Motif ID: Msx2_Hoxd4

Z-value: 0.991

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.226.5e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 13.812 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_36811361 8.581 ENSMUST00000101534.1
Ptn
pleiotrophin
chr2_+_4017727 6.971 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr1_+_159737510 6.766 ENSMUST00000111669.3
Tnr
tenascin R
chr3_+_62419668 6.629 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr14_-_88471396 5.987 ENSMUST00000061628.5
Pcdh20
protocadherin 20
chr2_-_63184253 5.761 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr5_-_62765618 5.620 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_21111452 5.345 ENSMUST00000075132.6
Cdh12
cadherin 12
chr1_-_190170671 5.296 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr15_-_79285502 4.411 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr1_-_190170178 4.061 ENSMUST00000177288.1
Prox1
prospero-related homeobox 1
chr11_+_103133333 3.668 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2

hexamethylene bis-acetamide inducible 2

chr12_+_74297474 3.590 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr11_+_103133303 3.583 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chr17_-_90088343 3.565 ENSMUST00000173917.1
Nrxn1
neurexin I
chr1_-_163725123 3.526 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr2_-_63184170 3.468 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr3_-_85741389 3.361 ENSMUST00000094148.4
Fam160a1
family with sequence similarity 160, member A1
chr1_+_165788681 2.984 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen




Gene overrepresentation in biological_process category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.1 9.4 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 9.2 GO:0051291 protein heterooligomerization(GO:0051291)
2.9 8.6 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.2 7.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
2.3 6.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 6.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 6.4 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.1 6.1 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 5.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 4.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 4.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.7 3.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 3.5 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.2 2.9 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 2.8 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.9 2.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 2.7 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.8 2.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.0 2.4 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 7.0 GO:0005923 bicellular tight junction(GO:0005923)
2.3 6.8 GO:0072534 perineuronal net(GO:0072534)
1.4 5.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.4 4.4 GO:0071439 clathrin complex(GO:0071439)
0.1 3.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.2 GO:0005911 cell-cell junction(GO:0005911)
0.3 2.9 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.3 2.7 GO:0070688 MLL5-L complex(GO:0070688)
0.3 2.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 2.5 GO:0070469 respiratory chain(GO:0070469)
0.0 1.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.7 GO:0071564 npBAF complex(GO:0071564)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 15.9 GO:0005509 calcium ion binding(GO:0005509)
1.2 9.4 GO:0050693 LBD domain binding(GO:0050693)
0.5 9.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
2.9 8.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.0 7.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 7.0 GO:0030674 protein binding, bridging(GO:0030674)
0.5 6.8 GO:0046625 sphingolipid binding(GO:0046625)
0.1 4.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 4.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 3.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 3.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.3 2.9 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.2 2.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.9 2.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 2.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.4 2.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 2.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)