.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 1.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.5 GO:0030315 T-tubule(GO:0030315)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.0 6.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.7 GO:0019808 polyamine binding(GO:0019808)
0.2 1.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 3.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0019002 GMP binding(GO:0019002)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 5.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0015197 peptide transporter activity(GO:0015197)
0.0 2.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.0 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)