Motif ID: Maff

Z-value: 0.649


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79348061_793481540.482.5e-05Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_3270767 6.049 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr16_-_22439719 5.789 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr13_-_23710714 4.662 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr4_-_136886187 4.569 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr17_-_25570678 4.509 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr14_+_118787894 3.831 ENSMUST00000047761.6
ENSMUST00000071546.7
 Cldn10

claudin 10

chr7_-_110862944 3.631 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr4_-_143299463 2.945 ENSMUST00000119654.1
 Pdpn
podoplanin
chr4_-_143299498 2.874 ENSMUST00000030317.7
 Pdpn
podoplanin
chr11_-_109473598 2.788 ENSMUST00000070152.5
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr13_+_48261427 2.598 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr5_+_104435112 2.239 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr1_+_136018062 2.154 ENSMUST00000117950.1
 Tmem9
transmembrane protein 9
chr1_+_136017967 2.147 ENSMUST00000063719.8
ENSMUST00000118832.1
 Tmem9

transmembrane protein 9

chr1_-_120074023 1.879 ENSMUST00000056089.7
 Tmem37
transmembrane protein 37
chr5_-_135251209 1.854 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr4_+_102421518 1.841 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_130397525 1.756 ENSMUST00000028897.7
 Cpxm1
carboxypeptidase X 1 (M14 family)
chr18_+_4921662 1.714 ENSMUST00000143254.1
 Svil
supervillin
chr7_+_84528964 1.675 ENSMUST00000180387.1
 Gm2115
predicted gene 2115
chr19_-_57197556 1.668 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr6_+_120773633 1.598 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr19_+_56722372 1.589 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr10_-_88605017 1.481 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr11_+_82101836 1.459 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr9_-_111690313 1.404 ENSMUST00000035083.7
 Stac
src homology three (SH3) and cysteine rich domain
chr17_+_86963279 1.225 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr17_-_67950908 1.208 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr18_+_60963517 1.120 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr1_+_75382114 1.120 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr5_-_67815852 1.068 ENSMUST00000141443.1
 Atp8a1
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr3_-_59262825 1.040 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr3_+_65109343 1.010 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr5_+_106964319 0.965 ENSMUST00000031221.5
ENSMUST00000117196.2
ENSMUST00000076467.6
 Cdc7


cell division cycle 7 (S. cerevisiae)


chr11_+_75651504 0.953 ENSMUST00000069057.6
 Myo1c
myosin IC
chr14_+_20929416 0.950 ENSMUST00000022369.7
 Vcl
vinculin
chr19_+_8929628 0.887 ENSMUST00000096241.4
 Eml3
echinoderm microtubule associated protein like 3
chr9_+_65214690 0.874 ENSMUST00000069000.7
 Parp16
poly (ADP-ribose) polymerase family, member 16
chr5_+_8056527 0.865 ENSMUST00000148633.1
 Sri
sorcin
chr1_-_136260873 0.840 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr4_+_141239499 0.774 ENSMUST00000141834.2
 Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr5_+_7179299 0.641 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr5_+_140505550 0.604 ENSMUST00000043050.8
ENSMUST00000124142.1
 Chst12

carbohydrate sulfotransferase 12

chr19_-_8929323 0.572 ENSMUST00000096242.3
 Rom1
rod outer segment membrane protein 1
chr3_-_108044801 0.556 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
 Gstm4


glutathione S-transferase, mu 4


chr8_+_25532125 0.506 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr7_-_44997535 0.492 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr4_-_25281801 0.478 ENSMUST00000102994.3
 Ufl1
UFM1 specific ligase 1
chr4_-_25281752 0.478 ENSMUST00000038705.7
 Ufl1
UFM1 specific ligase 1
chr10_-_121626316 0.384 ENSMUST00000039810.7
 Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr6_+_30401866 0.336 ENSMUST00000068240.6
ENSMUST00000068259.6
 Klhdc10

