Motif ID: Nfia

Z-value: 2.023


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97777606_977776320.423.3e-04Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 36.087 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr6_+_141524379 31.167 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr7_+_130936172 29.535 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr11_-_102897123 23.470 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr11_-_102897146 23.023 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr18_+_20665250 21.779 ENSMUST00000075312.3
 Ttr
transthyretin
chr19_+_5740885 20.364 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr7_-_97417730 20.282 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_-_64046925 19.906 ENSMUST00000107377.3
 Tnc
tenascin C
chr6_-_115251839 17.790 ENSMUST00000032462.6
 Timp4
tissue inhibitor of metalloproteinase 4
chr16_+_91269759 17.748 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr3_-_116129615 17.315 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr12_+_85473883 14.883 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr10_+_57784859 14.637 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr9_-_54661870 13.213 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chrX_+_100729917 13.185 ENSMUST00000019503.7
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr3_-_90514250 13.014 ENSMUST00000107340.1
ENSMUST00000060738.8
 S100a1

S100 calcium binding protein A1

chr10_+_127725392 12.672 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr6_+_90465287 12.638 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr6_-_53820764 12.617 ENSMUST00000127748.2
 Tril
TLR4 interactor with leucine-rich repeats

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 333 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.7 46.5 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
3.6 36.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
4.9 29.5 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
2.8 27.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
2.5 25.1 GO:0090527 actin filament reorganization(GO:0090527)
4.8 24.0 GO:0070327 thyroid hormone transport(GO:0070327)
6.8 20.4 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
6.6 19.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
3.9 19.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.5 19.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.7 18.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.7 18.2 GO:0046039 GTP metabolic process(GO:0046039)
1.6 18.1 GO:0035584 calcium-mediated signaling using intracellular calcium source(GO:0035584)
3.6 17.9 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
5.5 16.4 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
2.4 14.6 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.9 14.6 GO:0060134 prepulse inhibition(GO:0060134)
0.4 14.3 GO:0070206 protein trimerization(GO:0070206)
2.7 13.4 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.6 13.1 GO:0033622 integrin activation(GO:0033622)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 108.6 GO:0031012 extracellular matrix(GO:0031012)
11.6 46.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 43.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 42.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 41.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 35.4 GO:0070062 extracellular exosome(GO:0070062)
0.2 27.0 GO:0005884 actin filament(GO:0005884)
1.5 23.8 GO:0005614 interstitial matrix(GO:0005614)
0.2 18.3 GO:0031225 anchored component of membrane(GO:0031225)
0.3 17.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 17.1 GO:0000786 nucleosome(GO:0000786)
0.1 16.2 GO:0005911 cell-cell junction(GO:0005911)
2.1 14.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.6 14.6 GO:0002102 podosome(GO:0002102)
0.2 14.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 14.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.7 13.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 12.7 GO:0005901 caveola(GO:0005901)
2.1 12.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.8 12.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 231 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 64.2 GO:0005178 integrin binding(GO:0005178)
6.0 36.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
7.8 31.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.3 29.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
2.5 24.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
3.0 24.0 GO:0070324 thyroid hormone binding(GO:0070324)
2.1 23.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 21.8 GO:0070412 R-SMAD binding(GO:0070412)
0.9 21.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
3.3 19.9 GO:0045545 syndecan binding(GO:0045545)
4.9 19.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.4 17.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
4.3 17.3 GO:0008131 primary amine oxidase activity(GO:0008131)
5.5 16.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.3 15.4 GO:0019003 GDP binding(GO:0019003)
2.5 15.1 GO:0030284 estrogen receptor activity(GO:0030284)
1.1 14.8 GO:0005522 profilin binding(GO:0005522)
0.2 14.7 GO:0005080 protein kinase C binding(GO:0005080)
0.7 14.0 GO:0051787 misfolded protein binding(GO:0051787)
4.6 13.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)