Motif ID: Nkx2-1
Z-value: 0.750
Transcription factors associated with Nkx2-1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-1 | ENSMUSG00000001496.9 | Nkx2-1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-1 | mm10_v2_chr12_-_56536895_56536937 | 0.79 | 2.7e-16 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.6 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 2.2 | 15.4 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 2.0 | 5.9 | GO:0072034 | renal vesicle induction(GO:0072034) |
| 1.6 | 4.9 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 1.3 | 3.9 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 1.1 | 4.6 | GO:0002339 | B cell selection(GO:0002339) |
| 1.1 | 4.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 1.0 | 6.2 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 1.0 | 3.1 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.9 | 2.7 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.8 | 7.6 | GO:0060179 | male mating behavior(GO:0060179) |
| 0.8 | 2.3 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.7 | 7.5 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.7 | 5.7 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.7 | 2.8 | GO:0035878 | nail development(GO:0035878) |
| 0.6 | 11.6 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
| 0.4 | 3.0 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
| 0.4 | 9.3 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.4 | 1.4 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 1.0 | GO:0007521 | muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596) |
| 0.3 | 2.1 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.3 | 1.4 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) regulation of cortisol biosynthetic process(GO:2000064) negative regulation of cortisol biosynthetic process(GO:2000065) |
| 0.3 | 2.7 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.3 | 2.5 | GO:0032306 | regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136) |
| 0.2 | 1.0 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.2 | 1.9 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 0.2 | 1.3 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.2 | 4.7 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.2 | 1.3 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.2 | 0.5 | GO:0072718 | response to cisplatin(GO:0072718) |
| 0.1 | 1.9 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.1 | 1.8 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.1 | 2.2 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 0.2 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.1 | 0.9 | GO:0042940 | D-amino acid transport(GO:0042940) |
| 0.1 | 3.0 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.1 | 0.9 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.1 | 6.0 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
| 0.1 | 6.0 | GO:0006959 | humoral immune response(GO:0006959) |
| 0.1 | 0.9 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.1 | 3.5 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.1 | 3.3 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.1 | 1.7 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.1 | 8.3 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 7.7 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.0 | 1.1 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 0.8 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 2.0 | GO:0035058 | nonmotile primary cilium assembly(GO:0035058) |
| 0.0 | 0.1 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 0.0 | 0.1 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
| 0.0 | 1.2 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.8 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.0 | 0.1 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 2.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 7.3 | GO:0016055 | Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738) |
| 0.0 | 0.2 | GO:0043248 | proteasome assembly(GO:0043248) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 15.4 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
| 0.8 | 3.9 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.7 | 4.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.5 | 4.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.5 | 7.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.3 | 1.7 | GO:0002177 | manchette(GO:0002177) |
| 0.3 | 2.5 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.3 | 3.5 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.2 | 2.8 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 1.8 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.2 | 1.3 | GO:0031415 | NatA complex(GO:0031415) |
| 0.2 | 3.1 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 2.0 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 2.6 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 1.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 1.9 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 11.6 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 4.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.8 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 7.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 8.2 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 3.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 10.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 9.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 2.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 0.9 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.1 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.1 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 3.8 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 3.0 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.1 | GO:0042629 | mast cell granule(GO:0042629) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.8 | 4.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.7 | 7.5 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.7 | 2.7 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.6 | 2.8 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.5 | 4.6 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.4 | 3.5 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.4 | 15.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.4 | 8.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.3 | 4.4 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.3 | 2.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.3 | 8.7 | GO:0005272 | sodium channel activity(GO:0005272) |
| 0.3 | 2.1 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.2 | 4.9 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 2.5 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.2 | 0.2 | GO:0031762 | alpha-1A adrenergic receptor binding(GO:0031691) alpha-1B adrenergic receptor binding(GO:0031692) follicle-stimulating hormone receptor binding(GO:0031762) |
| 0.2 | 7.3 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.2 | 3.0 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.2 | 1.2 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 0.1 | 1.4 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 1.3 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
| 0.1 | 4.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 12.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 1.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 1.0 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 12.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 2.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.9 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 4.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 0.9 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 1.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 16.7 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.1 | 3.9 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.0 | 0.1 | GO:0019958 | C-X-C chemokine binding(GO:0019958) |
| 0.0 | 0.5 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.0 | 2.5 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
| 0.0 | 7.9 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 3.0 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.0 | 0.2 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) |
| 0.0 | 0.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 2.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 2.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 5.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
