Motif ID: Nfe2_Bach1_Mafk

Z-value: 1.072

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafkmm10_v2_chr5_+_139791513_1397915390.651.2e-09Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.551.1e-06Click!
Bach1mm10_v2_chr16_+_87698904_876989590.441.6e-04Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 31.480 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 23.793 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr2_+_136713444 11.344 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr2_+_155775333 9.666 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr3_+_123267445 9.440 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr6_+_5725812 8.275 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chrX_-_103186618 7.932 ENSMUST00000121720.1
 Nap1l2
nucleosome assembly protein 1-like 2
chr13_-_54611274 7.534 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr13_-_54611332 7.001 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr5_-_139484475 6.887 ENSMUST00000110851.1
ENSMUST00000079996.6
 Zfand2a

zinc finger, AN1-type domain 2A

chr5_-_139484420 6.565 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A
chr17_-_56133817 6.439 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr2_+_156475803 5.859 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr19_-_8839181 5.762 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr6_-_13838432 5.705 ENSMUST00000115492.1
 Gpr85
G protein-coupled receptor 85
chr2_+_156475844 5.565 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_118663235 5.511 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr12_+_111758923 5.039 ENSMUST00000118471.1
ENSMUST00000122300.1
 Klc1

kinesin light chain 1

chr16_+_17561885 4.944 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr3_+_146852359 4.894 ENSMUST00000038090.5
ENSMUST00000170055.1
 Ttll7

tubulin tyrosine ligase-like family, member 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 39.0 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.6 23.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.4 13.5 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.2 13.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.7 11.3 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
2.3 9.1 GO:0035617 stress granule disassembly(GO:0035617)
1.0 8.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
1.5 8.7 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1 8.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.9 8.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.8 6.5 GO:0005513 detection of calcium ion(GO:0005513)
0.2 6.4 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 5.5 GO:0007612 learning(GO:0007612)
0.4 5.4 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 5.4 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.6 5.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 5.2 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.1 5.0 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.5 4.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 4.9 GO:0033198 response to ATP(GO:0033198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 39.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
1.4 15.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.5 13.2 GO:0071565 nBAF complex(GO:0071565)
2.8 11.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.2 10.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 10.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 10.0 GO:0005604 basement membrane(GO:0005604)
0.3 9.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 9.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 8.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 7.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 6.5 GO:0000502 proteasome complex(GO:0000502)
0.0 5.7 GO:0043197 dendritic spine(GO:0043197)
0.0 5.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 5.5 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
1.6 4.9 GO:0036501 UFD1-NPL4 complex(GO:0036501)
0.4 4.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 4.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 4.8 GO:0009925 basal plasma membrane(GO:0009925)
0.9 4.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.0 39.8 GO:0045503 dynein light chain binding(GO:0045503)
0.7 23.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.6 14.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 13.9 GO:0003777 microtubule motor activity(GO:0003777)
0.5 11.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 9.7 GO:0045296 cadherin binding(GO:0045296)
0.1 9.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 9.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 8.7 GO:0005518 collagen binding(GO:0005518)
0.1 8.1 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 7.9 GO:0042393 histone binding(GO:0042393)
2.0 7.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 7.0 GO:0008017 microtubule binding(GO:0008017)
0.2 6.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 6.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.4 6.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 6.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 6.0 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 5.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)