Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.493

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 5.075 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 4.646 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_60893430 4.618 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_+_140607334 3.278 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_-_124779686 2.927 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr13_-_102906046 2.907 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 2.845 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_9100681 1.813 ENSMUST00000115365.1
 Tmem243
transmembrane protein 243, mitochondrial
chr10_+_128337761 1.767 ENSMUST00000005826.7
 Cs
citrate synthase
chr7_-_143460989 1.541 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr14_+_46760526 1.496 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr14_-_52104015 1.458 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr4_-_141599835 1.445 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr12_-_40037387 1.304 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr4_-_119294520 1.234 ENSMUST00000079644.6
 Ybx1
Y box protein 1
chr11_-_87108656 1.202 ENSMUST00000051395.8
 Prr11
proline rich 11
chr11_+_43682038 1.182 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chrX_+_106015699 1.172 ENSMUST00000033582.4
 Cox7b
cytochrome c oxidase subunit VIIb
chr18_+_4993795 1.102 ENSMUST00000153016.1
 Svil
supervillin
chr4_-_14621669 1.079 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.8 4.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 4.6 GO:0007530 sex determination(GO:0007530)
0.0 4.2 GO:0043010 camera-type eye development(GO:0043010)
0.7 3.3 GO:0007386 compartment pattern specification(GO:0007386)
0.3 2.1 GO:0019532 oxalate transport(GO:0019532)
0.0 1.9 GO:0051028 mRNA transport(GO:0051028)
0.1 1.8 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.4 1.5 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 1.5 GO:0060065 uterus development(GO:0060065)
0.1 1.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 1.3 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 1.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 1.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 1.0 GO:0001842 neural fold formation(GO:0001842)
0.1 1.0 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 1.0 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 1.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.3 0.8 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 0.8 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 1.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0000287 magnesium ion binding(GO:0000287)
0.1 5.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 3.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.1 3.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 2.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 1.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.4 GO:0031005 filamin binding(GO:0031005)
0.1 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)
0.2 1.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 1.0 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 0.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.7 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.6 GO:0042015 interleukin-20 binding(GO:0042015)