Motif ID: Lhx3

Z-value: 0.674


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_45103747 5.903 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr4_+_136143497 5.872 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_-_103827922 4.465 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr4_-_14621805 3.898 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_+_49608030 3.777 ENSMUST00000021822.5
 Ogn
osteoglycin
chr17_-_67950908 3.644 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr3_+_122419772 3.052 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr4_+_102589687 2.899 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr13_-_101692624 2.327 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr3_+_151437887 2.273 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr10_-_64090265 2.271 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr11_+_109543694 2.245 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr5_-_70842617 2.172 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_-_84425258 2.168 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr2_-_33087169 2.124 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_33086366 2.047 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr4_-_14621669 1.884 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr2_+_125136692 1.849 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr4_-_14621494 1.845 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr14_+_80000292 1.781 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_+_34780412 1.767 ENSMUST00000115016.1
ENSMUST00000115017.1
 Agbl3

ATP/GTP binding protein-like 3

chrX_-_139871637 1.712 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr8_-_21906412 1.642 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr10_-_33624587 1.631 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr10_-_64090241 1.593 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr1_-_38821215 1.556 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr2_-_164171113 1.497 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr6_+_96115249 1.494 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr14_+_69347587 1.389 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr10_-_53647080 1.328 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr11_-_30198232 1.290 ENSMUST00000102838.3
 Sptbn1
spectrin beta, non-erythrocytic 1
chr5_+_66968961 1.277 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr3_+_84952146 1.270 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chr11_+_59306920 1.262 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr19_+_26623419 1.166 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_62765618 1.125 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_-_62507737 1.088 ENSMUST00000020271.6
 Srgn
serglycin
chr3_-_57294880 1.074 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chr1_-_158356258 1.063 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr14_-_48665098 1.048 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr3_+_66985680 1.005 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr6_+_124304646 1.001 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr18_+_57468478 0.999 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr5_-_62766153 0.899 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_75037291 0.855 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr12_-_56536895 0.830 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr5_-_51553896 0.806 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr15_+_16778101 0.769 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr3_+_66985647 0.764 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr18_+_37477768 0.762 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr19_+_20601958 0.734 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chrX_+_66653003 0.732 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr3_-_67515487 0.656 ENSMUST00000178314.1
ENSMUST00000054825.4
 Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr10_+_102158858 0.650 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr2_+_36230426 0.628 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_+_118961578 0.604 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr10_+_116143881 0.580 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr10_-_35711891 0.546 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr1_+_177444653 0.537 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr5_-_118244861 0.529 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr3_+_142620596 0.521 ENSMUST00000165774.1
 Gbp2
guanylate binding protein 2
chr13_+_93304799 0.505 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr10_+_36506814 0.454 ENSMUST00000167191.1
ENSMUST00000058738.4
 Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr3_-_116712644 0.407 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr4_-_147809788 0.395 ENSMUST00000105734.3
ENSMUST00000176201.1
 Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr3_+_136670076 0.367 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chrX_+_166344692 0.350 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr17_-_78684262 0.344 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr7_-_45830776 0.336 ENSMUST00000107723.2
ENSMUST00000131384.1
 Grwd1

glutamate-rich WD repeat containing 1

chr13_+_93304066 0.246 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr2_+_3114220 0.230 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr9_+_113812547 0.224 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chrM_+_9452 0.220 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_+_75037066 0.199 ENSMUST00000147802.1
ENSMUST00000020391.5
 Rab36

RAB36, member RAS oncogene family

chr4_+_147132038 0.164 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr7_+_100159241 0.151 ENSMUST00000032967.3
 Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr4_+_147492417 0.116 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr3_+_53845086 0.071 ENSMUST00000108014.1
 Gm10985
predicted gene 10985
chr4_+_146610961 0.055 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr6_+_37870786 0.054 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chr1_-_36273425 0.046 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr10_-_37138863 0.031 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chrX_-_94123087 0.028 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr3_+_95318782 0.022 ENSMUST00000139866.1
 Cers2
ceramide synthase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.6 GO:0019532 oxalate transport(GO:0019532)
0.9 3.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.5 2.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.5 1.4 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.4 1.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.3 1.3 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.3 1.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.3 0.8 GO:0021759 globus pallidus development(GO:0021759)
0.3 0.8 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.3 1.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 3.9 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 2.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 2.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 5.9 GO:0071398 cellular response to fatty acid(GO:0071398)
0.2 0.6 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 0.5 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 1.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.4 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.4 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 2.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 2.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.5 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 5.7 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 1.0 GO:0006953 acute-phase response(GO:0006953)
0.1 1.8 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 1.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.5 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.6 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 1.6 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 1.3 GO:0032437 cuticular plate(GO:0032437)
0.3 1.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.1 GO:0042629 mast cell granule(GO:0042629)
0.1 1.8 GO:0042581 specific granule(GO:0042581)
0.1 2.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.5 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 1.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 6.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 5.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 3.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 4.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.0 GO:0042585 germinal vesicle(GO:0042585)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0019770 IgG receptor activity(GO:0019770)
1.1 4.5 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.7 7.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.6 2.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.5 2.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.3 2.2 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.3 1.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 0.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 1.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.5 GO:0019808 polyamine binding(GO:0019808)
0.1 0.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.7 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.2 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 4.6 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.8 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 2.9 GO:0030552 cAMP binding(GO:0030552)
0.1 0.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.4 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.3 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.8 GO:0008083 growth factor activity(GO:0008083)
0.0 3.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 1.3 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)
0.0 3.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)