Motif ID: Nfatc3

Z-value: 1.110


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_1060596230.272.2e-02Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_80713062 12.092 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr17_-_49564262 10.014 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr19_+_58670358 7.876 ENSMUST00000057270.7
 Pnlip
pancreatic lipase
chr3_-_145649970 7.752 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr15_-_79164477 7.387 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr11_+_63133068 7.196 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr1_-_162866502 7.145 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr4_-_97584605 6.555 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 6.104 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_+_12718496 6.054 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr11_+_63132569 5.784 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr17_-_70849644 5.564 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr1_-_170110491 5.538 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr10_+_4611971 5.098 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr1_-_66863265 5.072 ENSMUST00000027153.5
 Acadl
acyl-Coenzyme A dehydrogenase, long-chain
chr6_+_48841476 4.969 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr4_-_43523595 4.664 ENSMUST00000107914.3
 Tpm2
tropomyosin 2, beta
chr6_+_48841633 4.659 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr16_+_30065333 4.570 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr6_+_120773633 4.547 ENSMUST00000112682.2
 Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.7 13.0 GO:0032060 bleb assembly(GO:0032060)
4.0 12.1 GO:0060854 patterning of lymph vessels(GO:0060854)
0.1 9.6 GO:0007368 determination of left/right symmetry(GO:0007368)
3.0 9.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
1.3 7.9 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.5 7.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.6 7.4 GO:0032808 lacrimal gland development(GO:0032808) enteric nervous system development(GO:0048484)
2.4 7.3 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.7 7.1 GO:0009404 toxin metabolic process(GO:0009404)
0.4 6.4 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
1.5 6.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.2 6.0 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.9 5.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
1.3 5.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 5.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.5 4.9 GO:0070836 caveola assembly(GO:0070836)
1.6 4.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.5 4.6 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 4.5 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 13.3 GO:0000790 nuclear chromatin(GO:0000790)
0.5 13.0 GO:0043218 compact myelin(GO:0043218)
0.0 11.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.9 8.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.9 7.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 5.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 5.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 4.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 4.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.2 GO:0016459 myosin complex(GO:0016459)
0.0 4.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.7 GO:0032432 actin filament bundle(GO:0032432)
0.4 3.6 GO:0030478 actin cap(GO:0030478)
0.1 3.4 GO:0097440 apical dendrite(GO:0097440)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 3.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 2.8 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 12.1 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224)
0.4 10.9 GO:0008432 JUN kinase binding(GO:0008432)
0.1 10.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.4 9.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 8.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 7.9 GO:0004806 triglyceride lipase activity(GO:0004806)
2.4 7.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
1.4 7.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 7.1 GO:0017048 Rho GTPase binding(GO:0017048)
1.2 6.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 6.1 GO:0051015 actin filament binding(GO:0051015)
0.2 5.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.6 5.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.7 5.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.8 5.1 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 4.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 4.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 4.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)