Motif ID: Nkx2-4

Z-value: 0.516


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.132.7e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 75 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_147186389 4.906 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr7_-_115824699 3.888 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr5_+_89027959 3.608 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr14_-_47418407 3.080 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr13_+_108316395 3.052 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr5_+_89028035 2.915 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr2_+_25180737 2.853 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr10_+_4611971 2.659 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr11_-_102579461 2.609 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr1_+_178798438 2.546 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr13_+_65512678 2.325 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr12_+_38781093 2.186 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr10_+_88091070 2.177 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr12_-_91746020 2.113 ENSMUST00000166967.1
 Ston2
stonin 2
chr11_+_110968016 2.051 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr10_+_20347788 2.031 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr13_-_105271039 2.003 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr6_+_30568367 1.876 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr3_+_76593550 1.806 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr15_+_99055164 1.803 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.5 GO:0015701 bicarbonate transport(GO:0015701)
1.6 4.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 3.9 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 3.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 3.6 GO:0010107 potassium ion import(GO:0010107)
0.0 3.1 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.3 2.9 GO:0014807 regulation of somitogenesis(GO:0014807)
0.7 2.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.8 2.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.7 2.2 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.3 2.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 2.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.2 2.0 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 2.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.8 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.1 1.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 1.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.4 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 1.3 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.4 1.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 3.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.5 GO:0005871 kinesin complex(GO:0005871)
0.0 2.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 2.0 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.6 1.8 GO:0044299 C-fiber(GO:0044299)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.2 GO:0032009 early phagosome(GO:0032009)
0.1 1.2 GO:0005922 connexon complex(GO:0005922)
0.1 1.2 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 0.8 GO:0097513 myosin II filament(GO:0097513)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0046982 protein heterodimerization activity(GO:0046982)
2.2 6.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.9 2.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 2.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 2.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.2 GO:0005243 gap junction channel activity(GO:0005243)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 0.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.9 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)