Motif ID: Klf8

Z-value: 1.121


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.671.6e-10Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 25.158 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr6_-_72788952 17.122 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr9_-_8004585 13.350 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr7_-_144939823 11.576 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr14_-_103843685 11.012 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr4_+_46450892 10.987 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr18_-_74961252 10.508 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr13_-_60177357 10.318 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr2_-_36105271 9.575 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
 Lhx6


LIM homeobox protein 6


chr1_-_20820213 9.156 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr7_+_4119556 8.892 ENSMUST00000079415.5
 Ttyh1
tweety homolog 1 (Drosophila)
chr7_+_4119525 8.878 ENSMUST00000119661.1
ENSMUST00000129423.1
 Ttyh1

tweety homolog 1 (Drosophila)

chr7_-_127026479 8.846 ENSMUST00000032916.4
 Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_+_172550991 8.503 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr11_-_109473220 7.636 ENSMUST00000070872.6
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr11_-_32222233 7.396 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr1_+_172499948 7.246 ENSMUST00000111230.1
 Tagln2
transgelin 2
chrX_+_96096034 6.994 ENSMUST00000117399.1
 Msn
moesin
chr18_-_78206408 6.863 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr13_+_48261427 6.532 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 29.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 17.8 GO:1902476 chloride transmembrane transport(GO:1902476)
5.7 17.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
2.6 15.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
2.2 13.4 GO:0060242 contact inhibition(GO:0060242)
1.7 11.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.3 11.2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
3.7 11.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.7 10.9 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
3.5 10.5 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
3.4 10.3 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
1.0 10.3 GO:0042473 outer ear morphogenesis(GO:0042473)
0.3 9.7 GO:0009299 mRNA transcription(GO:0009299)
1.6 9.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 9.2 GO:0006270 DNA replication initiation(GO:0006270)
1.8 8.8 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
2.8 8.5 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.8 8.5 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.1 8.1 GO:0050709 negative regulation of protein secretion(GO:0050709)
1.8 7.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 21.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
5.9 17.8 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
4.9 14.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.4 12.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 11.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.6 9.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 9.2 GO:0042555 MCM complex(GO:0042555)
0.8 7.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.1 5.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 5.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 5.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 5.3 GO:0000139 Golgi membrane(GO:0000139)
1.0 5.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 4.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 4.9 GO:0005903 brush border(GO:0005903)
0.3 4.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
1.5 4.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.5 4.4 GO:0005588 collagen type V trimer(GO:0005588)
0.0 4.4 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
1.3 29.7 GO:0070410 co-SMAD binding(GO:0070410)
1.0 23.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 18.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
4.4 17.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 11.6 GO:0017080 sodium channel regulator activity(GO:0017080)
3.7 11.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.7 10.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
2.6 10.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.3 9.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 9.7 GO:0003678 DNA helicase activity(GO:0003678)
0.1 8.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 7.3 GO:0030165 PDZ domain binding(GO:0030165)
1.1 6.9 GO:0015265 urea channel activity(GO:0015265)
0.1 6.9 GO:0001948 glycoprotein binding(GO:0001948)
2.1 6.4 GO:0017089 glycolipid transporter activity(GO:0017089)
0.4 6.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
2.1 6.2 GO:0005534 galactose binding(GO:0005534)
1.9 5.8 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
1.0 5.8 GO:0019841 retinol binding(GO:0019841)