Motif ID: Mef2d_Mef2a

Z-value: 1.083

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2amm10_v2_chr7_-_67372846_673728580.713.9e-12Click!
Mef2dmm10_v2_chr3_+_88142328_881424830.681.0e-10Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 19.608 ENSMUST00000185052.1
Mef2c
myocyte enhancer factor 2C
chr11_+_31872100 14.226 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr9_-_112232449 12.394 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr19_+_38264761 12.326 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr3_-_56183678 11.535 ENSMUST00000029374.6
Nbea
neurobeachin
chr1_-_134234492 11.473 ENSMUST00000169927.1
Adora1
adenosine A1 receptor
chr13_-_113663670 10.848 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr13_+_5861489 10.689 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr6_-_136171722 10.568 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr5_+_24985840 10.460 ENSMUST00000075081.6
1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr16_+_7069825 10.291 ENSMUST00000056416.7
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr9_+_34904913 10.283 ENSMUST00000045091.6
Kirrel3
kin of IRRE like 3 (Drosophila)
chr2_-_168712853 9.374 ENSMUST00000123156.1
ENSMUST00000156555.1
Atp9a

ATPase, class II, type 9A

chr7_+_91090697 9.082 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 8.858 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr1_-_64122256 8.564 ENSMUST00000135075.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr2_-_33371486 8.247 ENSMUST00000113165.1
Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr18_-_25753852 8.152 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4

CUGBP, Elav-like family member 4

chr2_-_33371400 7.794 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr10_+_90576872 7.720 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 27.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
6.5 19.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.3 17.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.4 17.8 GO:0034605 cellular response to heat(GO:0034605)
3.2 16.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
5.0 14.9 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 14.3 GO:0001578 microtubule bundle formation(GO:0001578)
2.2 13.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 12.9 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
3.8 11.5 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 10.8 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
2.1 10.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 10.3 GO:0006342 chromatin silencing(GO:0006342)
0.2 9.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.1 8.9 GO:0016081 synaptic vesicle docking(GO:0016081)
1.7 8.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.4 8.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.2 8.2 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.4 8.0 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 8.0 GO:0048813 dendrite morphogenesis(GO:0048813)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 22.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.3 20.1 GO:0014704 intercalated disc(GO:0014704)
0.9 17.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 17.6 GO:0045202 synapse(GO:0045202)
0.3 16.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 15.6 GO:0016607 nuclear speck(GO:0016607)
0.1 13.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.7 11.5 GO:0032279 asymmetric synapse(GO:0032279)
0.1 11.4 GO:0031225 anchored component of membrane(GO:0031225)
1.0 10.6 GO:0043083 synaptic cleft(GO:0043083)
0.1 10.4 GO:0043198 dendritic shaft(GO:0043198)
0.2 9.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 8.3 GO:0005903 brush border(GO:0005903)
2.0 8.2 GO:0090537 CERF complex(GO:0090537)
0.1 8.0 GO:0016605 PML body(GO:0016605)
2.6 7.9 GO:0043512 inhibin A complex(GO:0043512)
0.4 7.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 7.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.8 6.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 6.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 19.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
1.2 18.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
3.0 18.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.9 17.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 16.4 GO:0051018 protein kinase A binding(GO:0051018)
0.1 15.1 GO:0008017 microtubule binding(GO:0008017)
0.8 15.0 GO:0030275 LRR domain binding(GO:0030275)
2.3 13.7 GO:0070699 type II activin receptor binding(GO:0070699)
1.2 13.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.4 13.5 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 13.1 GO:0003729 mRNA binding(GO:0003729)
0.1 12.5 GO:0005516 calmodulin binding(GO:0005516)
1.6 11.5 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 11.3 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.5 10.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
2.1 8.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
2.7 8.2 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.1 7.7 GO:0030674 protein binding, bridging(GO:0030674)
0.4 7.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 7.4 GO:0017080 sodium channel regulator activity(GO:0017080)