Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.493

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2






Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_55782500 5.075 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 4.646 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chrX_-_60893430 4.618 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr5_+_140607334 3.278 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_-_124779686 2.927 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr13_-_102906046 2.907 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 2.845 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_9100681 1.813 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr10_+_128337761 1.767 ENSMUST00000005826.7
Cs
citrate synthase
chr7_-_143460989 1.541 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr14_+_46760526 1.496 ENSMUST00000067426.4
Cdkn3
cyclin-dependent kinase inhibitor 3
chr14_-_52104015 1.458 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr4_-_141599835 1.445 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
Fblim1



filamin binding LIM protein 1



chr12_-_40037387 1.304 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr4_-_119294520 1.234 ENSMUST00000079644.6
Ybx1
Y box protein 1
chr11_-_87108656 1.202 ENSMUST00000051395.8
Prr11
proline rich 11
chr11_+_43682038 1.182 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chrX_+_106015699 1.172 ENSMUST00000033582.4
Cox7b
cytochrome c oxidase subunit VIIb
chr18_+_4993795 1.102 ENSMUST00000153016.1
Svil
supervillin
chr4_-_14621669 1.079 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr4_-_140774196 1.014 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr11_+_43681998 0.997 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr14_-_8666236 0.975 ENSMUST00000102996.3
4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr6_+_29694204 0.974 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr19_+_5490475 0.965 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr17_-_34000257 0.958 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
H2-K1




histocompatibility 2, K1, K region




chr10_+_88147061 0.881 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr10_+_88146992 0.862 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr5_+_138187485 0.831 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr16_+_52031549 0.811 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr7_+_29983948 0.784 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr9_-_20959785 0.713 ENSMUST00000177754.1
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr15_+_81663889 0.679 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
L3mbtl2


l(3)mbt-like 2 (Drosophila)


chr9_-_100486788 0.650 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr9_+_66126611 0.599 ENSMUST00000034945.5
Fam96a
family with sequence similarity 96, member A
chr10_-_88146867 0.560 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr4_-_14621494 0.552 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr7_+_101896340 0.551 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr5_+_103425181 0.544 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr11_-_21371143 0.529 ENSMUST00000060895.5
Ugp2
UDP-glucose pyrophosphorylase 2
chr3_-_89101907 0.525 ENSMUST00000081848.8
Fdps
farnesyl diphosphate synthetase
chr4_-_14621805 0.511 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_+_121953213 0.466 ENSMUST00000037958.7
ENSMUST00000128366.1
Arhgap29

Rho GTPase activating protein 29

chr7_+_128744870 0.454 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr2_-_69712461 0.452 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr9_-_44113470 0.446 ENSMUST00000056328.5
Rnf26
ring finger protein 26
chr8_+_83972951 0.444 ENSMUST00000005606.6
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr7_-_27195727 0.441 ENSMUST00000163311.2
ENSMUST00000126211.1
Snrpa

small nuclear ribonucleoprotein polypeptide A

chr11_+_87109221 0.418 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr5_-_137072254 0.396 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr4_-_132075250 0.382 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr17_-_48432723 0.369 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr10_+_94575257 0.364 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr14_-_5863663 0.364 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chrX_-_160138375 0.354 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr7_-_38019505 0.350 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr18_+_24603952 0.343 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr12_+_84417196 0.328 ENSMUST00000183146.1
Rnf113a2
ring finger protein 113A2
chr5_+_138116903 0.322 ENSMUST00000062350.8
ENSMUST00000110961.2
ENSMUST00000080732.3
ENSMUST00000110960.2
ENSMUST00000142185.1
ENSMUST00000136425.1
ENSMUST00000110959.1
Zscan21






zinc finger and SCAN domain containing 21






chr9_-_54661870 0.311 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr8_+_33599608 0.302 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr7_+_101896817 0.286 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr3_-_34351685 0.284 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr3_-_90389884 0.270 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr3_+_94372794 0.269 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr11_-_43747963 0.268 ENSMUST00000048578.2
ENSMUST00000109278.1
Ttc1

tetratricopeptide repeat domain 1

chrM_+_8600 0.265 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr11_-_99230998 0.249 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr10_+_116301374 0.245 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr14_-_59365410 0.245 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr5_-_143909782 0.241 ENSMUST00000031613.4
ENSMUST00000100483.2
Aimp2

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

chr9_-_54661666 0.238 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr19_-_41933276 0.222 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr15_+_75993756 0.218 ENSMUST00000089669.4
Mapk15
mitogen-activated protein kinase 15
chr2_+_151494182 0.216 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr7_-_30552255 0.191 ENSMUST00000108165.1
ENSMUST00000153594.1
BC053749

cDNA sequence BC053749

chr2_+_36230426 0.174 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr5_-_34660068 0.158 ENSMUST00000041364.9
Nop14
NOP14 nucleolar protein
chrX_+_107255878 0.152 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr17_-_57031468 0.136 ENSMUST00000007814.8
Khsrp
KH-type splicing regulatory protein
chr14_+_4198185 0.123 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr6_+_68161415 0.121 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr2_+_110597298 0.116 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr14_-_6266620 0.105 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr12_+_4769278 0.097 ENSMUST00000020967.4
Pfn4
profilin family, member 4
chr5_+_115605642 0.097 ENSMUST00000094427.3
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr17_-_63863791 0.085 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr2_-_165388245 0.057 ENSMUST00000103084.3
Zfp334
zinc finger protein 334
chr5_-_140702241 0.038 ENSMUST00000077890.5
ENSMUST00000041783.7
ENSMUST00000142081.1
Iqce


IQ motif containing E


chr11_+_21572221 0.033 ENSMUST00000020568.3
ENSMUST00000131135.1
Wdpcp

WD repeat containing planar cell polarity effector

chr4_+_102570065 0.020 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr7_-_100964371 0.013 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_-_172027269 0.002 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_-_116424007 0.000 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 3.3 GO:0007386 compartment pattern specification(GO:0007386)
0.4 1.5 GO:0090365 regulation of mRNA modification(GO:0090365)
0.3 2.1 GO:0019532 oxalate transport(GO:0019532)
0.3 0.8 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.3 4.6 GO:0007530 sex determination(GO:0007530)
0.2 1.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 0.6 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.2 0.7 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.2 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.8 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.4 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.1 1.0 GO:0001842 neural fold formation(GO:0001842)
0.1 1.0 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.4 GO:0010757 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of vascular wound healing(GO:0061043) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 1.8 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 1.0 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 1.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.5 GO:0060065 uterus development(GO:0060065)
0.1 0.5 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.1 0.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 1.3 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.3 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.4 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.2 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 1.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 0.2 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 1.9 GO:0051028 mRNA transport(GO:0051028)
0.0 0.5 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 4.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 4.2 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.3 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 1.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.2 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 3.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0030689 Noc complex(GO:0030689)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 1.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 2.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 1.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 5.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.5 GO:0004337 geranyltranstransferase activity(GO:0004337)
0.1 1.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.4 GO:0031005 filamin binding(GO:0031005)
0.1 0.7 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1 0.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.5 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 5.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 3.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 1.0 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)