Motif ID: Klf1

Z-value: 2.413


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.599.5e-08Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_44310213 27.554 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr7_-_46179929 27.145 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr5_-_139325616 25.386 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr6_+_5725639 24.723 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr10_-_81025521 24.510 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr11_+_104231390 23.982 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr11_+_104231515 22.568 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr15_+_83791939 22.140 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr11_+_104231465 21.403 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr12_-_4841583 20.340 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr10_-_81472859 19.831 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr6_+_103510874 19.805 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr8_+_84723003 18.895 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr10_+_127078886 18.881 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_+_106470281 17.826 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_+_62575981 17.704 ENSMUST00000102643.1
 Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr2_-_162661075 17.339 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr11_+_120721452 17.153 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr8_+_93810832 17.119 ENSMUST00000034198.8
ENSMUST00000125716.1
 Gnao1

guanine nucleotide binding protein, alpha O

chr7_-_103813913 16.981 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 535 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 105.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.8 55.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 49.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
3.2 45.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.7 34.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.8 33.4 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
1.5 32.3 GO:0016082 synaptic vesicle priming(GO:0016082)
9.2 27.6 GO:0046959 habituation(GO:0046959)
1.2 27.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.4 25.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.9 25.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
2.7 24.5 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.7 22.5 GO:0036465 synaptic vesicle recycling(GO:0036465)
1.6 21.7 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.6 21.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.7 21.1 GO:0016578 histone deubiquitination(GO:0016578)
0.7 21.1 GO:0009268 response to pH(GO:0009268)
1.5 20.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
6.8 20.5 GO:0032513 negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.9 20.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 207 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 113.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
7.5 74.9 GO:0045298 tubulin complex(GO:0045298)
0.4 74.0 GO:0045211 postsynaptic membrane(GO:0045211)
1.5 63.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 51.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.5 49.6 GO:0008021 synaptic vesicle(GO:0008021)
0.9 42.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.5 41.8 GO:0005905 clathrin-coated pit(GO:0005905)
1.9 33.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 31.8 GO:0031225 anchored component of membrane(GO:0031225)
1.2 30.9 GO:0071565 nBAF complex(GO:0071565)
0.6 29.8 GO:0031941 filamentous actin(GO:0031941)
0.2 29.5 GO:0005802 trans-Golgi network(GO:0005802)
6.7 26.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.9 25.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
3.6 25.3 GO:0044326 dendritic spine neck(GO:0044326)
0.5 25.0 GO:0005871 kinesin complex(GO:0005871)
0.8 24.5 GO:0035371 microtubule plus-end(GO:0035371)
1.3 24.2 GO:0034704 calcium channel complex(GO:0034704)
0.6 23.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 353 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 98.8 GO:0005096 GTPase activator activity(GO:0005096)
3.4 77.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.4 75.9 GO:0003924 GTPase activity(GO:0003924)
1.6 45.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
10.0 40.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 39.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
2.0 36.4 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.6 33.0 GO:0005262 calcium channel activity(GO:0005262)
2.9 32.4 GO:0038191 neuropilin binding(GO:0038191)
2.2 30.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.6 28.7 GO:0050811 GABA receptor binding(GO:0050811)
1.3 27.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.7 27.4 GO:0005267 potassium channel activity(GO:0005267)
1.7 27.3 GO:0031005 filamin binding(GO:0031005)
6.7 26.6 GO:0031720 haptoglobin binding(GO:0031720)
1.0 26.5 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.5 26.1 GO:0030276 clathrin binding(GO:0030276)
0.4 24.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.4 24.8 GO:0017075 syntaxin-1 binding(GO:0017075)
4.7 23.7 GO:0045503 dynein light chain binding(GO:0045503)