Motif ID: Nfix

Z-value: 1.125


Transcription factors associated with Nfix:

Gene SymbolEntrez IDGene Name
Nfix ENSMUSG00000001911.10 Nfix

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfixmm10_v2_chr8_-_84800344_848003780.665.9e-10Click!


Activity profile for motif Nfix.

activity profile for motif Nfix


Sorted Z-values histogram for motif Nfix

Sorted Z-values for motif Nfix



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfix

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 32.019 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr10_+_57784859 23.269 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr10_+_57784914 20.146 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr7_-_97417730 17.969 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr11_+_3488275 13.282 ENSMUST00000064265.6
 Pla2g3
phospholipase A2, group III
chr16_+_41532851 11.530 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr11_-_102897123 11.157 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr16_+_42907563 10.144 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr17_-_49564262 9.636 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr7_+_130936172 9.482 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr1_+_169929929 8.619 ENSMUST00000175731.1
 1700084C01Rik
RIKEN cDNA 1700084C01 gene
chr6_+_135362931 8.512 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr15_-_88978958 8.188 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr11_-_102897146 7.836 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr18_-_78123324 7.743 ENSMUST00000160292.1
ENSMUST00000091813.5
 Slc14a1

solute carrier family 14 (urea transporter), member 1

chr1_-_172219715 7.736 ENSMUST00000170700.1
ENSMUST00000003554.4
 Casq1

calsequestrin 1

chrX_-_57338598 7.628 ENSMUST00000033468.4
ENSMUST00000114736.1
 Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr5_+_66745835 7.329 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr5_-_77115145 7.212 ENSMUST00000081964.5
 Hopx
HOP homeobox
chr11_+_63128973 7.175 ENSMUST00000108702.1
 Pmp22
peripheral myelin protein 22

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 43.4 GO:0060134 prepulse inhibition(GO:0060134)
3.2 32.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.7 19.2 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
3.2 19.0 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.9 15.7 GO:0032060 bleb assembly(GO:0032060)
3.3 13.3 GO:0019372 lipoxygenase pathway(GO:0019372)
0.3 12.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 11.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 11.3 GO:0031032 actomyosin structure organization(GO:0031032)
1.6 9.5 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.6 8.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
1.6 8.2 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 8.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.6 7.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
2.6 7.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.3 7.7 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 7.3 GO:0030032 lamellipodium assembly(GO:0030032)
1.2 7.2 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.5 6.6 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.2 6.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 58.1 GO:0005911 cell-cell junction(GO:0005911)
0.1 48.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 21.7 GO:0031225 anchored component of membrane(GO:0031225)
4.7 19.0 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 16.2 GO:0031012 extracellular matrix(GO:0031012)
0.1 13.9 GO:0005814 centriole(GO:0005814)
0.4 8.4 GO:0000930 gamma-tubulin complex(GO:0000930)
2.6 7.7 GO:0014802 terminal cisterna(GO:0014802)
0.0 7.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 7.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 7.2 GO:0043218 compact myelin(GO:0043218)
0.1 4.6 GO:0032420 stereocilium(GO:0032420)
0.2 4.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.9 4.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.0 4.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.6 GO:0031430 M band(GO:0031430)
0.2 3.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 3.1 GO:0097433 dense body(GO:0097433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 41.7 GO:0005504 fatty acid binding(GO:0005504)
8.0 32.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 18.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 13.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 11.2 GO:0008270 zinc ion binding(GO:0008270)
0.5 9.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 9.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 9.3 GO:0008565 protein transporter activity(GO:0008565)
0.1 8.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 8.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.6 7.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.3 7.7 GO:0015265 urea channel activity(GO:0015265)
0.1 7.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.1 6.4 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
1.0 5.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 5.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 4.8 GO:0001223 transcription coactivator binding(GO:0001223)
1.1 4.6 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.7 4.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.0 4.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)