Motif ID: Klf12_Klf14_Sp4

Z-value: 0.952

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf12mm10_v2_chr14_-_100149764_1001497640.371.5e-03Click!
Sp4mm10_v2_chr12_-_118301429_1183014580.301.3e-02Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_99252839 7.781 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr9_+_80165079 5.978 ENSMUST00000184480.1
 Myo6
myosin VI
chr9_+_80165013 5.965 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr15_-_58076456 5.702 ENSMUST00000070143.6
ENSMUST00000110168.1
 Zhx1

zinc fingers and homeoboxes 1

chr13_+_92611119 4.290 ENSMUST00000049488.7
 Serinc5
serine incorporator 5
chr2_+_172345565 4.254 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr13_-_49215978 3.460 ENSMUST00000048946.6
 1110007C09Rik
RIKEN cDNA 1110007C09 gene
chr5_+_134986191 3.365 ENSMUST00000094245.2
 Cldn3
claudin 3
chr10_-_59951753 3.337 ENSMUST00000020308.3
 Ddit4
DNA-damage-inducible transcript 4
chr4_-_22488296 2.974 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr17_-_56462143 2.973 ENSMUST00000086828.3
 Ptprs
protein tyrosine phosphatase, receptor type, S
chr15_+_32244801 2.781 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr9_-_21918089 2.764 ENSMUST00000128442.1
ENSMUST00000119055.1
ENSMUST00000122211.1
ENSMUST00000115351.3
 Rab3d



RAB3D, member RAS oncogene family



chr6_+_29396665 2.670 ENSMUST00000096084.5
 Ccdc136
coiled-coil domain containing 136
chr9_-_53706211 2.664 ENSMUST00000068449.3
 Rab39
RAB39, member RAS oncogene family
chr5_-_109558957 2.594 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr10_-_127534540 2.579 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr18_+_64340225 2.544 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr2_-_134644079 2.439 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr6_+_29396576 2.425 ENSMUST00000115275.1
 Ccdc136
coiled-coil domain containing 136

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 562 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 7.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
1.8 5.3 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 4.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
1.0 4.1 GO:0009597 detection of virus(GO:0009597)
1.3 3.9 GO:0006601 creatine biosynthetic process(GO:0006601)
0.8 3.9 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
1.3 3.8 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)
0.2 3.8 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.5 3.7 GO:1902669 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of axon guidance(GO:1902669)
0.7 3.6 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.3 3.3 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.3 3.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 3.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 3.0 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 2.8 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 2.8 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 2.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.4 2.6 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.3 2.6 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 8.9 GO:0001726 ruffle(GO:0001726)
0.1 5.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 5.8 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.1 5.1 GO:0031901 early endosome membrane(GO:0031901)
0.2 4.6 GO:0031231 intrinsic component of peroxisomal membrane(GO:0031231)
0.4 4.4 GO:0044327 dendritic spine head(GO:0044327)
0.1 3.7 GO:0005776 autophagosome(GO:0005776)
0.1 3.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.7 3.0 GO:0045098 type III intermediate filament(GO:0045098)
0.0 3.0 GO:0036064 ciliary basal body(GO:0036064)
0.3 2.9 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 2.9 GO:0030426 growth cone(GO:0030426)
0.1 2.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 2.6 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 2.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.4 GO:0005605 basal lamina(GO:0005605)
0.3 2.0 GO:0070695 FHF complex(GO:0070695)
0.1 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.9 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 354 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.5 GO:0051015 actin filament binding(GO:0051015)
0.1 13.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 9.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 7.1 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 4.8 GO:0005125 cytokine activity(GO:0005125)
0.4 3.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 3.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 3.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 3.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.3 GO:0071837 HMG box domain binding(GO:0071837)
0.1 3.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 3.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 2.9 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.9 2.8 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.9 2.8 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 2.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 2.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.8 2.4 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.4 2.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 2.4 GO:0030742 GTP-dependent protein binding(GO:0030742)