Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.724

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lmx1amm10_v2_chr1_+_167689108_1676892390.517.8e-06Click!
Lhx6mm10_v2_chr2_-_36105271_36105434-0.028.9e-01Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_61902669 12.924 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr2_+_20737306 10.926 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr5_+_139543889 8.875 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr15_+_25773985 6.217 ENSMUST00000125667.1
 Myo10
myosin X
chr2_+_25372315 6.099 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr14_-_118052235 5.660 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr9_+_65890237 5.377 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr3_-_88410295 5.124 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr9_+_118478344 4.558 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 4.247 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_-_172027269 4.208 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr14_-_48665098 4.155 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr5_+_92809372 4.080 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr4_-_97778042 4.041 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr6_-_147264124 3.753 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr7_-_49636847 3.664 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr5_-_62766153 3.511 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_60893430 3.371 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr11_-_3931960 3.301 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr2_-_72986716 3.266 ENSMUST00000112062.1
 Gm11084
predicted gene 11084

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
1.2 9.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.9 8.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 8.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
2.2 6.6 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 6.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
2.1 6.3 GO:0015889 cobalamin transport(GO:0015889)
1.4 5.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.9 5.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 5.6 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.4 5.4 GO:0019985 translesion synthesis(GO:0019985)
0.2 4.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 4.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.6 3.8 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.3 3.7 GO:0060539 diaphragm development(GO:0060539)
0.2 3.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 3.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.7 3.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 3.4 GO:0007530 sex determination(GO:0007530)
0.0 3.1 GO:0043488 regulation of mRNA stability(GO:0043488)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 12.9 GO:0002102 podosome(GO:0002102)
0.0 11.1 GO:0005615 extracellular space(GO:0005615)
0.1 7.4 GO:0070469 respiratory chain(GO:0070469)
1.7 6.6 GO:0060187 cell pole(GO:0060187)
0.1 6.2 GO:0016459 myosin complex(GO:0016459)
0.0 5.8 GO:0043296 apical junction complex(GO:0043296)
0.2 5.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 5.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.9 5.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 5.0 GO:0000792 heterochromatin(GO:0000792)
0.2 3.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.7 GO:0000776 kinetochore(GO:0000776)
0.5 2.6 GO:0008623 CHRAC(GO:0008623)
0.1 2.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.9 GO:0016607 nuclear speck(GO:0016607)
0.3 1.7 GO:0031523 Myb complex(GO:0031523)
0.1 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 1.6 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.7 GO:0003779 actin binding(GO:0003779)
0.0 14.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 8.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 7.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 6.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.9 6.3 GO:0031419 cobalamin binding(GO:0031419)
0.4 5.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 5.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 4.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 4.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 4.2 GO:0030507 spectrin binding(GO:0030507)
0.2 4.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.9 GO:0005109 frizzled binding(GO:0005109)
0.4 3.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.5 3.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 3.4 GO:0008483 transaminase activity(GO:0008483)
0.1 3.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 3.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.9 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)