Motif ID: Nkx2-3

Z-value: 0.843


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_436123250.415.0e-04Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 17.848 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr12_+_38783455 13.543 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr2_+_73271925 8.250 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr6_-_6882068 6.441 ENSMUST00000142635.1
ENSMUST00000052609.8
Dlx5

distal-less homeobox 5

chr2_+_22622183 5.731 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr12_+_38780284 5.147 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr2_-_114013619 4.660 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr19_-_59170978 4.409 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr12_+_38780817 4.370 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr11_-_79504078 3.849 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr14_+_75455957 3.700 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr1_+_6734827 3.492 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr1_+_6730051 3.481 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr5_-_62766153 3.001 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 2.886 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr4_-_110292719 2.871 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_-_110286581 2.805 ENSMUST00000138972.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_+_38781093 2.662 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr6_+_112273758 2.654 ENSMUST00000032376.5
Lmcd1
LIM and cysteine-rich domains 1
chr1_+_187997821 2.630 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 43.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 7.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.6 6.6 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
2.1 6.4 GO:0060166 olfactory pit development(GO:0060166)
1.4 5.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 5.6 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.1 5.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 5.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.6 4.9 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 4.7 GO:0007601 visual perception(GO:0007601)
0.6 4.4 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.1 4.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.2 3.8 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.7 3.7 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
1.2 3.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 3.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 3.0 GO:0060539 diaphragm development(GO:0060539)
0.3 3.0 GO:0009404 toxin metabolic process(GO:0009404)
0.4 2.6 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 2.6 GO:0001867 complement activation, lectin pathway(GO:0001867)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 6.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 5.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 4.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.5 4.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 4.6 GO:0005815 microtubule organizing center(GO:0005815)
0.0 4.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 4.2 GO:0005922 connexon complex(GO:0005922)
0.1 3.6 GO:0043034 costamere(GO:0043034)
0.8 2.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.3 2.4 GO:0005818 aster(GO:0005818)
0.8 2.3 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.3 2.3 GO:0001940 male pronucleus(GO:0001940)
0.0 2.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 2.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.1 1.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 1.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 1.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 1.4 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 7.1 GO:0017091 AU-rich element binding(GO:0017091)
0.8 5.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 5.3 GO:0071837 HMG box domain binding(GO:0071837)
0.2 5.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 5.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 5.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.4 4.9 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.6 4.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 4.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 4.5 GO:0051015 actin filament binding(GO:0051015)
0.6 4.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 3.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.5 3.6 GO:0050693 LBD domain binding(GO:0050693)
0.1 3.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.6 3.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 2.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.8 2.4 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.5 2.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.5 2.3 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)