Motif ID: Mtf1

Z-value: 1.320


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.344.5e-03Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 80.991 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr8_+_94179089 51.902 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr11_-_32222233 23.224 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr11_+_63133068 16.367 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 15.244 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr1_+_135729147 14.685 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr17_+_85620816 9.919 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr1_-_169531343 8.595 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr14_-_26170283 8.121 ENSMUST00000100809.4
 Plac9b
placenta specific 9b
chr1_-_169531447 7.740 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_191906743 6.709 ENSMUST00000044954.6
 Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr1_+_131867224 6.693 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr6_-_39118211 6.664 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_+_119112793 6.429 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr1_+_157412352 6.017 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr7_+_119793987 5.507 ENSMUST00000033218.8
ENSMUST00000106520.1
 2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr12_+_24572276 5.399 ENSMUST00000085553.5
 Grhl1
grainyhead-like 1 (Drosophila)
chr7_+_119794102 5.241 ENSMUST00000084644.2
 2610020H08Rik
RIKEN cDNA 2610020H08 gene
chr5_-_125341043 4.750 ENSMUST00000111390.1
ENSMUST00000086075.6
 Scarb1

scavenger receptor class B, member 1

chr1_+_167618246 4.738 ENSMUST00000111380.1
 Rxrg
retinoid X receptor gamma
chr4_+_134496996 4.650 ENSMUST00000095074.3
 Paqr7
progestin and adipoQ receptor family member VII
chr9_-_14381242 4.607 ENSMUST00000167549.1
 Endod1
endonuclease domain containing 1
chr3_+_107895821 4.386 ENSMUST00000004134.4
 Gstm5
glutathione S-transferase, mu 5
chr3_+_107895916 4.320 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr4_+_129984833 4.176 ENSMUST00000120204.1
 Bai2
brain-specific angiogenesis inhibitor 2
chr13_+_23934434 3.951 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr1_-_166002613 3.875 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr6_+_145746739 3.760 ENSMUST00000111704.1
 Rassf8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr4_+_129985098 3.627 ENSMUST00000106017.1
ENSMUST00000121049.1
 Bai2

brain-specific angiogenesis inhibitor 2

chr1_-_166002591 3.583 ENSMUST00000111429.4
ENSMUST00000176800.1
 Pou2f1

POU domain, class 2, transcription factor 1

chr1_-_166309585 3.466 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr3_+_107896247 3.119 ENSMUST00000169365.1
 Gstm5
glutathione S-transferase, mu 5
chr17_+_71673255 2.981 ENSMUST00000097284.3
 Fam179a
family with sequence similarity 179, member A
chr8_-_54529951 2.880 ENSMUST00000067476.8
 Spcs3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr19_-_4839286 2.701 ENSMUST00000037246.5
 Ccs
copper chaperone for superoxide dismutase
chr10_+_70245083 2.649 ENSMUST00000046807.6
 Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr3_-_121815212 2.387 ENSMUST00000029770.5
 Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr8_+_13159135 2.332 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr7_+_132610620 2.211 ENSMUST00000033241.5
 Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr3_-_94412883 2.090 ENSMUST00000181305.1
 1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr19_-_4201591 2.014 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr7_-_119793958 1.938 ENSMUST00000106523.1
ENSMUST00000063902.7
ENSMUST00000150844.1
 Eri2


exoribonuclease 2


chr2_-_130664565 1.910 ENSMUST00000089559.4
 Ddrgk1
DDRGK domain containing 1
chr8_+_92827273 1.885 ENSMUST00000034187.7
 Mmp2
matrix metallopeptidase 2
chr12_+_103532435 1.868 ENSMUST00000021631.5
 Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr19_-_4615647 1.814 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr12_+_33957645 1.744 ENSMUST00000049089.5
 Twist1
twist basic helix-loop-helix transcription factor 1
chr5_+_105415738 1.631 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B
chr18_+_14424821 1.563 ENSMUST00000069552.5
 Gm5160
predicted gene 5160
chr19_-_4615453 1.439 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr10_+_77606217 1.353 ENSMUST00000129492.1
ENSMUST00000141228.2
 Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

chr1_+_75400070 1.170 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr5_+_115506668 1.105 ENSMUST00000067268.8
ENSMUST00000086523.3
 Pxn

paxillin

chr2_-_119787504 1.063 ENSMUST00000110793.1
ENSMUST00000099529.2
ENSMUST00000048493.5
 Rpap1


