Motif ID: Nfatc4

Z-value: 0.577


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.807.7e-17Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Showing 1 to 20 of 58 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56978534 10.005 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr13_+_83504032 8.059 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr19_+_26623419 6.982 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_48049080 6.730 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_56969864 6.512 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_-_4943049 5.724 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr11_+_97415527 4.431 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr2_+_55435918 4.108 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr5_+_117363513 3.630 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr19_-_8839181 3.107 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr1_-_126830632 2.934 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr2_+_125136692 2.929 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr13_-_52981027 2.826 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr2_-_66410064 2.687 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr14_+_70555900 2.638 ENSMUST00000163060.1
 Hr
hairless
chr1_-_193370225 2.633 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 2.555 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr11_+_29692937 2.339 ENSMUST00000102843.3
ENSMUST00000102842.3
ENSMUST00000078830.4
ENSMUST00000170731.1
 Rtn4



reticulon 4



chr9_+_113812547 2.301 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr15_+_92051153 2.198 ENSMUST00000169825.1
 Cntn1
contactin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.7 8.1 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.8 7.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
2.2 6.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.9 5.7 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.0 4.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 4.1 GO:0010107 potassium ion import(GO:0010107)
0.1 2.8 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.3 2.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 2.6 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.4 GO:0048813 dendrite morphogenesis(GO:0048813)
0.5 2.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 2.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 2.0 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.6 1.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.1 1.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 1.8 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.3 1.5 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 1.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 1.5 GO:0008045 motor neuron axon guidance(GO:0008045)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 8.1 GO:0016607 nuclear speck(GO:0016607)
0.4 7.0 GO:0071564 npBAF complex(GO:0071564)
0.0 3.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 2.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 2.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 2.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.5 1.9 GO:0031673 H zone(GO:0031673)
0.0 1.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 0.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.1 GO:0003680 AT DNA binding(GO:0003680)
0.1 7.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 5.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 5.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 4.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.8 4.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 3.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 3.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 2.7 GO:0031402 sodium ion binding(GO:0031402)
0.2 2.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 2.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 2.2 GO:0001948 glycoprotein binding(GO:0001948)
0.4 2.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.2 1.9 GO:0008301 DNA binding, bending(GO:0008301)
0.2 1.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)