Motif ID: Isl2

Z-value: 0.697


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 172 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53771499 3.849 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr10_-_77166545 3.462 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr12_-_10900296 3.202 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr1_+_12718496 3.126 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr9_+_72806874 2.763 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr17_+_17402672 2.674 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr16_-_76403673 2.321 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chrX_-_60893430 2.167 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr17_-_48432723 2.099 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chrX_+_96455359 2.061 ENSMUST00000033553.7
Heph
hephaestin
chr14_+_27039001 1.949 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr9_-_100506844 1.928 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr9_+_108560422 1.924 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr12_+_109546409 1.893 ENSMUST00000143847.1
Meg3
maternally expressed 3
chr4_+_3940747 1.864 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr7_+_100159241 1.844 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr6_-_136941887 1.836 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr17_+_12119274 1.735 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chrX_+_136245065 1.702 ENSMUST00000048687.4
Wbp5
WW domain binding protein 5
chr3_-_33082004 1.647 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.8 3.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 2.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 2.7 GO:0097352 autophagosome maturation(GO:0097352)
0.9 2.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.3 2.2 GO:0019532 oxalate transport(GO:0019532)
0.1 2.2 GO:0007530 sex determination(GO:0007530)
0.0 2.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.1 GO:0080111 DNA demethylation(GO:0080111)
0.1 2.1 GO:0006825 copper ion transport(GO:0006825)
0.5 1.9 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.3 1.9 GO:0006177 GMP biosynthetic process(GO:0006177)
0.6 1.8 GO:0009106 lipoate metabolic process(GO:0009106)
0.4 1.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.0 1.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.2 1.6 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 1.6 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 1.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.5 1.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.5 GO:0005581 collagen trimer(GO:0005581)
0.0 2.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4 1.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.5 GO:0002102 podosome(GO:0002102)
0.2 1.4 GO:0001740 Barr body(GO:0001740)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0030673 axolemma(GO:0030673)
0.2 1.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.1 GO:0061617 MICOS complex(GO:0061617)
0.1 1.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.0 GO:0036156 inner dynein arm(GO:0036156)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0005198 structural molecule activity(GO:0005198)
0.6 3.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.9 2.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.2 2.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 2.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 2.0 GO:0003777 microtubule motor activity(GO:0003777)
0.6 1.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 1.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 1.9 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 1.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.8 GO:0016415 octanoyltransferase activity(GO:0016415)
0.1 1.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 1.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 1.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.5 GO:0050699 WW domain binding(GO:0050699)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)