Motif ID: Nkx1-1_Nkx1-2
Z-value: 0.493
Transcription factors associated with Nkx1-1_Nkx1-2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx1-1 | ENSMUSG00000029112.5 | Nkx1-1 |
Nkx1-2 | ENSMUSG00000048528.7 | Nkx1-2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 4.6 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.7 | 3.3 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.4 | 1.5 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
0.3 | 2.1 | GO:0019532 | oxalate transport(GO:0019532) |
0.3 | 0.8 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
0.3 | 4.6 | GO:0007530 | sex determination(GO:0007530) |
0.2 | 1.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
0.2 | 0.6 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
0.2 | 0.7 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
0.2 | 0.5 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255) |
0.2 | 0.8 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
0.1 | 0.4 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
0.1 | 1.0 | GO:0001842 | neural fold formation(GO:0001842) |
0.1 | 1.0 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
0.1 | 0.4 | GO:0010757 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of vascular wound healing(GO:0061043) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
0.1 | 1.8 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.1 | 1.0 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
0.1 | 1.4 | GO:0033623 | regulation of integrin activation(GO:0033623) |
0.1 | 0.6 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
0.1 | 1.5 | GO:0060065 | uterus development(GO:0060065) |
0.1 | 0.5 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
0.1 | 0.8 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.1 | 0.2 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
0.1 | 0.4 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
0.0 | 0.5 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.3 | GO:0072539 | T-helper 17 cell differentiation(GO:0072539) |
0.0 | 1.3 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 0.3 | GO:0043144 | snoRNA processing(GO:0043144) |
0.0 | 0.4 | GO:0080111 | DNA demethylation(GO:0080111) |
0.0 | 0.6 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 1.0 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
0.0 | 0.1 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
0.0 | 0.2 | GO:0060510 | Type II pneumocyte differentiation(GO:0060510) |
0.0 | 1.2 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
0.0 | 0.5 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.0 | 0.2 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
0.0 | 0.2 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
0.0 | 0.2 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
0.0 | 1.9 | GO:0051028 | mRNA transport(GO:0051028) |
0.0 | 0.5 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.0 | 4.7 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
0.0 | 4.2 | GO:0043010 | camera-type eye development(GO:0043010) |
0.0 | 0.3 | GO:0046677 | response to antibiotic(GO:0046677) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
0.2 | 1.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.1 | 1.0 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.1 | 1.2 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
0.1 | 0.4 | GO:0042583 | chromaffin granule(GO:0042583) |
0.1 | 1.4 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.1 | 0.2 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.1 | 1.5 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.1 | 3.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.1 | 0.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
0.0 | 0.3 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 0.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.8 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.2 | GO:0030689 | Noc complex(GO:0030689) |
0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
0.0 | 0.4 | GO:0005685 | U1 snRNP(GO:0005685) |
0.0 | 0.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
0.0 | 0.3 | GO:0005684 | U2-type spliceosomal complex(GO:0005684) |
0.0 | 1.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.0 | 0.2 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 1.0 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.3 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
0.3 | 1.8 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.2 | 2.1 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.2 | 1.0 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
0.2 | 0.6 | GO:0042015 | interleukin-20 binding(GO:0042015) |
0.1 | 0.4 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
0.1 | 1.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
0.1 | 5.0 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.5 | GO:0004337 | geranyltranstransferase activity(GO:0004337) |
0.1 | 1.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.1 | 1.4 | GO:0031005 | filamin binding(GO:0031005) |
0.1 | 0.7 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
0.1 | 0.8 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.1 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.1 | 1.0 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
0.1 | 0.3 | GO:0008142 | oxysterol binding(GO:0008142) |
0.1 | 1.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.4 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
0.0 | 0.5 | GO:0032557 | pyrimidine ribonucleotide binding(GO:0032557) |
0.0 | 0.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 0.5 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
0.0 | 5.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 1.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.0 | 3.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
0.0 | 1.2 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 0.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.0 | 0.4 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
0.0 | 0.7 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.2 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
0.0 | 1.0 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |