Motif ID: Mybl2

Z-value: 1.839


Transcription factors associated with Mybl2:

Gene SymbolEntrez IDGene Name
Mybl2 ENSMUSG00000017861.5 Mybl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl2mm10_v2_chr2_+_163054682_1630546930.914.0e-28Click!


Activity profile for motif Mybl2.

activity profile for motif Mybl2


Sorted Z-values histogram for motif Mybl2

Sorted Z-values for motif Mybl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_5591860 26.076 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr1_-_169531343 25.262 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_13573927 24.014 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr19_-_41802028 22.712 ENSMUST00000026150.8
ENSMUST00000177495.1
ENSMUST00000163265.1
 Arhgap19


Rho GTPase activating protein 19


chr1_-_169531447 20.818 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr13_+_51645232 19.111 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr14_-_67715585 18.879 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr1_+_191821444 18.555 ENSMUST00000027931.7
 Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr11_-_106999369 18.475 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr10_+_84838143 17.776 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr4_-_124936852 17.499 ENSMUST00000030690.5
ENSMUST00000084296.3
 Cdca8

cell division cycle associated 8

chr1_+_57995971 16.967 ENSMUST00000027202.8
 Sgol2
shugoshin-like 2 (S. pombe)
chr11_-_90002881 15.508 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr16_+_14163275 15.009 ENSMUST00000023359.6
ENSMUST00000117958.1
 Nde1

nuclear distribution gene E homolog 1 (A nidulans)

chr2_+_25372315 13.733 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr3_-_36571952 13.361 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr11_-_106999482 13.184 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr13_+_92354783 13.066 ENSMUST00000022218.4
 Dhfr
dihydrofolate reductase
chr9_+_65890237 12.834 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr7_-_30280335 12.691 ENSMUST00000108190.1
 Wdr62
WD repeat domain 62

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 38.8 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.1 27.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
2.9 26.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
4.8 24.0 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
1.9 22.8 GO:0019985 translesion synthesis(GO:0019985)
1.2 21.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
5.2 21.0 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.4 20.0 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
1.0 19.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
3.9 19.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.4 19.0 GO:0043486 histone exchange(GO:0043486)
0.6 18.2 GO:0007099 centriole replication(GO:0007099)
3.6 17.8 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.3 15.5 GO:0015914 phospholipid transport(GO:0015914)
1.4 15.0 GO:0007100 mitotic centrosome separation(GO:0007100)
1.4 15.0 GO:0070836 caveola assembly(GO:0070836)
0.3 13.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
3.3 13.1 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
2.1 12.5 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
1.8 12.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.4 56.4 GO:0031262 Ndc80 complex(GO:0031262)
0.4 53.0 GO:0000793 condensed chromosome(GO:0000793)
0.4 38.5 GO:0005643 nuclear pore(GO:0005643)
0.0 25.9 GO:0005615 extracellular space(GO:0005615)
6.0 24.0 GO:0045098 type III intermediate filament(GO:0045098)
0.4 21.9 GO:0005871 kinesin complex(GO:0005871)
0.1 21.7 GO:0005667 transcription factor complex(GO:0005667)
0.7 20.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.5 19.2 GO:0055038 recycling endosome membrane(GO:0055038)
3.5 17.5 GO:0032133 chromosome passenger complex(GO:0032133)
1.2 17.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 14.8 GO:0000922 spindle pole(GO:0000922)
2.0 14.1 GO:0001940 male pronucleus(GO:0001940)
1.0 13.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 10.9 GO:0005884 actin filament(GO:0005884)
1.7 10.0 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 9.8 GO:0005814 centriole(GO:0005814)
1.4 9.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 9.5 GO:0005876 spindle microtubule(GO:0005876)
3.0 9.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 29.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 26.1 GO:0070888 E-box binding(GO:0070888)
6.0 24.0 GO:1990254 keratin filament binding(GO:1990254)
0.1 23.7 GO:0042393 histone binding(GO:0042393)
0.3 21.9 GO:0003777 microtubule motor activity(GO:0003777)
0.5 20.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 20.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 17.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.6 15.5 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.9 15.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 14.1 GO:0019903 protein phosphatase binding(GO:0019903)
0.2 13.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 13.4 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
4.4 13.1 GO:0051870 methotrexate binding(GO:0051870)
0.8 12.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 11.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 11.2 GO:0008022 protein C-terminus binding(GO:0008022)
1.6 11.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
1.4 11.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 10.7 GO:0005080 protein kinase C binding(GO:0005080)