Motif ID: Msx2_Hoxd4
Z-value: 0.991
Transcription factors associated with Msx2_Hoxd4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Msx2 | ENSMUSG00000021469.8 | Msx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Msx2 | mm10_v2_chr13_-_53473074_53473074 | -0.22 | 6.5e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.4 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 2.9 | 8.6 | GO:1904395 | regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 2.3 | 6.8 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.9 | 2.7 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.8 | 2.5 | GO:0030827 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.7 | 3.6 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.4 | 2.7 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.3 | 1.4 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
| 0.3 | 1.3 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.3 | 4.4 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.3 | 0.9 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.3 | 6.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.3 | 1.7 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
| 0.3 | 1.2 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.3 | 0.8 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.2 | 1.8 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
| 0.2 | 5.7 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
| 0.2 | 1.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.2 | 0.6 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.2 | 2.9 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.2 | 1.7 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 0.3 | GO:0003273 | cell migration involved in endocardial cushion formation(GO:0003273) |
| 0.2 | 13.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 7.0 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.2 | 0.5 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) |
| 0.1 | 1.6 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 6.1 | GO:1904030 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.1 | 2.1 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.1 | 2.0 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 1.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.3 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 1.9 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
| 0.1 | 3.5 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.1 | 1.5 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 0.5 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.1 | 1.0 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.1 | 0.6 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.7 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 6.4 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.1 | 2.1 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.1 | 1.3 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.1 | 2.2 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.1 | 0.4 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.1 | 2.2 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.1 | 1.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 0.3 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.1 | 1.2 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 9.2 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.1 | 0.9 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 4.1 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.1 | 1.0 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 0.5 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.0 | 0.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 2.8 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 1.4 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.3 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.0 | 0.2 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.0 | 0.4 | GO:0060746 | parental behavior(GO:0060746) |
| 0.0 | 0.5 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 0.7 | GO:0071398 | cellular response to fatty acid(GO:0071398) |
| 0.0 | 0.6 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.0 | 0.6 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.7 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.0 | 0.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.0 | 2.4 | GO:0098780 | mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780) |
| 0.0 | 0.6 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.0 | 0.3 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.1 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 1.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 6.8 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.4 | 5.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.4 | 4.4 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.3 | 2.7 | GO:0070688 | MLL5-L complex(GO:0070688) |
| 0.3 | 2.5 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.3 | 2.9 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 0.7 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 0.5 | GO:0055087 | Ski complex(GO:0055087) |
| 0.2 | 0.8 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.2 | 0.5 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.2 | 0.6 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 8.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 1.7 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 0.6 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 0.5 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.1 | 0.7 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.9 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.1 | 3.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 1.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 7.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.0 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.2 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.0 | 2.8 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 1.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 2.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.0 | 0.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.5 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 0.3 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.1 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 3.2 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.0 | 12.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 1.2 | GO:0015630 | microtubule cytoskeleton(GO:0015630) |
| 0.0 | 1.1 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.6 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 1.2 | 9.4 | GO:0050693 | LBD domain binding(GO:0050693) |
| 1.0 | 7.3 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.9 | 2.7 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.5 | 9.2 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.5 | 6.8 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.4 | 19.4 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.4 | 2.2 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.3 | 3.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 2.9 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.2 | 1.0 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 2.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.2 | 1.5 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.2 | 1.3 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 4.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 1.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 0.6 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 4.1 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.3 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 1.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 2.1 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 2.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 7.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 0.7 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.6 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.1 | 0.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 1.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.2 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.8 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.2 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 1.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 15.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.0 | 0.9 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.2 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.0 | 0.6 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
| 0.0 | 3.1 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.0 | 0.7 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 2.3 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 1.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.1 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.0 | GO:0015232 | heme transporter activity(GO:0015232) |
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