Motif ID: Klf7

Z-value: 0.527


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121456_641214910.291.4e-02Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 3.528 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr2_-_156312470 3.406 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr6_-_88875035 2.883 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr12_-_4592927 2.546 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr5_+_137778849 2.303 ENSMUST00000126126.1
ENSMUST00000031739.4
 Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr1_-_138847579 2.123 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr5_-_137741601 2.014 ENSMUST00000119498.1
ENSMUST00000061789.7
 Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr6_-_88874597 1.980 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
 Podxl2


podocalyxin-like 2


chr3_+_28263205 1.769 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr4_+_107830958 1.385 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr2_+_119047116 1.319 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr12_+_49382791 1.281 ENSMUST00000179669.1
 Foxg1
forkhead box G1
chr9_-_32344237 1.186 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr12_+_49383007 1.137 ENSMUST00000021333.3
 Foxg1
forkhead box G1
chr6_+_52714219 1.090 ENSMUST00000138040.1
ENSMUST00000129660.1
 Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr2_+_119047129 1.066 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr15_-_102722150 1.009 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chr3_+_106721893 0.977 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
 Lrif1



ligand dependent nuclear receptor interacting factor 1



chr1_-_23383149 0.952 ENSMUST00000027343.5
 Ogfrl1
opioid growth factor receptor-like 1
chr15_-_102722120 0.916 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1
chr5_+_137761680 0.902 ENSMUST00000110983.2
ENSMUST00000031738.4
 Tsc22d4

TSC22 domain family, member 4

chr7_-_28766469 0.879 ENSMUST00000085851.5
ENSMUST00000032815.4
 Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr2_-_151973387 0.875 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr2_+_32775769 0.860 ENSMUST00000066352.5
 Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr3_+_106721672 0.818 ENSMUST00000098750.2
ENSMUST00000130105.1
 Lrif1

ligand dependent nuclear receptor interacting factor 1

chr2_+_172550991 0.810 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr7_-_74013676 0.760 ENSMUST00000026896.4
 St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_+_52713729 0.673 ENSMUST00000080723.4
ENSMUST00000149588.1
 Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr6_+_125039760 0.658 ENSMUST00000140131.1
ENSMUST00000032480.7
 Ing4

inhibitor of growth family, member 4

chr11_-_61494173 0.640 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr2_+_156312589 0.556 ENSMUST00000073942.5
ENSMUST00000109580.1
 Cnbd2

cyclic nucleotide binding domain containing 2

chr17_+_24488773 0.532 ENSMUST00000024958.7
 Caskin1
CASK interacting protein 1
chr4_-_87230435 0.526 ENSMUST00000107157.2
 Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr2_-_73892619 0.525 ENSMUST00000112007.1
ENSMUST00000112016.2
 Atf2

activating transcription factor 2

chr2_-_130424242 0.464 ENSMUST00000089581.4
 Pced1a
PC-esterase domain containing 1A
chr15_+_99074968 0.445 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr5_-_115348953 0.435 ENSMUST00000040154.8
 Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr15_+_30172570 0.407 ENSMUST00000081728.5
 Ctnnd2
catenin (cadherin associated protein), delta 2
chr2_-_73892588 0.403 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
 Atf2


activating transcription factor 2


chr11_+_78536355 0.394 ENSMUST00000128788.1
 Ift20
intraflagellar transport 20
chr11_-_101302206 0.348 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
 Becn1



beclin 1, autophagy related



chr13_+_21722057 0.348 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr7_+_28766747 0.341 ENSMUST00000170068.1
ENSMUST00000072965.4
 Sirt2

sirtuin 2

chr4_+_152178126 0.337 ENSMUST00000075363.3
 Acot7
acyl-CoA thioesterase 7
chr7_-_68749170 0.330 ENSMUST00000118110.1
ENSMUST00000048068.7
 Arrdc4

arrestin domain containing 4

chr5_-_34187670 0.324 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr8_+_3500451 0.322 ENSMUST00000004683.6
ENSMUST00000160338.1
 Mcoln1

mucolipin 1

chr8_+_71367210 0.314 ENSMUST00000019169.7
 Use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr2_-_156180135 0.305 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr11_-_40733373 0.296 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr12_-_11436607 0.295 ENSMUST00000072299.5
 Vsnl1
visinin-like 1
chr7_+_45154297 0.283 ENSMUST00000107813.1
ENSMUST00000125953.1
ENSMUST00000085375.5
ENSMUST00000144597.1
 Pih1d1



