Motif ID: Nanog

Z-value: 0.799


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.362.5e-03Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_154960915 15.653 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr9_+_65890237 8.074 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr18_-_78206408 7.161 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr4_-_109665249 7.134 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr7_-_115846080 6.753 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chr15_-_71954395 6.351 ENSMUST00000159410.1
Col22a1
collagen, type XXII, alpha 1
chr3_+_88081997 6.270 ENSMUST00000071812.5
Iqgap3
IQ motif containing GTPase activating protein 3
chr19_-_36736653 5.665 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr7_+_67647405 5.582 ENSMUST00000032774.8
ENSMUST00000107471.1
Ttc23

tetratricopeptide repeat domain 23

chr10_+_58394381 5.563 ENSMUST00000105468.1
Lims1
LIM and senescent cell antigen-like domains 1
chr10_-_42583628 5.329 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr8_-_89044162 5.102 ENSMUST00000034090.6
Sall1
sal-like 1 (Drosophila)
chrX_+_134308084 4.975 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
Cenpi


centromere protein I


chr15_+_25773985 4.702 ENSMUST00000125667.1
Myo10
myosin X
chr10_+_58394361 4.650 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr5_+_33658123 4.489 ENSMUST00000074849.6
ENSMUST00000079534.4
Tacc3

transforming, acidic coiled-coil containing protein 3

chr5_+_33658567 4.377 ENSMUST00000114426.3
Tacc3
transforming, acidic coiled-coil containing protein 3
chr10_-_7212222 4.235 ENSMUST00000015346.5
Cnksr3
Cnksr family member 3
chr15_+_9436028 4.060 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr4_+_20008357 4.027 ENSMUST00000117632.1
ENSMUST00000098244.1
Ttpa

tocopherol (alpha) transfer protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 15.7 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.9 14.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.8 11.0 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
2.6 10.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.1 8.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.7 8.1 GO:0019985 translesion synthesis(GO:0019985)
1.0 7.2 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 7.1 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.0 6.8 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 5.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
1.1 5.3 GO:0021764 amygdala development(GO:0021764)
1.7 5.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 4.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 4.2 GO:0007067 mitotic nuclear division(GO:0007067)
1.0 4.0 GO:0042360 vitamin E metabolic process(GO:0042360)
0.8 4.0 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.4 4.0 GO:0014883 transition between fast and slow fiber(GO:0014883) positive regulation of stem cell population maintenance(GO:1902459)
0.3 3.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 3.9 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 3.8 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.1 GO:0005925 focal adhesion(GO:0005925)
0.0 12.1 GO:0005667 transcription factor complex(GO:0005667)
1.6 11.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 8.7 GO:0005815 microtubule organizing center(GO:0005815)
0.1 7.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 6.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.6 5.7 GO:0042587 glycogen granule(GO:0042587)
0.2 5.1 GO:0010369 chromocenter(GO:0010369)
0.1 4.7 GO:0016459 myosin complex(GO:0016459)
0.2 4.0 GO:0001891 phagocytic cup(GO:0001891)
0.2 3.9 GO:0002102 podosome(GO:0002102)
0.0 3.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 3.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 3.6 GO:0005770 late endosome(GO:0005770)
0.1 3.5 GO:0000788 nuclear nucleosome(GO:0000788)
1.0 3.1 GO:0000801 central element(GO:0000801)
0.0 3.0 GO:0000776 kinetochore(GO:0000776)
0.0 2.9 GO:0005814 centriole(GO:0005814)
0.5 2.6 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.1 2.5 GO:0001917 photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 12.8 GO:0003682 chromatin binding(GO:0003682)
0.5 11.1 GO:0051787 misfolded protein binding(GO:0051787)
0.2 8.1 GO:0004407 histone deacetylase activity(GO:0004407)
1.2 7.2 GO:0015265 urea channel activity(GO:0015265)
0.5 7.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.3 6.3 GO:0032027 myosin light chain binding(GO:0032027)
0.3 6.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 5.5 GO:0019901 protein kinase binding(GO:0019901)
0.0 5.2 GO:0042393 histone binding(GO:0042393)
0.0 5.2 GO:0003779 actin binding(GO:0003779)
0.0 4.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 4.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.4 4.3 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 4.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 4.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 3.2 GO:0030507 spectrin binding(GO:0030507)
0.4 2.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 2.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4 2.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)