Motif ID: Nfatc1

Z-value: 4.670


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80708115_807081800.019.2e-01Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 207.304 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 205.792 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 187.955 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 184.612 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 181.043 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3037111 170.002 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 158.375 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3025417 157.949 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3017408 153.977 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3034599 153.636 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3005125 149.753 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr14_-_19418930 132.245 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 129.043 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr2_-_98667264 127.268 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3018753 113.901 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 99.776 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr10_+_4611971 18.291 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr3_-_145649970 17.040 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr7_+_134670667 14.342 ENSMUST00000084488.4
 Dock1
dedicator of cytokinesis 1
chr11_+_112782182 13.780 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1051.4 GO:0008150 biological_process(GO:0008150)
2.9 20.6 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
2.8 19.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
6.1 18.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
6.0 18.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
5.7 17.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
4.6 13.8 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
3.4 13.4 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
3.1 12.6 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.4 12.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.0 11.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
1.2 10.9 GO:0035881 amacrine cell differentiation(GO:0035881)
0.6 10.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 10.6 GO:0000910 cytokinesis(GO:0000910)
0.5 9.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.6 9.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
3.1 9.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.3 9.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
2.9 8.7 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
2.9 8.6 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1283.1 GO:0005575 cellular_component(GO:0005575)
0.1 38.3 GO:0005667 transcription factor complex(GO:0005667)
1.6 14.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.8 14.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
3.4 13.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 10.6 GO:0030496 midbody(GO:0030496)
1.1 10.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.9 8.6 GO:0071914 prominosome(GO:0071914)
0.2 8.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 7.7 GO:0005614 interstitial matrix(GO:0005614)
0.2 7.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 7.2 GO:0005581 collagen trimer(GO:0005581)
1.0 6.2 GO:0045179 apical cortex(GO:0045179)
0.4 5.8 GO:0036038 MKS complex(GO:0036038)
0.1 5.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 5.3 GO:0001527 microfibril(GO:0001527)
0.7 5.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 5.0 GO:0097449 astrocyte projection(GO:0097449)
0.3 3.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 3.1 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1170.7 GO:0003674 molecular_function(GO:0003674)
0.2 23.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
5.1 20.6 GO:0008142 oxysterol binding(GO:0008142)
0.6 19.8 GO:0042805 actinin binding(GO:0042805)
0.9 18.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
6.1 18.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 15.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.3 14.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
2.7 13.4 GO:0005113 patched binding(GO:0005113)
2.5 12.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
2.8 11.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 10.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 8.7 GO:0030332 cyclin binding(GO:0030332)
2.6 7.8 GO:0005534 galactose binding(GO:0005534)
0.5 7.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.5 7.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 6.1 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.8 5.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.7 5.3 GO:0042609 CD4 receptor binding(GO:0042609)
1.7 5.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)