Motif ID: Nfat5

Z-value: 0.717


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293463_1072934830.399.1e-04Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_97417730 5.723 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr6_-_101377897 4.876 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr6_+_120773633 4.539 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr6_-_58907120 4.290 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr4_-_82505749 4.207 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 4.197 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr5_-_104021919 3.527 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr7_+_99535652 3.503 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr1_+_24678536 3.388 ENSMUST00000095062.3
 Lmbrd1
LMBR1 domain containing 1
chr5_+_139423151 3.239 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr2_+_68117713 3.237 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr9_-_29963112 3.191 ENSMUST00000075069.4
 Ntm
neurotrimin
chr7_+_99535439 3.142 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr14_-_101609033 3.074 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr5_-_104021799 2.969 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr9_+_92457369 2.928 ENSMUST00000034941.7
 Plscr4
phospholipid scramblase 4
chr10_-_78352212 2.422 ENSMUST00000146899.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr4_-_138396438 2.367 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr10_+_21994666 2.202 ENSMUST00000020145.5
 Sgk1
serum/glucocorticoid regulated kinase 1
chr10_-_95415484 2.201 ENSMUST00000172070.1
ENSMUST00000150432.1
 Socs2

suppressor of cytokine signaling 2

chr19_-_5845471 2.185 ENSMUST00000174287.1
ENSMUST00000173672.1
 Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chr10_-_78352053 2.158 ENSMUST00000105388.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr10_-_78351690 2.151 ENSMUST00000166360.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr10_+_21993890 2.083 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr14_-_23803304 2.043 ENSMUST00000179836.1
ENSMUST00000172099.2
ENSMUST00000065788.8
ENSMUST00000179097.1
ENSMUST00000177634.1
ENSMUST00000074983.6
ENSMUST00000163322.2
ENSMUST00000100831.4
 Kcnma1







potassium large conductance calcium-activated channel, subfamily M, alpha member 1







chr15_-_98881255 2.031 ENSMUST00000024518.9
 Rhebl1
Ras homolog enriched in brain like 1
chr5_-_148392810 2.002 ENSMUST00000138257.1
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_-_78351711 1.893 ENSMUST00000105390.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr15_-_75894474 1.801 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chrX_-_155216338 1.761 ENSMUST00000112551.3
 Sat1
spermidine/spermine N1-acetyl transferase 1
chr7_+_110773658 1.737 ENSMUST00000143786.1
 Ampd3
adenosine monophosphate deaminase 3
chr8_-_107403197 1.709 ENSMUST00000003947.8
 Nqo1
NAD(P)H dehydrogenase, quinone 1
chr6_-_142964404 1.690 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr7_+_110774240 1.634 ENSMUST00000147587.1
 Ampd3
adenosine monophosphate deaminase 3
chr18_+_36559972 1.582 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chrX_-_155216444 1.502 ENSMUST00000026318.8
 Sat1
spermidine/spermine N1-acetyl transferase 1
chr16_-_55838827 1.391 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr7_-_80402743 1.377 ENSMUST00000122232.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr12_+_102948843 1.306 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr10_-_95415283 1.246 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2
chr14_-_55116935 1.236 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr3_-_129755305 1.235 ENSMUST00000029653.2
 Egf
epidermal growth factor
chr5_-_69592311 1.104 ENSMUST00000031117.6
 Gnpda2
glucosamine-6-phosphate deaminase 2
chr14_+_17660956 1.075 ENSMUST00000022303.7
ENSMUST00000091471.4
 Thrb

thyroid hormone receptor beta

chr11_+_102836296 1.069 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr10_-_62507737 1.050 ENSMUST00000020271.6
 Srgn
serglycin
chr1_+_83159733 1.048 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
 Daw1


dynein assembly factor with WDR repeat domains 1


chr8_-_46124146 1.047 ENSMUST00000170416.1
 Snx25
sorting nexin 25
chr10_+_84622365 1.003 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr3_-_27710413 0.974 ENSMUST00000046157.4
 Fndc3b
fibronectin type III domain containing 3B
chr18_+_36560581 0.907 ENSMUST00000155329.2
 Ankhd1
ankyrin repeat and KH domain containing 1
chr11_-_118401826 0.837 ENSMUST00000106290.3
ENSMUST00000043722.3
 Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr7_-_81493725 0.822 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr7_-_126625676 0.808 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chrX_+_123793665 0.794 ENSMUST00000178148.1
 Gm5167
predicted gene 5167
chr8_+_86745679 0.779 ENSMUST00000098532.2
 Gm10638
predicted gene 10638
chr4_+_110397764 0.713 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr12_-_86079019 0.710 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr7_+_6371364 0.693 ENSMUST00000086323.4
ENSMUST00000108559.2
 Zfp78

