Motif ID: Nfatc2

Z-value: 1.273


Transcription factors associated with Nfatc2:

Gene SymbolEntrez IDGene Name
Nfatc2 ENSMUSG00000027544.10 Nfatc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc2mm10_v2_chr2_-_168601620_1686016570.244.2e-02Click!


Activity profile for motif Nfatc2.

activity profile for motif Nfatc2


Sorted Z-values histogram for motif Nfatc2

Sorted Z-values for motif Nfatc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 21.481 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_+_3000922 8.684 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 8.208 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 7.528 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3013140 7.438 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 7.380 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr12_+_29528382 7.377 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr9_+_3037111 7.106 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3017408 6.795 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3036877 6.620 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr14_+_75955003 6.412 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chrX_-_143933089 6.409 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_98662227 6.272 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr9_+_3034599 6.239 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr2_-_98667264 6.107 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3025417 6.006 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr17_-_91088726 5.946 ENSMUST00000072671.7
ENSMUST00000174331.1
ENSMUST00000161402.3
ENSMUST00000054059.8
 Nrxn1



neurexin I



chr9_+_3005125 5.938 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr11_+_31872100 5.834 ENSMUST00000020543.6
ENSMUST00000109412.2
 Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr9_+_3015654 5.784 ENSMUST00000099050.3
 Gm10720
predicted gene 10720

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 284 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 12.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.6 10.9 GO:0021860 pyramidal neuron development(GO:0021860)
2.4 9.7 GO:0035063 nuclear speck organization(GO:0035063)
0.3 9.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.2 9.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 7.3 GO:0072661 protein targeting to plasma membrane(GO:0072661)
1.2 5.9 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.5 5.3 GO:0048149 behavioral response to ethanol(GO:0048149)
1.0 5.2 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.7 5.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.5 5.1 GO:0042118 endothelial cell activation(GO:0042118)
0.4 4.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 4.5 GO:0007097 nuclear migration(GO:0007097)
0.2 4.5 GO:0097320 membrane tubulation(GO:0097320)
0.1 4.5 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.8 4.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.7 4.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.6 4.2 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.6 4.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.4 GO:0060076 excitatory synapse(GO:0060076)
0.1 14.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 9.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 9.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 7.9 GO:0071565 nBAF complex(GO:0071565)
0.0 7.4 GO:0005874 microtubule(GO:0005874)
0.1 7.2 GO:0016607 nuclear speck(GO:0016607)
0.1 6.6 GO:0043197 dendritic spine(GO:0043197)
0.1 6.5 GO:0043198 dendritic shaft(GO:0043198)
0.4 6.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 6.3 GO:0042734 presynaptic membrane(GO:0042734)
0.2 6.2 GO:0043194 axon initial segment(GO:0043194)
0.2 6.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 5.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 5.4 GO:0043034 costamere(GO:0043034)
0.4 5.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 4.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 4.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 4.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 3.4 GO:0005677 chromatin silencing complex(GO:0005677)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 GO:0008017 microtubule binding(GO:0008017)
0.5 11.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 7.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 7.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.6 6.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 6.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 5.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 5.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.9 5.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.1 5.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 5.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.3 5.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 5.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 5.1 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.3 5.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.6 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 4.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 4.3 GO:0042043 neurexin family protein binding(GO:0042043)
1.0 4.2 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 4.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)