Motif ID: Lef1

Z-value: 1.630


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.458.5e-05Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_70474923 22.809 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr3_-_57575760 20.696 ENSMUST00000029380.7
Wwtr1
WW domain containing transcription regulator 1
chr2_+_73271925 19.785 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr3_-_57575907 18.733 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr14_-_98169542 17.543 ENSMUST00000069334.7
ENSMUST00000071533.6
Dach1

dachshund 1 (Drosophila)

chr7_-_115824699 16.704 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr19_-_59170978 15.338 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr8_-_46294592 14.310 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr12_-_119238794 13.610 ENSMUST00000026360.8
Itgb8
integrin beta 8
chr2_-_26092149 13.299 ENSMUST00000114159.2
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr5_+_75075464 13.090 ENSMUST00000160104.1
ENSMUST00000040477.3
Gsx2

GS homeobox 2

chr2_+_71528657 12.680 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr17_-_70851189 12.660 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr7_-_37772868 11.241 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr18_-_62756275 9.914 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr19_+_55742242 9.823 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr7_-_116038734 9.265 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr7_+_45216671 9.121 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr15_-_8710734 9.109 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_144939823 8.422 ENSMUST00000093962.4
Ccnd1
cyclin D1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 39.4 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
2.3 36.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.6 28.4 GO:0048625 myoblast fate commitment(GO:0048625)
2.4 26.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.0 24.1 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.8 17.6 GO:0001967 suckling behavior(GO:0001967)
5.8 17.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
4.3 17.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
4.2 16.7 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 13.9 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
1.3 13.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
1.1 13.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.1 12.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
4.2 12.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.7 11.9 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.7 11.6 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.4 11.3 GO:0009409 response to cold(GO:0009409)
3.6 10.8 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1 10.8 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.4 10.5 GO:0001573 ganglioside metabolic process(GO:0001573)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 134.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 90.7 GO:0005634 nucleus(GO:0005634)
3.2 28.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 17.5 GO:0005730 nucleolus(GO:0005730)
1.0 17.3 GO:0043205 fibril(GO:0043205)
0.3 17.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 14.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.6 13.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.5 13.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.0 10.2 GO:0008623 CHRAC(GO:0008623)
0.1 9.5 GO:0072686 mitotic spindle(GO:0072686)
2.8 8.4 GO:0042585 germinal vesicle(GO:0042585)
0.5 7.5 GO:0005614 interstitial matrix(GO:0005614)
1.2 7.4 GO:0000235 astral microtubule(GO:0000235)
1.8 7.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 7.2 GO:0005871 kinesin complex(GO:0005871)
0.5 5.8 GO:0031105 septin complex(GO:0031105)
0.3 5.6 GO:0016580 Sin3 complex(GO:0016580)
0.9 5.2 GO:0044294 dendritic growth cone(GO:0044294)
2.5 5.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 115.8 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.1 56.9 GO:0003677 DNA binding(GO:0003677)
1.8 50.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 31.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 23.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 19.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
1.2 18.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
5.8 17.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
3.5 17.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
1.9 15.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.5 13.9 GO:0008432 JUN kinase binding(GO:0008432)
0.3 13.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.5 12.8 GO:0001968 fibronectin binding(GO:0001968)
0.7 11.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 8.9 GO:0004697 protein kinase C activity(GO:0004697)
0.8 8.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.3 8.1 GO:0070064 proline-rich region binding(GO:0070064)
0.6 7.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 7.9 GO:0051015 actin filament binding(GO:0051015)
0.6 7.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)