zinc finger protein 78

chr19_+_10525244 0.678 ENSMUST00000038379.3
 Cpsf7
cleavage and polyadenylation specific factor 7
chrX_+_74429671 0.651 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
 Ikbkg


inhibitor of kappaB kinase gamma


chr4_+_110397661 0.644 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr17_+_87107621 0.637 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr2_-_30415389 0.594 ENSMUST00000142096.1
 Crat
carnitine acetyltransferase
chr5_+_120511213 0.542 ENSMUST00000111890.2
ENSMUST00000076051.5
ENSMUST00000147496.1
 Slc8b1


solute carrier family 8 (sodium/lithium/calcium exchanger), member B1


chr19_-_10525201 0.508 ENSMUST00000025570.6
 Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr15_+_5185700 0.483 ENSMUST00000081640.5
 Ttc33
tetratricopeptide repeat domain 33
chrX_-_16817339 0.467 ENSMUST00000040820.6
 Maob
monoamine oxidase B
chr15_-_38078842 0.462 ENSMUST00000110336.2
 Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr5_+_120511168 0.440 ENSMUST00000068326.7
 Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr6_-_144209558 0.416 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr2_-_30415509 0.414 ENSMUST00000134120.1
ENSMUST00000102854.3
 Crat

carnitine acetyltransferase

chr11_-_88863717 0.414 ENSMUST00000107904.2
 Akap1
A kinase (PRKA) anchor protein 1
chr2_-_30415302 0.399 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr6_-_144209448 0.390 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr7_-_141918481 0.372 ENSMUST00000151890.1
 Tollip
toll interacting protein
chr17_+_43389436 0.345 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr5_+_90772435 0.311 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr2_+_125136692 0.304 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr6_-_144209471 0.289 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr7_-_46958475 0.273 ENSMUST00000094398.4
 Uevld
UEV and lactate/malate dehyrogenase domains
chr19_+_25236959 0.272 ENSMUST00000049400.8
 Kank1
KN motif and ankyrin repeat domains 1
chr5_-_66618772 0.251 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
 Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr3_-_69004565 0.221 ENSMUST00000169064.1
 Ift80
intraflagellar transport 80
chr9_-_7835255 0.196 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr7_-_81493883 0.178 ENSMUST00000082090.7
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr6_+_91684061 0.138 ENSMUST00000032185.7
 Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr18_-_43477764 0.137 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chrX_-_49797700 0.089 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr9_-_71771535 0.023 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
 Cgnl1


cingulin-like 1


chrX_+_139684980 0.002 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr10_-_7663569 0.000 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.1 3.3 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
1.1 3.2 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.9 6.6 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.6 6.5 GO:0042447 hormone catabolic process(GO:0042447)
0.5 2.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.4 3.4 GO:0032264 IMP salvage(GO:0032264)
0.4 1.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 1.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.3 3.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 1.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 2.0 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.3 4.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 1.4 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 1.2 GO:0007262 STAT protein import into nucleus(GO:0007262) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.2 0.7 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.2 3.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 1.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 5.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.2 3.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.2 1.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.2 1.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 0.5 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.2 0.5 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.0 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.1 1.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 2.2 GO:0030575 nuclear body organization(GO:0030575)
0.1 0.6 GO:0071638 positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 0.2 GO:1900044 regulation of protein K63-linked ubiquitination(GO:1900044)
0.1 4.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.8 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 2.1 GO:0046325 negative regulation of glucose import(GO:0046325)
0.1 1.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.1 1.0 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 0.5 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 1.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 8.6 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 1.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 4.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.7 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 2.0 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.4 GO:0036010 protein localization to endosome(GO:0036010)
0.0 2.5 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 1.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.6 GO:0031143 pseudopodium(GO:0031143)
0.4 8.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 2.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.3 3.2 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.3 2.2 GO:0042382 paraspeckles(GO:0042382)
0.2 1.2 GO:0030314 junctional membrane complex(GO:0030314)
0.1 3.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 1.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 6.9 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:1904115 axon cytoplasm(GO:1904115)
0.1 1.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 4.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.3 GO:0031091 platelet alpha granule(GO:0031091)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 2.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.8 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.1 3.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.9 6.5 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.7 3.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.7 2.0 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.5 4.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.5 3.4 GO:0031419 cobalamin binding(GO:0031419)
0.5 3.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 1.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 8.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 3.2 GO:1990239 steroid hormone binding(GO:1990239)
0.4 3.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.4 2.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.4 1.4 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.3 2.0 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.3 1.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.0 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 8.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 0.7 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.2 1.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.0 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.1 1.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.0 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 4.6 GO:0015293 symporter activity(GO:0015293)
0.0 0.4 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 4.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)