Motif ID: Mecom

Z-value: 0.558


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 13.855 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr7_-_103853199 7.071 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr6_+_138140298 5.995 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chr8_+_12385769 4.149 ENSMUST00000080795.8
 Gm5607
predicted gene 5607
chr14_-_52020698 3.586 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr1_+_156838915 2.972 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr13_+_89540636 2.874 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr9_+_65890237 2.797 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chrX_-_145505175 2.237 ENSMUST00000143610.1
 Amot
angiomotin
chrX_-_145505136 2.230 ENSMUST00000112835.1
 Amot
angiomotin
chr1_+_152399824 2.149 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr13_+_104287855 1.954 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr10_+_3740348 1.952 ENSMUST00000120274.1
 Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr3_+_41742615 1.770 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr4_+_11704439 1.663 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr11_-_88718078 1.613 ENSMUST00000092794.5
 Msi2
musashi RNA-binding protein 2
chr5_-_120467296 1.495 ENSMUST00000132916.1
 Sdsl
serine dehydratase-like
chr8_-_18741542 1.473 ENSMUST00000033846.6
 Angpt2
angiopoietin 2
chr18_+_4994600 1.408 ENSMUST00000140448.1
 Svil
supervillin
chr16_-_38713235 1.319 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr1_+_45311538 1.312 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr2_+_71786923 1.249 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr14_+_115042752 1.191 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr9_+_72806874 1.137 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr13_-_103764502 0.997 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr1_+_120006980 0.983 ENSMUST00000072886.4
 Sctr
secretin receptor
chr14_+_55854115 0.974 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr14_+_55853997 0.908 ENSMUST00000100529.3
 Nynrin
NYN domain and retroviral integrase containing
chr2_+_103970115 0.885 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr4_+_128846163 0.866 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr4_-_110292719 0.865 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_+_103970221 0.818 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr12_-_86079019 0.773 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr1_+_107511416 0.718 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr16_-_29541483 0.693 ENSMUST00000057018.8
ENSMUST00000182627.1
 Atp13a4

ATPase type 13A4

chr3_+_36552600 0.666 ENSMUST00000029269.5
ENSMUST00000136890.1
 Exosc9

exosome component 9

chrX_-_113185485 0.633 ENSMUST00000026607.8
ENSMUST00000113388.2
 Chm

choroidermia

chr4_+_41569775 0.612 ENSMUST00000102963.3
 Dnaic1
dynein, axonemal, intermediate chain 1
chrX_+_9885622 0.606 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr1_+_107511489 0.541 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr11_-_60046477 0.525 ENSMUST00000000310.7
ENSMUST00000102693.2
ENSMUST00000148512.1
 Pemt


phosphatidylethanolamine N-methyltransferase


chr1_-_69685937 0.485 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chr5_+_134582690 0.411 ENSMUST00000023867.6
 Rfc2
replication factor C (activator 1) 2
chr14_+_34375504 0.381 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr13_+_49544443 0.380 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr10_-_6980376 0.358 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr9_+_115909455 0.348 ENSMUST00000119291.1
ENSMUST00000069651.6
 Gadl1

glutamate decarboxylase-like 1

chr2_+_103969528 0.333 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr9_+_105053239 0.318 ENSMUST00000035177.8
ENSMUST00000149243.1
 Mrpl3

mitochondrial ribosomal protein L3

chr10_+_5593718 0.318 ENSMUST00000051809.8
 Myct1
myc target 1
chrX_+_169879596 0.301 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr5_+_65131184 0.285 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr3_+_106034661 0.261 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr9_-_13245741 0.189 ENSMUST00000110582.2
 Jrkl
jerky homolog-like (mouse)
chr2_-_149798701 0.165 ENSMUST00000148202.1
ENSMUST00000139471.1
 Gm14133

predicted gene 14133

chr7_+_82337218 0.120 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chrX_-_139871637 0.102 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr18_-_43477764 0.055 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr5_+_66259890 0.038 ENSMUST00000065530.6
 Nsun7
NOL1/NOP2/Sun domain family, member 7
chr6_+_113392417 0.033 ENSMUST00000032414.4
ENSMUST00000038889.5
 Ttll3

tubulin tyrosine ligase-like family, member 3

chr11_-_50953745 0.033 ENSMUST00000162420.1
ENSMUST00000051159.2
 Prop1

paired like homeodomain factor 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 13.9 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.5 6.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
1.4 7.1 GO:0015671 oxygen transport(GO:0015671)
1.1 4.5 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.5 1.5 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 1.2 GO:0035878 nail development(GO:0035878)
0.3 1.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 0.8 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.2 1.9 GO:0015074 DNA integration(GO:0015074)
0.2 2.8 GO:0019985 translesion synthesis(GO:0019985)
0.2 0.7 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.2 2.0 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.5 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.1 0.6 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 1.6 GO:0048864 stem cell development(GO:0048864)
0.0 1.7 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.4 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 2.0 GO:0035904 aorta development(GO:0035904)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.0 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 2.3 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0060126 hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.1 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 4.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 5.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.7 GO:0051233 spindle midzone(GO:0051233)
0.0 0.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.0 1.6 GO:0005844 polysome(GO:0005844)
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 13.9 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
1.8 7.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.5 4.5 GO:0043532 angiostatin binding(GO:0043532)
0.4 1.5 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.3 6.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 1.2 GO:0038132 neuregulin binding(GO:0038132)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.7 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.1 1.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 2.0 GO:0043425 bHLH transcription factor binding(GO:0043425) E-box binding(GO:0070888)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.1 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.0 3.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)