Motif ID: Nkx2-5

Z-value: 0.760


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_88978958 19.369 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr18_-_31949571 9.988 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr8_-_46294592 8.439 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr1_+_172341197 6.918 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr12_+_74297474 4.632 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr15_-_54919961 3.979 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr4_+_103619580 3.599 ENSMUST00000106827.1
 Dab1
disabled 1
chr15_-_54920115 3.303 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr12_+_37880700 3.152 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr6_-_101377342 3.029 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr3_+_52268337 3.028 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr12_+_91400990 2.630 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr13_+_30136498 2.370 ENSMUST00000047311.8
 Mboat1
membrane bound O-acyltransferase domain containing 1
chr11_-_101987004 2.117 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr8_+_124793061 2.050 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr7_+_128246812 1.832 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr2_+_52038005 1.732 ENSMUST00000065927.5
 Tnfaip6
tumor necrosis factor alpha induced protein 6
chr14_+_80000292 1.726 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr15_-_10470490 1.589 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr7_+_128246953 1.588 ENSMUST00000167965.1
 Tgfb1i1
transforming growth factor beta 1 induced transcript 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 19.4 GO:0047484 regulation of response to osmotic stress(GO:0047484)
1.1 10.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.5 8.4 GO:0097154 GABAergic neuron differentiation(GO:0097154)
1.0 7.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
2.3 6.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
1.2 3.6 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.5 3.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 3.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.4 3.0 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 2.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 2.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.0 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 1.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.7 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.2 1.5 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 1.5 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.7 1.4 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.5 1.4 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.3 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.4 GO:0005901 caveola(GO:0005901)
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.5 6.5 GO:0097449 astrocyte projection(GO:0097449)
0.0 3.6 GO:0005903 brush border(GO:0005903)
0.0 3.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 3.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.1 GO:0001772 immunological synapse(GO:0001772)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:1990391 DNA repair complex(GO:1990391)
0.2 1.2 GO:0031415 NatA complex(GO:0031415)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.0 1.0 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0031985 Golgi cisterna(GO:0031985)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.4 GO:0008565 protein transporter activity(GO:0008565)
0.0 9.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 8.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.8 7.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
2.3 6.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 6.2 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.1 3.6 GO:0042169 SH2 domain binding(GO:0042169)
0.4 3.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 3.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 2.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.1 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.1 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.4 1.4 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.3 GO:0019841 retinol binding(GO:0019841)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)