Motif ID: Nfkb2

Z-value: 0.536


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46305682_46305741-0.291.5e-02Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_29289300 4.729 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_74791516 4.631 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr19_+_7268296 3.181 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chrX_+_163908982 2.582 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_167001417 2.420 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B
chr13_-_111490111 2.335 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr2_-_37422869 2.181 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr13_-_111490028 2.160 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr2_+_172550991 2.081 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chrX_+_163909132 1.973 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr2_+_172550761 1.940 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr1_+_153740344 1.658 ENSMUST00000027748.7
 Rgs16
regulator of G-protein signaling 16
chr14_-_30607808 1.593 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr1_+_167001457 1.492 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr1_-_66817536 1.463 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_+_101176041 1.404 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr11_-_54962903 1.355 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr14_-_30626196 1.271 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr4_-_125127817 1.266 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr5_+_37245792 1.176 ENSMUST00000031004.7
 Crmp1
collapsin response mediator protein 1
chr11_-_84870712 1.079 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr3_-_116424007 0.991 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 0.970 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr11_-_84870812 0.938 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr11_-_84870646 0.909 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr18_-_77565050 0.904 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
 Rnf165



ring finger protein 165



chr10_+_80702649 0.871 ENSMUST00000095426.3
 Izumo4
IZUMO family member 4
chr14_+_80000292 0.804 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr19_+_6341121 0.791 ENSMUST00000025897.6
ENSMUST00000130382.1
 Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr1_-_63114255 0.762 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr5_+_90759299 0.718 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr14_-_55591077 0.656 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr11_-_70656467 0.654 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr1_-_63114516 0.630 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr11_+_70029742 0.628 ENSMUST00000132597.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr11_-_70015346 0.616 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr17_+_35866606 0.532 ENSMUST00000113814.4
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr8_+_79028317 0.532 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr11_+_77686155 0.514 ENSMUST00000100802.4
ENSMUST00000181023.1
 Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr11_-_84870188 0.490 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr1_+_135132693 0.474 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr7_-_34654342 0.464 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr10_-_89686250 0.442 ENSMUST00000092227.5
ENSMUST00000174252.1
 Scyl2

SCY1-like 2 (S. cerevisiae)

chr4_+_100776664 0.429 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr11_+_70657687 0.420 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr1_+_135133272 0.395 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr9_+_55326913 0.368 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr8_+_108714644 0.352 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr5_+_110544326 0.345 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr5_+_90891234 0.344 ENSMUST00000031327.8
 Cxcl1
chemokine (C-X-C motif) ligand 1
chr3_+_97658212 0.338 ENSMUST00000045743.6
 Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr17_+_35379608 0.337 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr8_-_105289465 0.320 ENSMUST00000171788.1
ENSMUST00000014981.6
 4931428F04Rik

RIKEN cDNA 4931428F04 gene

chr19_+_45015198 0.319 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr11_+_70657196 0.300 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr7_+_19176416 0.286 ENSMUST00000117338.1
 Eml2
echinoderm microtubule associated protein like 2
chr16_+_32914094 0.285 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr2_-_32312162 0.283 ENSMUST00000155269.1
 Dnm1
dynamin 1
chr17_+_35866056 0.261 ENSMUST00000122899.1
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr15_-_76918010 0.223 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr14_+_55591708 0.182 ENSMUST00000019443.8
 Rnf31
ring finger protein 31
chr1_-_5019342 0.172 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20
chr7_+_16309577 0.165 ENSMUST00000002152.6
 Bbc3
BCL2 binding component 3
chr5_-_137530990 0.154 ENSMUST00000132525.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr5_-_137531204 0.133 ENSMUST00000150063.2
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr5_+_135887988 0.122 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr17_+_35424842 0.101 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr4_-_133339238 0.093 ENSMUST00000105906.1
 Wdtc1
WD and tetratricopeptide repeats 1
chr17_+_34898931 0.078 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr11_-_33147400 0.067 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr19_-_46338632 0.063 ENSMUST00000051234.8
ENSMUST00000167861.1
 Cuedc2

CUE domain containing 2

chr7_+_3290553 0.030 ENSMUST00000096744.5
 Myadm
myeloid-associated differentiation marker
chr4_-_133339283 0.015 ENSMUST00000043305.7
 Wdtc1
WD and tetratricopeptide repeats 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.6 2.9 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.5 4.6 GO:0048733 sebaceous gland development(GO:0048733)
0.4 1.3 GO:0045472 response to ether(GO:0045472) negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of tumor necrosis factor secretion(GO:1904468)
0.4 1.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.3 1.2 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.3 2.0 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.3 1.1 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.2 2.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 1.4 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 0.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 4.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.1 4.8 GO:0035690 cellular response to drug(GO:0035690)
0.1 0.4 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.1 0.6 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.8 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.6 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.9 GO:0060384 innervation(GO:0060384)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.2 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0042581 specific granule(GO:0042581)
0.1 1.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 4.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0097512 cardiac myofibril(GO:0097512)
0.0 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.0 2.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 1.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.5 4.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.1 1.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.6 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.2 GO:0031005 filamin binding(GO:0031005)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 4.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.3 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 2.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 3.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.8 GO:0045296 cadherin binding(GO:0045296)
0.0 3.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 2.2 GO:0003729 mRNA binding(GO:0003729)