Motif ID: Nkx2-2

Z-value: 1.359


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.123.3e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_19418930 10.988 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 10.779 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr10_+_88091070 10.093 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr9_+_3034599 10.059 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 9.336 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3005125 9.244 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3015654 9.146 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 9.145 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_72438534 8.187 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 7.915 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr11_+_78301529 7.517 ENSMUST00000045026.3
 Spag5
sperm associated antigen 5
chr3_+_5218516 6.216 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chrX_+_9885622 5.676 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr19_-_5796924 5.238 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr4_+_59626189 4.865 ENSMUST00000070150.4
ENSMUST00000052420.6
 E130308A19Rik

RIKEN cDNA E130308A19 gene

chr2_-_140170528 4.773 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr2_+_62664279 4.611 ENSMUST00000028257.2
 Gca
grancalcin
chr9_-_8004585 4.604 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr13_+_51645232 4.604 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr1_-_166002613 4.231 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 16.1 GO:0070986 left/right axis specification(GO:0070986)
3.4 10.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.3 9.6 GO:0010960 magnesium ion homeostasis(GO:0010960)
2.5 7.5 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 7.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.4 6.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
1.9 5.8 GO:0051542 elastin biosynthetic process(GO:0051542)
0.2 5.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 5.3 GO:0008380 RNA splicing(GO:0008380)
1.3 5.2 GO:0035063 nuclear speck organization(GO:0035063)
0.1 4.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.5 4.7 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.9 4.6 GO:0060242 contact inhibition(GO:0060242)
0.1 4.6 GO:0007127 meiosis I(GO:0007127)
0.6 4.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.0 4.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 4.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.8 4.0 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 3.7 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.3 3.4 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.1 GO:0005882 intermediate filament(GO:0005882)
0.0 14.1 GO:0005615 extracellular space(GO:0005615)
0.0 10.5 GO:0005730 nucleolus(GO:0005730)
0.1 9.8 GO:0072562 blood microparticle(GO:0072562)
0.4 9.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 9.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 5.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 4.1 GO:0005902 microvillus(GO:0005902)
0.3 4.0 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 3.4 GO:0000922 spindle pole(GO:0000922)
0.8 3.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 3.2 GO:0016605 PML body(GO:0016605)
0.0 3.2 GO:0016607 nuclear speck(GO:0016607)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.8 GO:0005922 connexon complex(GO:0005922)
0.9 2.6 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.4 2.6 GO:0001940 male pronucleus(GO:0001940)
0.0 2.6 GO:0005681 spliceosomal complex(GO:0005681)
0.6 2.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 2.5 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.0 GO:0042802 identical protein binding(GO:0042802)
0.0 11.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.5 10.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 9.6 GO:0000049 tRNA binding(GO:0000049)
0.4 7.5 GO:0001848 complement binding(GO:0001848)
1.0 6.3 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
1.9 5.8 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.1 5.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 5.3 GO:0030695 GTPase regulator activity(GO:0030695)
0.2 4.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 4.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 4.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 4.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 4.0 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.0 3.5 GO:0008017 microtubule binding(GO:0008017)
0.0 3.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.6 3.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)