Motif ID: Max_Mycn

Z-value: 3.193

Transcription factors associated with Max_Mycn:

Gene SymbolEntrez IDGene Name
Max ENSMUSG00000059436.6 Max
Mycn ENSMUSG00000037169.8 Mycn

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maxmm10_v2_chr12_-_76962178_76962248-0.491.4e-05Click!
Mycnmm10_v2_chr12_-_12941827_12941914-0.123.4e-01Click!


Activity profile for motif Max_Mycn.

activity profile for motif Max_Mycn


Sorted Z-values histogram for motif Max_Mycn

Sorted Z-values for motif Max_Mycn



Network of associatons between targets according to the STRING database.



First level regulatory network of Max_Mycn

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_144896523 37.625 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr4_-_137796350 34.558 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr4_-_143299498 33.648 ENSMUST00000030317.7
 Pdpn
podoplanin
chr4_-_143299463 33.276 ENSMUST00000119654.1
 Pdpn
podoplanin
chr7_-_103843154 33.082 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr12_+_117843873 32.205 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr5_+_140607334 32.096 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_-_12026732 31.105 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr10_+_127063599 31.073 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr10_+_79854618 29.925 ENSMUST00000165704.1
 Ptbp1
polypyrimidine tract binding protein 1
chr12_+_17544873 28.921 ENSMUST00000171737.1
 Odc1
ornithine decarboxylase, structural 1
chr8_+_27260327 27.420 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr10_-_77113676 27.270 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr5_-_76951560 26.728 ENSMUST00000140076.1
 Ppat
phosphoribosyl pyrophosphate amidotransferase
chr11_-_94601862 26.004 ENSMUST00000103164.3
 Acsf2
acyl-CoA synthetase family member 2
chr2_+_156840966 25.913 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr3_+_104638658 25.588 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr11_-_60811228 25.339 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chrX_-_141725181 25.319 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr10_+_79854658 25.000 ENSMUST00000171599.1
ENSMUST00000095457.4
 Ptbp1

polypyrimidine tract binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 678 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 86.8 GO:0006414 translational elongation(GO:0006414)
5.9 82.2 GO:0002192 IRES-dependent translational initiation(GO:0002192)
0.7 79.2 GO:0051028 mRNA transport(GO:0051028)
12.0 72.0 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
7.5 67.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
6.7 66.9 GO:0010572 positive regulation of platelet activation(GO:0010572)
1.0 56.6 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
13.6 54.3 GO:0010288 response to lead ion(GO:0010288)
1.5 52.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
3.8 52.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
3.5 52.6 GO:0010216 maintenance of DNA methylation(GO:0010216)
2.6 51.1 GO:0006220 pyrimidine nucleotide metabolic process(GO:0006220)
2.0 48.9 GO:0006907 pinocytosis(GO:0006907)
9.6 47.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.4 40.8 GO:0006626 protein targeting to mitochondrion(GO:0006626)
9.8 39.3 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
3.8 38.1 GO:0046036 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
5.2 36.6 GO:0043504 mitochondrial DNA repair(GO:0043504)
2.1 36.3 GO:0038092 nodal signaling pathway(GO:0038092)
2.2 34.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 289 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 256.4 GO:0005730 nucleolus(GO:0005730)
0.2 210.8 GO:0005739 mitochondrion(GO:0005739)
0.1 126.5 GO:0005576 extracellular region(GO:0005576)
2.2 102.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 100.8 GO:0005925 focal adhesion(GO:0005925)
1.8 86.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.6 85.8 GO:0000791 euchromatin(GO:0000791)
0.1 81.6 GO:0005829 cytosol(GO:0005829)
7.4 74.3 GO:0005642 annulate lamellae(GO:0005642)
0.3 68.5 GO:0031012 extracellular matrix(GO:0031012)
0.9 64.1 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 63.8 GO:0005667 transcription factor complex(GO:0005667)
0.7 62.4 GO:0030175 filopodium(GO:0030175)
10.1 60.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
4.2 59.0 GO:0035686 sperm fibrous sheath(GO:0035686)
1.1 58.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.7 51.1 GO:0005604 basement membrane(GO:0005604)
0.6 48.5 GO:0016363 nuclear matrix(GO:0016363)
0.7 46.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 44.0 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 427 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 176.7 GO:0044822 poly(A) RNA binding(GO:0044822)
1.8 83.0 GO:0016831 carboxy-lyase activity(GO:0016831)
3.3 78.0 GO:0003746 translation elongation factor activity(GO:0003746)
5.5 72.1 GO:0017070 U6 snRNA binding(GO:0017070)
1.5 69.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
6.2 68.5 GO:0008517 folic acid transporter activity(GO:0008517)
0.3 68.3 GO:0003735 structural constituent of ribosome(GO:0003735)
3.0 66.2 GO:0001784 phosphotyrosine binding(GO:0001784)
11.0 54.9 GO:0001069 regulatory region RNA binding(GO:0001069)
1.0 52.8 GO:0003725 double-stranded RNA binding(GO:0003725)
1.3 49.8 GO:0008536 Ran GTPase binding(GO:0008536)
3.9 47.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.7 44.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
14.8 44.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
8.5 42.3 GO:0030492 hemoglobin binding(GO:0030492)
2.3 42.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
3.8 41.5 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
10.3 41.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
5.7 40.1 GO:0034452 dynactin binding(GO:0034452)
2.2 39.7 GO:0051920 peroxiredoxin activity(GO:0051920)