Motif ID: Nkx2-4

Z-value: 0.516


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.132.7e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_147186389 4.906 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr7_-_115824699 3.888 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr5_+_89027959 3.608 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr14_-_47418407 3.080 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr13_+_108316395 3.052 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr5_+_89028035 2.915 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr2_+_25180737 2.853 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr10_+_4611971 2.659 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr11_-_102579461 2.609 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr1_+_178798438 2.546 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr13_+_65512678 2.325 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr12_+_38781093 2.186 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr10_+_88091070 2.177 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr12_-_91746020 2.113 ENSMUST00000166967.1
 Ston2
stonin 2
chr11_+_110968016 2.051 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr10_+_20347788 2.031 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr13_-_105271039 2.003 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr6_+_30568367 1.876 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr3_+_76593550 1.806 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr15_+_99055164 1.803 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr12_+_38780817 1.748 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr13_-_66852017 1.670 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr2_+_156840966 1.656 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr6_+_134929089 1.561 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr11_+_110968056 1.557 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr6_+_134929118 1.537 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr15_-_26895049 1.474 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr19_-_6969746 1.414 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr10_+_128232065 1.283 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr19_+_55741810 1.266 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_-_71896047 1.231 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr1_+_97024681 1.228 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr8_+_66860215 1.224 ENSMUST00000118009.1
 Naf1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr10_+_42502197 1.197 ENSMUST00000105499.1
 Snx3
sorting nexin 3
chrX_+_101383726 1.162 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr3_+_52268337 1.139 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr6_-_97060407 1.081 ENSMUST00000089295.4
 Fam19a4
family with sequence similarity 19, member A4
chr17_+_86753900 0.937 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr9_+_108560422 0.853 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2
chr6_+_29398920 0.822 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr3_+_121291725 0.807 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr7_-_44670820 0.782 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr9_-_58159201 0.752 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr7_-_100932140 0.673 ENSMUST00000107032.1
 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr8_+_4248188 0.661 ENSMUST00000110993.1
 Gm14378
predicted gene 14378
chr3_+_96696379 0.595 ENSMUST00000107076.3
 Pias3
protein inhibitor of activated STAT 3
chr16_+_32419696 0.524 ENSMUST00000014220.8
ENSMUST00000080316.7
 Tctex1d2

Tctex1 domain containing 2

chr7_-_132813095 0.479 ENSMUST00000106165.1
 Fam53b
family with sequence similarity 53, member B
chr3_-_110250963 0.416 ENSMUST00000106567.1
 Prmt6
protein arginine N-methyltransferase 6
chr9_-_58158498 0.350 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr6_+_94500313 0.310 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr11_+_98863610 0.309 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr3_-_59220150 0.296 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr2_+_157456917 0.267 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr8_+_11556061 0.264 ENSMUST00000054399.4
 Ing1
inhibitor of growth family, member 1
chr12_-_105685235 0.245 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr2_+_169632996 0.241 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr14_+_55672235 0.230 ENSMUST00000002397.5
 Gmpr2
guanosine monophosphate reductase 2
chr8_+_45627946 0.215 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr17_-_25844417 0.206 ENSMUST00000176591.1
 Rhot2
ras homolog gene family, member T2
chr13_+_3478226 0.181 ENSMUST00000181708.1
ENSMUST00000180836.1
ENSMUST00000180567.1
 2810429I04Rik


RIKEN cDNA 2810429I04 gene


chr2_-_93046053 0.170 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr17_-_25844514 0.156 ENSMUST00000176709.1
 Rhot2
ras homolog gene family, member T2
chr17_+_70522083 0.147 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr1_+_16105774 0.134 ENSMUST00000027053.7
 Rdh10
retinol dehydrogenase 10 (all-trans)
chr17_-_51832666 0.097 ENSMUST00000144331.1
 Satb1
special AT-rich sequence binding protein 1
chr18_-_3281036 0.096 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr14_+_48446128 0.094 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr17_+_70522149 0.093 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr2_+_169633517 0.090 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr4_-_40279389 0.047 ENSMUST00000108108.2
ENSMUST00000095128.3
 Ndufb6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6

chr8_-_31739763 0.042 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr4_-_108848619 0.036 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr19_-_45742873 0.009 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr11_+_49247462 0.000 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.8 2.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.7 2.2 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.7 2.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 3.9 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.4 1.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.3 6.5 GO:0015701 bicarbonate transport(GO:0015701)
0.3 2.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 2.9 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 2.0 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 1.1 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 0.9 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 3.6 GO:0010107 potassium ion import(GO:0010107)
0.1 1.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 3.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.4 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.3 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 1.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.2 GO:0046037 GMP metabolic process(GO:0046037) guanosine-containing compound catabolic process(GO:1901069)
0.1 1.2 GO:1904872 regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.1 2.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 1.3 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 2.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 1.8 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0060431 primary lung bud formation(GO:0060431)
0.0 1.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.4 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.6 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 3.1 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.0 0.2 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.4 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.2 GO:0044804 nucleophagy(GO:0044804)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0044299 C-fiber(GO:0044299)
0.2 3.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.2 GO:0032009 early phagosome(GO:0032009)
0.1 2.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:0097513 myosin II filament(GO:0097513)
0.1 1.2 GO:0005922 connexon complex(GO:0005922)
0.1 1.2 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 2.5 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 5.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.0 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.9 2.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 0.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 2.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 3.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.2 GO:0005243 gap junction channel activity(GO:0005243)
0.1 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 0.9 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.4 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.6 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 7.0 GO:0046982 protein heterodimerization activity(GO:0046982)