Motif ID: Mecp2

Z-value: 2.620


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085586_74085652-0.262.8e-02Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_68386821 30.519 ENSMUST00000021284.3
 Ntn1
netrin 1
chr11_+_98412461 27.480 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr6_-_72788952 27.354 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_25250720 26.811 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr11_+_112782182 26.695 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr10_-_42583628 26.640 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_91457501 23.087 ENSMUST00000028689.3
 Lrp4
low density lipoprotein receptor-related protein 4
chr14_-_118237016 22.880 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr11_-_100850724 22.315 ENSMUST00000004143.2
 Stat5b
signal transducer and activator of transcription 5B
chr8_-_87959560 21.876 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_72789240 21.833 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr11_-_89302545 21.713 ENSMUST00000061728.3
 Nog
noggin
chr8_-_90348343 20.873 ENSMUST00000109621.3
 Tox3
TOX high mobility group box family member 3
chr6_+_128362919 20.784 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr11_-_12037391 20.770 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr2_+_59612034 20.691 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr4_+_154960915 20.470 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr5_+_108694222 19.348 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr14_-_67715585 18.725 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr15_-_86033777 18.401 ENSMUST00000016172.7
 Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,096 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.4 50.4 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
15.6 46.8 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
5.0 45.4 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
1.4 41.8 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
6.4 38.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
6.0 36.2 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
3.2 34.9 GO:0061032 visceral serous pericardium development(GO:0061032)
5.0 34.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.5 34.1 GO:0006270 DNA replication initiation(GO:0006270)
5.6 33.5 GO:0090193 positive regulation of glomerulus development(GO:0090193)
0.7 33.0 GO:0051225 spindle assembly(GO:0051225)
0.3 32.0 GO:0051028 mRNA transport(GO:0051028)
1.5 31.5 GO:0071539 protein localization to centrosome(GO:0071539)
2.1 31.1 GO:0030953 astral microtubule organization(GO:0030953)
10.3 30.9 GO:0072034 renal vesicle induction(GO:0072034)
0.9 29.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
5.9 29.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
3.0 29.5 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
2.5 29.4 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
9.5 28.5 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 341 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 400.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 142.8 GO:0005634 nucleus(GO:0005634)
0.1 138.6 GO:0005654 nucleoplasm(GO:0005654)
0.3 92.1 GO:0005925 focal adhesion(GO:0005925)
0.5 92.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 77.4 GO:0005730 nucleolus(GO:0005730)
0.1 71.0 GO:1903561 extracellular organelle(GO:0043230) extracellular vesicle(GO:1903561)
5.1 66.0 GO:0043219 lateral loop(GO:0043219)
0.9 58.9 GO:0005844 polysome(GO:0005844)
2.6 57.1 GO:0001741 XY body(GO:0001741)
0.9 51.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 47.5 GO:0005604 basement membrane(GO:0005604)
1.0 46.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 45.4 GO:0000922 spindle pole(GO:0000922)
2.9 43.0 GO:0016600 flotillin complex(GO:0016600)
5.3 37.4 GO:0000796 condensin complex(GO:0000796)
11.6 34.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
6.5 32.5 GO:0097149 centralspindlin complex(GO:0097149)
2.7 32.0 GO:0070938 contractile ring(GO:0070938)
1.1 30.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 583 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 213.9 GO:0001067 regulatory region DNA binding(GO:0000975) regulatory region nucleic acid binding(GO:0001067)
0.7 141.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
1.0 138.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.6 56.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.0 55.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 49.7 GO:0003677 DNA binding(GO:0003677)
0.5 47.9 GO:0005178 integrin binding(GO:0005178)
5.7 45.4 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
1.2 45.3 GO:0030332 cyclin binding(GO:0030332)
2.6 41.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
2.4 40.0 GO:0017166 vinculin binding(GO:0017166)
1.1 37.9 GO:0071837 HMG box domain binding(GO:0071837)
1.4 36.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
5.1 35.6 GO:0034056 estrogen response element binding(GO:0034056)
3.5 34.7 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
1.6 34.7 GO:0008266 poly(U) RNA binding(GO:0008266)
3.8 33.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.0 31.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 31.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.5 30.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)