Motif ID: Klf16_Sp8

Z-value: 1.315

Transcription factors associated with Klf16_Sp8:

Gene SymbolEntrez IDGene Name
Klf16 ENSMUSG00000035397.8 Klf16
Sp8 ENSMUSG00000048562.6 Sp8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp8mm10_v2_chr12_+_118846329_1188463290.811.5e-17Click!
Klf16mm10_v2_chr10_-_80577285_80577327-0.572.6e-07Click!


Activity profile for motif Klf16_Sp8.

activity profile for motif Klf16_Sp8


Sorted Z-values histogram for motif Klf16_Sp8

Sorted Z-values for motif Klf16_Sp8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf16_Sp8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25622525 29.609 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr17_-_32166879 21.407 ENSMUST00000087723.3
 Notch3
notch 3
chr7_-_38107490 21.200 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr19_+_6084983 18.988 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr7_+_45216671 18.799 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr18_+_82914632 17.470 ENSMUST00000071233.6
 Zfp516
zinc finger protein 516
chr5_+_108694222 17.126 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr17_-_70851189 16.988 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_+_117849223 16.056 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr19_+_53142756 15.687 ENSMUST00000050096.7
 Add3
adducin 3 (gamma)
chr11_+_78322965 15.613 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr11_+_62077018 15.395 ENSMUST00000092415.5
 Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr18_+_49979427 15.359 ENSMUST00000148989.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr18_+_49979514 15.279 ENSMUST00000179937.1
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr3_+_34649987 14.755 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr12_+_103314944 14.755 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr5_+_33721724 14.716 ENSMUST00000067150.7
ENSMUST00000169212.2
ENSMUST00000114411.2
ENSMUST00000164207.3
 Fgfr3



fibroblast growth factor receptor 3



chr17_-_25797032 14.601 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr9_-_21798502 14.512 ENSMUST00000034717.5
 Kank2
KN motif and ankyrin repeat domains 2
chr17_-_8148097 14.347 ENSMUST00000097420.5
 Rnaset2a
ribonuclease T2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,174 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 58.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
8.1 56.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.1 41.1 GO:0038092 nodal signaling pathway(GO:0038092)
1.5 39.8 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
1.5 35.6 GO:0006270 DNA replication initiation(GO:0006270)
2.4 34.2 GO:0030903 notochord development(GO:0030903)
0.7 33.8 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
2.4 33.0 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
2.7 32.3 GO:0044458 motile cilium assembly(GO:0044458)
1.0 29.8 GO:0050873 brown fat cell differentiation(GO:0050873)
5.9 29.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
4.9 29.5 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
1.1 28.2 GO:0034508 centromere complex assembly(GO:0034508)
5.5 27.5 GO:0007386 compartment pattern specification(GO:0007386)
0.9 27.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
5.3 26.3 GO:0061314 Notch signaling involved in heart development(GO:0061314)
1.0 25.9 GO:0051310 metaphase plate congression(GO:0051310)
1.6 25.7 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.2 24.4 GO:0046325 negative regulation of glucose import(GO:0046325)
0.4 24.4 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 378 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 273.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 174.8 GO:0005615 extracellular space(GO:0005615)
0.3 91.3 GO:0005925 focal adhesion(GO:0005925)
1.6 78.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 59.3 GO:0005654 nucleoplasm(GO:0005654)
0.8 50.9 GO:0005844 polysome(GO:0005844)
0.8 48.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 46.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.9 45.2 GO:0000791 euchromatin(GO:0000791)
0.6 37.5 GO:0005902 microvillus(GO:0005902)
0.2 37.1 GO:0000790 nuclear chromatin(GO:0000790)
0.8 35.7 GO:0005876 spindle microtubule(GO:0005876)
0.4 33.9 GO:0030175 filopodium(GO:0030175)
4.7 32.8 GO:0000796 condensin complex(GO:0000796)
0.4 32.7 GO:0044291 cell-cell contact zone(GO:0044291)
0.2 30.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 29.4 GO:0005814 centriole(GO:0005814)
2.5 27.9 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.5 27.8 GO:0005581 collagen trimer(GO:0005581)
8.7 26.1 GO:0031021 interphase microtubule organizing center(GO:0031021)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 631 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 193.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.4 57.8 GO:0051015 actin filament binding(GO:0051015)
1.4 56.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.8 40.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 39.8 GO:0001047 core promoter binding(GO:0001047)
0.7 38.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
4.2 37.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 37.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.7 36.4 GO:0070410 co-SMAD binding(GO:0070410)
0.3 35.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 33.8 GO:0042393 histone binding(GO:0042393)
0.9 32.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.9 32.2 GO:0017166 vinculin binding(GO:0017166)
0.1 32.1 GO:0003677 DNA binding(GO:0003677)
1.2 31.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.9 31.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.1 29.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.5 28.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
5.6 28.1 GO:0032027 myosin light chain binding(GO:0032027)
1.1 27.3 GO:0071837 HMG box domain binding(GO:0071837)