Motif ID: Nfatc4

Z-value: 0.577


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.807.7e-17Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56978534 10.005 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr13_+_83504032 8.059 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr19_+_26623419 6.982 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_48049080 6.730 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_56969864 6.512 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_-_4943049 5.724 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr11_+_97415527 4.431 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr2_+_55435918 4.108 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr5_+_117363513 3.630 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr19_-_8839181 3.107 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr1_-_126830632 2.934 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr2_+_125136692 2.929 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr13_-_52981027 2.826 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr2_-_66410064 2.687 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr14_+_70555900 2.638 ENSMUST00000163060.1
 Hr
hairless
chr1_-_193370225 2.633 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 2.555 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr11_+_29692937 2.339 ENSMUST00000102843.3
ENSMUST00000102842.3
ENSMUST00000078830.4
ENSMUST00000170731.1
 Rtn4



reticulon 4



chr9_+_113812547 2.301 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr15_+_92051153 2.198 ENSMUST00000169825.1
 Cntn1
contactin 1
chrX_+_7638674 2.150 ENSMUST00000128890.1
 Syp
synaptophysin
chr6_-_59024470 2.146 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr3_-_37125943 1.975 ENSMUST00000029275.5
 Il2
interleukin 2
chr13_+_31806627 1.939 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr1_+_34005872 1.939 ENSMUST00000182296.1
 Dst
dystonin
chr6_-_59024340 1.747 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr10_+_21993890 1.513 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr18_-_62741387 1.500 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr2_-_73660351 1.452 ENSMUST00000154258.1
 Chn1
chimerin (chimaerin) 1
chr19_+_8839298 1.325 ENSMUST00000160556.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr8_-_64205970 1.323 ENSMUST00000066166.4
 Tll1
tolloid-like
chr12_+_76533540 1.313 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_-_64121456 1.294 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr1_-_126830786 1.249 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr1_-_64121389 1.079 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr15_-_79062866 0.936 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr3_+_94837533 0.872 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr8_-_41041828 0.813 ENSMUST00000051379.7
 Mtus1
mitochondrial tumor suppressor 1
chr12_-_84450944 0.809 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr3_+_84925476 0.807 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr11_+_75468040 0.804 ENSMUST00000043598.7
ENSMUST00000108435.1
 Tlcd2

TLC domain containing 2

chrX_+_48623737 0.776 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr9_-_13446753 0.643 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr19_+_29101375 0.576 ENSMUST00000064393.5
 Rcl1
RNA terminal phosphate cyclase-like 1
chr7_-_79920599 0.573 ENSMUST00000075657.6
 Ap3s2
adaptor-related protein complex 3, sigma 2 subunit
chr7_-_4778141 0.501 ENSMUST00000094892.5
 Il11
interleukin 11
chr12_+_84451485 0.431 ENSMUST00000137170.1
 Lin52
lin-52 homolog (C. elegans)
chr3_-_152193803 0.431 ENSMUST00000050073.6
 Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr11_-_35980473 0.323 ENSMUST00000018993.6
 Wwc1
WW, C2 and coiled-coil domain containing 1
chr3_-_96594128 0.320 ENSMUST00000145001.1
ENSMUST00000091924.3
 Polr3gl

polymerase (RNA) III (DNA directed) polypeptide G like

chr2_-_165884636 0.294 ENSMUST00000177633.1
ENSMUST00000018050.7
ENSMUST00000088113.4
 Zmynd8


zinc finger, MYND-type containing 8


chr19_+_8850785 0.256 ENSMUST00000096257.2
 Lrrn4cl
LRRN4 C-terminal like
chr14_+_47663756 0.196 ENSMUST00000022391.7
 Ktn1
kinectin 1
chr16_+_43364145 0.195 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr2_-_116067391 0.130 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr15_+_3270767 0.118 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr4_+_130107556 0.107 ENSMUST00000030563.5
 Pef1
penta-EF hand domain containing 1
chr15_-_79932516 0.101 ENSMUST00000177044.1
ENSMUST00000109615.1
ENSMUST00000089293.4
ENSMUST00000109616.2
 Cbx7



chromobox 7




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.2 6.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.9 5.7 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.0 16.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 7.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 1.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.5 2.0 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.5 2.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 1.2 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.4 2.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 1.5 GO:0060467 negative regulation of fertilization(GO:0060467)
0.3 0.8 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 2.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.8 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 4.1 GO:0010107 potassium ion import(GO:0010107)
0.1 1.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.6 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 1.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 2.8 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 1.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.9 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897) regulation of dendritic spine maintenance(GO:1902950) positive regulation of dendritic spine maintenance(GO:1902952)
0.0 0.8 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.9 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 1.5 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.8 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 4.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 2.6 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.4 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 1.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.5 1.9 GO:0031673 H zone(GO:0031673)
0.4 7.0 GO:0071564 npBAF complex(GO:0071564)
0.2 2.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 0.8 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 19.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 8.1 GO:0016607 nuclear speck(GO:0016607)
0.1 0.6 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 3.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.7 8.1 GO:0003680 AT DNA binding(GO:0003680)
0.4 2.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.3 4.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 3.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.2 0.6 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.2 1.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 1.9 GO:0008301 DNA binding, bending(GO:0008301)
0.2 2.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 0.8 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 2.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.7 GO:0031402 sodium ion binding(GO:0031402)
0.1 5.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 7.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 5.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.2 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0008083 growth factor activity(GO:0008083)
0.0 3.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)