kelch domain containing 10

chr3_+_109573907 0.313 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr19_-_4042165 0.303 ENSMUST00000042700.9
 Gstp2
glutathione S-transferase, pi 2
chr5_+_110839973 0.244 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr2_+_121866918 0.201 ENSMUST00000078752.3
ENSMUST00000110586.3
 Casc4

cancer susceptibility candidate 4

chr2_+_121867083 0.178 ENSMUST00000089912.5
ENSMUST00000089915.3
 Casc4

cancer susceptibility candidate 4

chr5_+_103754560 0.149 ENSMUST00000153165.1
ENSMUST00000031256.5
 Aff1

AF4/FMR2 family, member 1

chr3_+_28805436 0.146 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1
chr7_-_4684963 0.146 ENSMUST00000079970.4
 Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr7_-_64925560 0.078 ENSMUST00000149851.1
 Fam189a1
family with sequence similarity 189, member A1
chr7_-_100964371 0.062 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr11_+_76945719 0.058 ENSMUST00000125145.1
 Blmh
bleomycin hydrolase
chr10_+_62920630 0.050 ENSMUST00000044977.3
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr11_-_116086929 0.048 ENSMUST00000074628.6
ENSMUST00000106444.3
 Wbp2

WW domain binding protein 2

chr15_-_78572754 0.044 ENSMUST00000043214.6
 Rac2
RAS-related C3 botulinum substrate 2
chr4_-_139352298 0.038 ENSMUST00000030513.6
ENSMUST00000155257.1
 Mrto4

MRT4, mRNA turnover 4, homolog (S. cerevisiae)

chr13_+_66932802 0.029 ENSMUST00000021990.3
 Ptdss1
phosphatidylserine synthase 1
chr15_-_33687840 0.009 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
1.5 4.5 GO:0072034 renal vesicle induction(GO:0072034)
1.2 5.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 6.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.6 2.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.6 5.8 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.5 1.6 GO:1900133 renin secretion into blood stream(GO:0002001) negative regulation of urine volume(GO:0035811) regulation of renin secretion into blood stream(GO:1900133)
0.5 1.5 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.5 3.6 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.3 1.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.3 1.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 4.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 2.2 GO:0033280 response to vitamin D(GO:0033280)
0.2 0.9 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 1.0 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 1.0 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 0.7 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.2 2.7 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.2 1.0 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 1.1 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 2.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.4 GO:0051031 tRNA transport(GO:0051031)
0.1 1.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.1 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 0.6 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.1 1.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 1.2 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 0.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.1 1.0 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.6 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 1.9 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 1.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 1.1 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 1.9 GO:0070588 calcium ion transmembrane transport(GO:0070588)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:1990357 terminal web(GO:1990357)
0.3 1.0 GO:0045160 myosin I complex(GO:0045160)
0.3 0.9 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 1.0 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.1 1.0 GO:0005916 fascia adherens(GO:0005916)
0.1 1.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 4.6 GO:0005581 collagen trimer(GO:0005581)
0.1 1.7 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 5.8 GO:0001726 ruffle(GO:0001726)
0.0 4.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 3.4 GO:0005770 late endosome(GO:0005770)
0.0 1.3 GO:0005884 actin filament(GO:0005884)
0.0 10.3 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0051379 epinephrine binding(GO:0051379)
0.5 5.8 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.5 4.7 GO:0039706 co-receptor binding(GO:0039706)
0.4 6.0 GO:0008430 selenium binding(GO:0008430)
0.4 1.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.3 1.0 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 3.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 0.6 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 1.2 GO:0005522 profilin binding(GO:0005522)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.0 GO:0070402 NADPH binding(GO:0070402)
0.1 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 4.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.8 GO:0030552 cAMP binding(GO:0030552)
0.0 2.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 1.9 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.6 GO:0015293 symporter activity(GO:0015293)
0.0 0.4 GO:0015932 nucleobase-containing compound transmembrane transporter activity(GO:0015932)
0.0 0.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)