PIH1 domain containing 1



chr4_-_132329414 0.278 ENSMUST00000127402.1
ENSMUST00000105962.3
ENSMUST00000030730.7
ENSMUST00000105960.1
 Trnau1ap



tRNA selenocysteine 1 associated protein 1



chr7_-_141414115 0.277 ENSMUST00000106008.1
 Pddc1
Parkinson disease 7 domain containing 1
chr11_+_78536393 0.270 ENSMUST00000050366.8
ENSMUST00000108275.1
 Ift20

intraflagellar transport 20

chr15_-_98953541 0.270 ENSMUST00000097014.5
 Tuba1a
tubulin, alpha 1A
chr15_-_89196457 0.267 ENSMUST00000078953.7
 Dennd6b
DENN/MADD domain containing 6B
chr4_+_139622842 0.261 ENSMUST00000039818.9
 Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr5_-_124187150 0.259 ENSMUST00000161938.1
 Pitpnm2
phosphatidylinositol transfer protein, membrane-associated 2
chr7_+_80261202 0.256 ENSMUST00000117989.1
 Ngrn
neugrin, neurite outgrowth associated
chr18_+_67133713 0.249 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr7_+_45154644 0.244 ENSMUST00000153973.1
 Pih1d1
PIH1 domain containing 1
chr8_-_22476809 0.240 ENSMUST00000163774.1
ENSMUST00000033935.8
 Smim19

small integral membrane protein 19

chr10_+_86705811 0.230 ENSMUST00000061458.7
ENSMUST00000075632.6
 BC030307

cDNA sequence BC030307

chr2_-_73892530 0.221 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
 Atf2



activating transcription factor 2



chr7_+_126976338 0.218 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr10_-_86705485 0.209 ENSMUST00000020238.7
 Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr8_+_3621529 0.204 ENSMUST00000156380.2
 Pet100
PET100 homolog (S. cerevisiae)
chr7_-_45154519 0.187 ENSMUST00000007977.7
ENSMUST00000107815.1
 Aldh16a1

aldehyde dehydrogenase 16 family, member A1

chr5_+_45520221 0.186 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
 Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr1_+_171329015 0.184 ENSMUST00000111300.1
 Dedd
death effector domain-containing
chr7_-_132776855 0.182 ENSMUST00000106168.1
 Fam53b
family with sequence similarity 53, member B
chr11_+_72301613 0.177 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr2_+_158375638 0.153 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr5_+_140607334 0.150 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_-_120120937 0.142 ENSMUST00000151708.1
 Dbi
diazepam binding inhibitor
chr1_+_57406328 0.142 ENSMUST00000027114.5
 9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr8_+_71922810 0.122 ENSMUST00000119003.1
 Zfp617
zinc finger protein 617
chr1_+_163929765 0.121 ENSMUST00000027876.4
ENSMUST00000170359.1
 Scyl3

SCY1-like 3 (S. cerevisiae)

chr1_-_120121030 0.116 ENSMUST00000027634.6
 Dbi
diazepam binding inhibitor
chr2_-_130424673 0.091 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr4_+_127126034 0.090 ENSMUST00000094712.4
 Gm12942
predicted gene 12942
chr1_-_172082757 0.081 ENSMUST00000003550.4
 Ncstn
nicastrin
chr13_+_96542727 0.069 ENSMUST00000077672.4
ENSMUST00000109444.2
 Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr12_+_118846329 0.067 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr19_+_5637475 0.056 ENSMUST00000025867.5
 Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr5_+_33658123 0.056 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chrX_+_136270253 0.040 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr1_-_57406443 0.034 ENSMUST00000160837.1
ENSMUST00000161780.1
 Tyw5

tRNA-yW synthesizing protein 5

chr8_+_70152754 0.032 ENSMUST00000072500.6
ENSMUST00000164040.1
ENSMUST00000110146.2
ENSMUST00000110143.1
ENSMUST00000110141.2
ENSMUST00000110140.1
 2310045N01Rik

Mef2b



RIKEN cDNA 2310045N01 gene

myocyte enhancer factor 2B



chr3_+_51224447 0.025 ENSMUST00000023849.8
ENSMUST00000167780.1
 Ccrn4l

CCR4 carbon catabolite repression 4-like (S. cerevisiae)

chr1_+_172082796 0.015 ENSMUST00000027833.5
 Copa
coatomer protein complex subunit alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0021852 pyramidal neuron migration(GO:0021852)
0.7 3.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.4 2.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 1.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4 1.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 4.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.3 0.8 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 0.6 GO:0070375 ERK5 cascade(GO:0070375)
0.2 0.7 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 2.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 1.4 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 0.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.5 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.1 0.7 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.3 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.7 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.2 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.3 GO:0006537 glutamate biosynthetic process(GO:0006537) proline biosynthetic process(GO:0006561)
0.0 2.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.2 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.0 0.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 2.0 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 1.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.1 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.9 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.9 GO:0006970 response to osmotic stress(GO:0006970)
0.0 1.5 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 0.0 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.3 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.5 GO:0060292 long term synaptic depression(GO:0060292)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.1 0.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.3 GO:0033010 paranodal junction(GO:0033010)
0.1 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.9 GO:0055037 recycling endosome(GO:0055037)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0030315 T-tubule(GO:0030315)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.3 1.4 GO:0038025 reelin receptor activity(GO:0038025)
0.2 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 0.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.8 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.3 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.2 GO:0050827 toxin receptor binding(GO:0050827)
0.1 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0019172 glyoxalase III activity(GO:0019172)
0.1 1.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.3 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0019145 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0 0.5 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 1.8 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0097001 sphingolipid transporter activity(GO:0046624) ceramide binding(GO:0097001)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)