RNA polymerase II associated protein 1


chr18_-_84589491 1.007 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr2_+_31759932 0.984 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr5_-_99978914 0.972 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
 Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr2_+_29889720 0.959 ENSMUST00000113767.1
 Odf2
outer dense fiber of sperm tails 2
chr10_+_77606044 0.868 ENSMUST00000020501.8
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr13_-_45964964 0.792 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1


chr10_-_39899238 0.735 ENSMUST00000178563.1
 AA474331
expressed sequence AA474331
chr4_+_133574728 0.721 ENSMUST00000030662.2
 Gpatch3
G patch domain containing 3
chr17_-_56626872 0.609 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr9_+_109832998 0.581 ENSMUST00000119376.1
ENSMUST00000122343.1
 Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr2_+_150323702 0.547 ENSMUST00000133235.2
 Gm10130
predicted gene 10130
chr2_+_29889785 0.523 ENSMUST00000113763.1
ENSMUST00000113757.1
ENSMUST00000113756.1
ENSMUST00000133233.1
ENSMUST00000113759.2
ENSMUST00000113755.1
ENSMUST00000137558.1
ENSMUST00000046571.7
 Odf2







outer dense fiber of sperm tails 2







chr19_-_41263931 0.479 ENSMUST00000025989.8
 Tm9sf3
transmembrane 9 superfamily member 3
chr9_+_78175898 0.433 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr9_-_66124872 0.369 ENSMUST00000034946.8
 Snx1
sorting nexin 1
chr11_+_50131342 0.276 ENSMUST00000093138.6
ENSMUST00000101270.4
 Tbc1d9b

TBC1 domain family, member 9B

chr16_+_18348181 0.199 ENSMUST00000115614.2
ENSMUST00000115613.1
ENSMUST00000090103.3
 Arvcf


armadillo repeat gene deleted in velo-cardio-facial syndrome


chr10_+_77606571 0.189 ENSMUST00000099538.5
 Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr2_+_31759993 0.144 ENSMUST00000124089.1
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr2_-_173119402 0.018 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
19.0 132.9 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
6.7 6.7 GO:0061687 detoxification of inorganic compound(GO:0061687)
3.3 9.9 GO:0097402 neuroblast migration(GO:0097402)
1.8 31.6 GO:0032060 bleb assembly(GO:0032060)
1.7 11.8 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
1.6 6.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
1.6 4.7 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
1.1 7.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.9 5.4 GO:0002934 desmosome organization(GO:0002934)
0.8 2.4 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.8 2.3 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.6 1.7 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.5 16.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.5 1.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 1.1 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.4 23.2 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.3 1.0 GO:0045472 response to ether(GO:0045472)
0.3 1.9 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.3 2.6 GO:0046415 urate metabolic process(GO:0046415)
0.2 1.9 GO:0000467 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.2 14.7 GO:0070527 platelet aggregation(GO:0070527)
0.2 2.0 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 2.7 GO:0019430 removal of superoxide radicals(GO:0019430)
0.1 4.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 2.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.6 GO:0006183 GTP biosynthetic process(GO:0006183)
0.1 4.7 GO:0048477 oogenesis(GO:0048477)
0.1 1.1 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 4.0 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 1.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.2 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.6 GO:0098656 anion transmembrane transport(GO:0098656)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 16.3 GO:0031262 Ndc80 complex(GO:0031262)
1.3 31.6 GO:0043218 compact myelin(GO:0043218)
0.8 11.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.8 2.3 GO:0044194 cytolytic granule(GO:0044194)
0.6 6.4 GO:0000800 lateral element(GO:0000800)
0.3 2.0 GO:0030896 checkpoint clamp complex(GO:0030896)
0.3 4.7 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.4 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 49.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 1.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 2.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 6.7 GO:0030315 T-tubule(GO:0030315)
0.1 23.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.9 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 14.6 GO:0005925 focal adhesion(GO:0005925)
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0030880 RNA polymerase complex(GO:0030880)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.0 54.6 GO:0005507 copper ion binding(GO:0005507)
0.9 6.4 GO:0000150 recombinase activity(GO:0000150)
0.5 9.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.5 2.0 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.5 2.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 4.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.4 6.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 2.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.4 11.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.4 4.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.3 25.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 6.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 2.4 GO:0031386 protein tag(GO:0031386)
0.1 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.4 GO:1990460 leptin receptor binding(GO:1990460)
0.1 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.8 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.1 GO:0051400 BH domain binding(GO:0051400)
0.1 89.5 GO:0008270 zinc ion binding(GO:0008270)
0.1 2.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 5.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 4.6 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 1.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)