Motif ID: Lhx8
Z-value: 0.522
Transcription factors associated with Lhx8:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Lhx8 | ENSMUSG00000096225.2 | Lhx8 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Lhx8 | mm10_v2_chr3_-_154330543_154330576 | -0.31 | 9.3e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.7 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
0.6 | 1.8 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
0.5 | 1.5 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.5 | 6.4 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
0.4 | 1.1 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
0.3 | 1.6 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
0.3 | 2.4 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
0.2 | 1.2 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.2 | 0.6 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
0.2 | 2.0 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.1 | 1.5 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
0.1 | 0.5 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
0.1 | 1.8 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
0.1 | 0.5 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.1 | 0.2 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
0.0 | 1.0 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.0 | 0.6 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
0.0 | 1.1 | GO:0008053 | mitochondrial fusion(GO:0008053) |
0.0 | 0.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
0.0 | 2.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 2.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.2 | GO:0071476 | hypotonic response(GO:0006971) cellular hypotonic response(GO:0071476) |
0.0 | 0.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.0 | 0.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.0 | 0.2 | GO:0060013 | righting reflex(GO:0060013) |
0.0 | 1.3 | GO:0007601 | visual perception(GO:0007601) |
0.0 | 0.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.2 | GO:0031280 | negative regulation of cyclase activity(GO:0031280) |
0.0 | 1.7 | GO:0006333 | chromatin assembly or disassembly(GO:0006333) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 6.4 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.3 | 1.0 | GO:0031673 | H zone(GO:0031673) |
0.2 | 1.8 | GO:0044327 | dendritic spine head(GO:0044327) |
0.2 | 1.8 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 3.4 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.2 | 2.7 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.2 | 1.5 | GO:0070688 | MLL5-L complex(GO:0070688) |
0.2 | 0.5 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
0.2 | 2.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.1 | 1.3 | GO:0005922 | connexon complex(GO:0005922) |
0.1 | 1.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.1 | 2.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 1.1 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 0.4 | GO:0042589 | zymogen granule membrane(GO:0042589) |
0.0 | 0.4 | GO:0005687 | U4 snRNP(GO:0005687) |
0.0 | 0.6 | GO:0005839 | proteasome core complex(GO:0005839) |
0.0 | 1.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.0 | 0.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.0 | 0.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
0.4 | 1.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.3 | 6.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.2 | 2.7 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.2 | 1.1 | GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043) |
0.2 | 2.0 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
0.2 | 1.8 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
0.2 | 2.4 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 1.0 | GO:0050253 | prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032) |
0.0 | 1.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.4 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
0.0 | 0.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 1.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.0 | 0.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.0 | 0.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.0 | 0.5 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.0 | 0.1 | GO:0033691 | sialic acid binding(GO:0033691) |
0.0 | 0.5 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.0 | 0.1 | GO:0050692 | DBD domain binding(GO:0050692) |
0.0 | 0.0 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity(GO:0008176) |
0.0 | 0.9 | GO:0043851 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012) |
0.0 | 5.5 | GO:0005509 | calcium ion binding(GO:0005509) |
0.0 | 1.3 | GO:0030165 | PDZ domain binding(GO:0030165) |