Motif ID: Klf4_Sp3

Z-value: 1.594

Transcription factors associated with Klf4_Sp3:

Gene SymbolEntrez IDGene Name
Klf4 ENSMUSG00000003032.8 Klf4
Sp3 ENSMUSG00000027109.10 Sp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp3mm10_v2_chr2_-_72980402_72980471-0.671.6e-10Click!
Klf4mm10_v2_chr4_-_55532453_55532485-0.272.2e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Klf4_Sp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_29289300 20.089 ENSMUST00000048187.4
Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr8_+_87473116 19.558 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
Gm2694


predicted gene 2694


chr8_+_105518736 16.445 ENSMUST00000034363.5
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr7_-_143460989 16.403 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_117133953 15.373 ENSMUST00000076859.5
Plk3
polo-like kinase 3
chr6_-_72958097 14.414 ENSMUST00000114049.1
Tmsb10
thymosin, beta 10
chr12_+_17690793 14.010 ENSMUST00000071858.3
Hpcal1
hippocalcin-like 1
chr8_-_87472365 13.807 ENSMUST00000169693.1
Cbln1
cerebellin 1 precursor protein
chr10_-_127534540 13.516 ENSMUST00000095266.2
Nxph4
neurexophilin 4
chr8_-_87472576 12.821 ENSMUST00000034076.8
Cbln1
cerebellin 1 precursor protein
chr13_+_54789377 12.402 ENSMUST00000026993.7
ENSMUST00000131692.2
ENSMUST00000163796.1
Tspan17


tetraspanin 17


chr6_-_72958465 11.990 ENSMUST00000114050.1
Tmsb10
thymosin, beta 10
chr13_+_54789500 11.499 ENSMUST00000163915.1
ENSMUST00000099503.3
ENSMUST00000171859.1
Tspan17


tetraspanin 17


chr4_-_129239165 11.165 ENSMUST00000097873.3
C77080
expressed sequence C77080
chrX_+_73639414 10.933 ENSMUST00000019701.8
Dusp9
dual specificity phosphatase 9
chr7_-_34812677 10.390 ENSMUST00000078686.6
Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr6_-_115994953 10.224 ENSMUST00000015511.8
Plxnd1
plexin D1
chr7_+_45163915 10.197 ENSMUST00000085374.5
Slc17a7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr11_+_32276893 9.991 ENSMUST00000145569.1
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr19_+_53529100 9.966 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,167 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 26.7 GO:0015671 oxygen transport(GO:0015671)
1.9 26.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.9 24.9 GO:0016578 histone deubiquitination(GO:0016578)
0.3 24.3 GO:0006364 rRNA processing(GO:0006364)
2.2 23.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
1.7 23.1 GO:0051764 actin crosslink formation(GO:0051764)
0.6 20.6 GO:0006101 citrate metabolic process(GO:0006101)
3.4 20.2 GO:0006177 GMP biosynthetic process(GO:0006177)
1.2 20.0 GO:0060065 uterus development(GO:0060065)
2.5 19.8 GO:0008343 adult feeding behavior(GO:0008343)
1.9 19.4 GO:0008354 germ cell migration(GO:0008354)
0.8 19.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
3.8 18.9 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
1.2 18.6 GO:0038092 nodal signaling pathway(GO:0038092)
1.5 18.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.6 18.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.1 18.0 GO:0050832 defense response to fungus(GO:0050832)
1.4 17.4 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.6 17.0 GO:0006783 heme biosynthetic process(GO:0006783)
0.8 16.9 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 423 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 100.5 GO:0005829 cytosol(GO:0005829)
0.4 40.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.5 37.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 35.6 GO:0005730 nucleolus(GO:0005730)
0.8 34.5 GO:0008180 COP9 signalosome(GO:0008180)
0.5 33.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.6 32.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 32.3 GO:0005874 microtubule(GO:0005874)
1.3 31.5 GO:0071565 nBAF complex(GO:0071565)
3.4 26.9 GO:0005833 hemoglobin complex(GO:0005833)
0.6 26.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 26.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 22.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.8 20.1 GO:0002102 podosome(GO:0002102)
0.9 18.6 GO:0030914 STAGA complex(GO:0030914)
1.1 17.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.5 17.8 GO:0030057 desmosome(GO:0030057)
0.3 17.5 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.3 16.5 GO:0005643 nuclear pore(GO:0005643)
2.7 16.1 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 633 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 118.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 44.1 GO:0002039 p53 binding(GO:0002039)
0.9 41.5 GO:0061650 ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.9 34.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.5 33.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 31.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
1.0 29.4 GO:0003785 actin monomer binding(GO:0003785)
0.9 28.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
5.6 27.8 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
5.3 26.7 GO:0005344 oxygen transporter activity(GO:0005344)
2.7 24.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 23.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
1.1 23.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.4 23.8 GO:0003743 translation initiation factor activity(GO:0003743)
1.0 23.5 GO:0031489 myosin V binding(GO:0031489)
1.4 23.2 GO:0031005 filamin binding(GO:0031005)
1.6 22.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.3 21.9 GO:0008565 protein transporter activity(GO:0008565)
1.5 21.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.8 21.0 GO:0004027 alcohol sulfotransferase activity(GO:0004027)