Motif ID: Nkx2-1

Z-value: 0.750


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.792.7e-16Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103314944 12.205 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chr8_-_46294592 11.643 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr15_-_88978958 11.621 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr11_+_117849223 8.627 ENSMUST00000081387.4
Birc5
baculoviral IAP repeat-containing 5
chr14_-_47411666 7.876 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr4_+_89688196 7.641 ENSMUST00000052478.2
Dmrta1
doublesex and mab-3 related transcription factor like family A1
chrX_+_100730178 7.472 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr19_+_44493472 7.270 ENSMUST00000041163.4
Wnt8b
wingless related MMTV integration site 8b
chr11_+_117849286 6.789 ENSMUST00000093906.4
Birc5
baculoviral IAP repeat-containing 5
chr2_-_170406501 6.153 ENSMUST00000154650.1
Bcas1
breast carcinoma amplified sequence 1
chr16_+_48994185 6.029 ENSMUST00000117994.1
ENSMUST00000048374.5
C330027C09Rik

RIKEN cDNA C330027C09 gene

chr17_-_25570678 5.886 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8

SRY-box containing gene 8

chr5_+_128601106 5.710 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr4_-_141874879 5.517 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr11_+_63133068 5.215 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr17_+_47737030 5.037 ENSMUST00000086932.3
Tfeb
transcription factor EB
chr10_+_88091070 4.940 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr13_-_71963713 4.835 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr6_-_101377342 4.753 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr2_+_121506715 4.635 ENSMUST00000028676.5
Wdr76
WD repeat domain 76

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 15.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.3 11.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.6 11.6 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 9.3 GO:0032288 myelin assembly(GO:0032288)
0.1 8.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 7.7 GO:0006814 sodium ion transport(GO:0006814)
0.8 7.6 GO:0060179 male mating behavior(GO:0060179)
0.7 7.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 7.3 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
1.0 6.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 6.0 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.1 6.0 GO:0006959 humoral immune response(GO:0006959)
2.0 5.9 GO:0072034 renal vesicle induction(GO:0072034)
0.7 5.7 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
1.6 4.9 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 4.7 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.1 4.6 GO:0002339 B cell selection(GO:0002339)
1.1 4.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.3 3.9 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 3.5 GO:0016126 sterol biosynthetic process(GO:0016126)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 15.4 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 11.6 GO:0005901 caveola(GO:0005901)
0.0 10.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 9.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 8.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.5 7.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 7.5 GO:0005884 actin filament(GO:0005884)
0.1 4.8 GO:0031594 neuromuscular junction(GO:0031594)
0.7 4.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 4.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.8 3.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 3.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 3.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 3.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 3.1 GO:0097386 glial cell projection(GO:0097386)
0.0 3.0 GO:0009986 cell surface(GO:0009986)
0.2 2.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 2.6 GO:0043218 compact myelin(GO:0043218)
0.3 2.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.7 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.4 15.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 12.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 12.0 GO:0008565 protein transporter activity(GO:0008565)
0.3 8.7 GO:0005272 sodium channel activity(GO:0005272)
0.4 8.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 7.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.7 7.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 7.3 GO:0005109 frizzled binding(GO:0005109)
0.0 5.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 4.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 4.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 4.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 4.6 GO:0015643 toxic substance binding(GO:0015643)
0.3 4.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.8 4.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 3.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.4 3.5 GO:0070087 chromo shadow domain binding(GO:0070087)
1.0 3.1 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 3.0 GO:0001223 transcription coactivator binding(GO:0001223)