Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.590

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx9mm10_v2_chr1_-_138848576_138848603-0.422.5e-04Click!
Raxmm10_v2_chr18_-_65939048_65939089-0.263.2e-02Click!
Dlx6mm10_v2_chr6_+_6863269_68633340.047.7e-01Click!
Msx1mm10_v2_chr5_-_37824580_378245840.019.1e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_134747241 8.297 ENSMUST00000015138.9
 Eln
elastin
chr2_+_116067213 5.904 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_-_62766153 5.739 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_+_42907563 4.477 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr2_-_116067391 4.075 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr9_-_40346290 3.685 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr1_-_155417394 3.366 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr3_-_49757257 3.247 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr11_-_98053415 3.247 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr12_-_83487708 3.095 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr9_+_118478344 3.035 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 2.928 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr19_+_26749726 2.884 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_104768510 2.700 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr6_-_136171722 2.633 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr14_-_118052235 2.618 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr16_+_45093611 2.587 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr1_-_155417283 2.470 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr17_-_49564262 2.264 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr8_+_54954728 2.252 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
2.0 6.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.0 5.8 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 4.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 4.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.4 3.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 3.2 GO:0098792 xenophagy(GO:0098792)
0.1 2.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.4 2.6 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.2 2.6 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.6 2.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 2.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 2.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 2.3 GO:0007368 determination of left/right symmetry(GO:0007368)
0.7 2.0 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.4 2.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 2.0 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.3 1.9 GO:0019532 oxalate transport(GO:0019532)
0.6 1.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 8.3 GO:0071953 elastic fiber(GO:0071953)
0.3 6.7 GO:0071565 nBAF complex(GO:0071565)
0.0 2.9 GO:0031201 SNARE complex(GO:0031201)
0.2 2.6 GO:0043083 synaptic cleft(GO:0043083)
0.2 2.6 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.4 GO:0043205 fibril(GO:0043205)
0.1 2.0 GO:0097440 apical dendrite(GO:0097440)
0.1 1.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.0 1.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.0 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.3 0.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 0.7 GO:0097433 dense body(GO:0097433)
0.0 0.7 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 0.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 7.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 6.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 5.8 GO:0001618 virus receptor activity(GO:0001618)
0.1 3.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 2.9 GO:0019905 syntaxin binding(GO:0019905)
0.3 2.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.2 2.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 2.6 GO:0001968 fibronectin binding(GO:0001968)
0.5 2.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 2.3 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.4 2.0 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.7 GO:0050693 LBD domain binding(GO:0050693)
0.0 1.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.6 GO:0002039 p53 binding(GO:0002039)
0.0 1.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.3 GO:0070412 R-SMAD binding(GO:0070412)