Motif ID: Msx3

Z-value: 0.435


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049140_1400491800.244.3e-02Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_53975246 6.228 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chrX_-_143933204 4.174 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 3.721 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_-_45117349 3.510 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr1_-_158356258 3.098 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr5_+_14514918 2.838 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr4_-_14621805 2.578 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr10_+_81257277 2.508 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr15_+_82252397 2.474 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr13_+_83732438 2.377 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_+_125136692 2.371 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr10_+_39612934 2.359 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr5_+_88583527 2.255 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr15_+_44787746 2.197 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr1_-_52190901 2.083 ENSMUST00000156887.1
ENSMUST00000129107.1
 Gls

glutaminase

chr2_-_33087169 1.974 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr18_+_37819543 1.879 ENSMUST00000055935.5
 Pcdhga9
protocadherin gamma subfamily A, 9
chr9_-_15301555 1.865 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr7_-_127895578 1.853 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr11_+_70018421 1.785 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr2_-_33086366 1.767 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr4_+_102254739 1.693 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr16_+_11406618 1.680 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr10_+_88379217 1.505 ENSMUST00000130301.1
ENSMUST00000020251.8
 Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr17_+_21383725 1.449 ENSMUST00000056107.4
ENSMUST00000162659.1
 Zfp677

zinc finger protein 677

chr6_+_134640940 1.442 ENSMUST00000062755.8
 Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr4_-_14621494 1.425 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr7_+_3645267 1.407 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr3_-_116253467 1.293 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr12_+_72441852 1.227 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr9_+_44398176 1.060 ENSMUST00000165839.1
 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr3_+_94837533 1.055 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr10_+_88379127 0.997 ENSMUST00000127615.1
 Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr8_+_72219726 0.992 ENSMUST00000003123.8
 Fam32a
family with sequence similarity 32, member A
chr8_+_107031218 0.933 ENSMUST00000034388.9
 Vps4a
vacuolar protein sorting 4a (yeast)
chr12_+_72441933 0.914 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr7_+_103550368 0.880 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr4_-_129378116 0.839 ENSMUST00000030610.2
 Zbtb8a
zinc finger and BTB domain containing 8a
chr7_-_99141068 0.815 ENSMUST00000037968.8
 Uvrag
UV radiation resistance associated gene
chr4_-_14621669 0.812 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chrX_-_75578188 0.811 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr13_+_67863324 0.753 ENSMUST00000078471.5
 BC048507
cDNA sequence BC048507
chr11_+_116843278 0.737 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chrM_+_9870 0.731 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr2_+_121956411 0.662 ENSMUST00000110578.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr18_+_57468478 0.620 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr10_-_85127977 0.589 ENSMUST00000050813.2
 Mterfd3
MTERF domain containing 3
chr11_+_53433299 0.545 ENSMUST00000018382.6
 Gdf9
growth differentiation factor 9
chr17_-_24527830 0.530 ENSMUST00000176353.1
ENSMUST00000176237.1
 Traf7

TNF receptor-associated factor 7

chr2_+_121956651 0.526 ENSMUST00000110574.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr16_-_75766758 0.514 ENSMUST00000114244.1
ENSMUST00000046283.8
 Hspa13

heat shock protein 70 family, member 13

chr17_-_24527925 0.497 ENSMUST00000176652.1
 Traf7
TNF receptor-associated factor 7
chr3_+_94837702 0.461 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr15_+_38661904 0.433 ENSMUST00000022904.6
 Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr12_+_102128718 0.318 ENSMUST00000159329.1
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr12_+_71136848 0.285 ENSMUST00000149564.1
ENSMUST00000045907.8
 2700049A03Rik

RIKEN cDNA 2700049A03 gene

chr8_+_69659263 0.263 ENSMUST00000169125.1
 Zfp964
zinc finger protein 964
chr6_+_145934113 0.196 ENSMUST00000032383.7
 Sspn
sarcospan
chr3_-_41742471 0.178 ENSMUST00000026866.8
 Sclt1
sodium channel and clathrin linker 1
chr4_+_94739276 0.161 ENSMUST00000073939.6
ENSMUST00000102798.1
 Tek

endothelial-specific receptor tyrosine kinase

chrX_+_101449078 0.100 ENSMUST00000033674.5
 Itgb1bp2
integrin beta 1 binding protein 2
chr7_+_101896817 0.075 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15
chr12_-_71136611 0.038 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr2_-_20943413 0.030 ENSMUST00000140230.1
 Arhgap21
Rho GTPase activating protein 21
chr2_-_160619971 0.002 ENSMUST00000109473.1
 Gm14221
predicted gene 14221

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.7 4.8 GO:0019532 oxalate transport(GO:0019532)
0.6 1.9 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.6 3.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 2.8 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.4 7.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 2.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.4 1.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) phosphate ion transmembrane transport(GO:0035435)
0.3 0.9 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 0.8 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 1.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.8 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 2.3 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 2.4 GO:0048305 immunoglobulin secretion(GO:0048305)
0.1 0.5 GO:0042701 progesterone secretion(GO:0042701)
0.1 1.5 GO:0051382 kinetochore assembly(GO:0051382)
0.1 1.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 6.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 3.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 1.4 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 2.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 1.2 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 1.3 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0044316 cone cell pedicle(GO:0044316)
0.4 1.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 2.3 GO:0071437 invadopodium(GO:0071437)
0.1 0.9 GO:0090543 Flemming body(GO:0090543)
0.1 1.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 2.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 10.7 GO:0030425 dendrite(GO:0030425)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 4.1 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.4 4.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 2.1 GO:0004359 glutaminase activity(GO:0004359)
0.3 7.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 2.8 GO:0005522 profilin binding(GO:0005522)
0.2 1.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.9 GO:0048038 quinone binding(GO:0048038)
0.1 3.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 2.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.2 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 1.7 GO:0043015 cAMP binding(GO:0030552) gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 1.9 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 9.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.9 GO:0017048 Rho GTPase binding(GO:0017048)