Motif ID: Nkx2-5

Z-value: 0.760


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_88978958 19.369 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr18_-_31949571 9.988 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr8_-_46294592 8.439 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr1_+_172341197 6.918 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr12_+_74297474 4.632 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr15_-_54919961 3.979 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr4_+_103619580 3.599 ENSMUST00000106827.1
 Dab1
disabled 1
chr15_-_54920115 3.303 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr12_+_37880700 3.152 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr6_-_101377342 3.029 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr3_+_52268337 3.028 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr12_+_91400990 2.630 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr13_+_30136498 2.370 ENSMUST00000047311.8
 Mboat1
membrane bound O-acyltransferase domain containing 1
chr11_-_101987004 2.117 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr8_+_124793061 2.050 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr7_+_128246812 1.832 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr2_+_52038005 1.732 ENSMUST00000065927.5
 Tnfaip6
tumor necrosis factor alpha induced protein 6
chr14_+_80000292 1.726 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr15_-_10470490 1.589 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr7_+_128246953 1.588 ENSMUST00000167965.1
 Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr5_-_8997324 1.501 ENSMUST00000003720.4
 Crot
carnitine O-octanoyltransferase
chr11_-_78550777 1.485 ENSMUST00000103242.4
 Tmem97
transmembrane protein 97
chr19_-_57360668 1.463 ENSMUST00000181921.1
 B230217O12Rik
RIKEN cDNA B230217O12 gene
chr2_+_131234043 1.444 ENSMUST00000041362.5
ENSMUST00000110199.2
 Mavs

mitochondrial antiviral signaling protein

chr2_-_173276144 1.442 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr9_-_53536608 1.437 ENSMUST00000150244.1
 Atm
ataxia telangiectasia mutated homolog (human)
chr14_+_70530819 1.422 ENSMUST00000047331.6
 Lgi3
leucine-rich repeat LGI family, member 3
chr1_-_163725123 1.353 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chrX_-_75416533 1.349 ENSMUST00000033542.4
 Mtcp1
mature T cell proliferation 1
chr9_+_98422961 1.283 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr19_+_26753588 1.221 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_138085083 1.219 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
 Zkscan1


zinc finger with KRAB and SCAN domains 1


chr12_+_103314944 1.203 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr16_+_44139821 1.202 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr13_+_30136529 1.136 ENSMUST00000152798.1
 Mboat1
membrane bound O-acyltransferase domain containing 1
chr4_+_62619515 1.095 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr2_-_127792467 1.029 ENSMUST00000135091.1
 1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr5_-_124327812 1.025 ENSMUST00000184951.1
 Mphosph9
M-phase phosphoprotein 9
chr1_-_66817536 1.023 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr5_-_124327883 0.914 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr15_-_82224330 0.829 ENSMUST00000089161.2
ENSMUST00000109535.2
 Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chrX_-_75416562 0.815 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
 Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr8_-_95113334 0.776 ENSMUST00000169353.1
 Kifc3
kinesin family member C3
chr4_+_42714926 0.719 ENSMUST00000178454.1
 Gm21955
predicted gene, 21955
chr2_-_5942740 0.691 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
 Dhtkd1


dehydrogenase E1 and transketolase domain containing 1


chr11_+_4620067 0.684 ENSMUST00000109941.1
 Gm11032
predicted gene 11032
chr4_+_137594140 0.682 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
 Usp48



ubiquitin specific peptidase 48



chr14_+_47001336 0.646 ENSMUST00000125113.1
 Samd4
sterile alpha motif domain containing 4
chr18_+_49832622 0.632 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr17_+_88440711 0.616 ENSMUST00000112238.2
ENSMUST00000155640.1
 Foxn2

forkhead box N2

chr10_-_42018363 0.592 ENSMUST00000162405.1
ENSMUST00000095729.4
ENSMUST00000161081.1
ENSMUST00000160262.2
 Armc2



armadillo repeat containing 2



chr2_+_174076296 0.563 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
 Stx16


syntaxin 16


chr6_-_115853346 0.550 ENSMUST00000032469.6
 Mbd4
methyl-CpG binding domain protein 4
chr18_-_79109391 0.550 ENSMUST00000025430.8
ENSMUST00000161465.2
 Setbp1

SET binding protein 1

chr4_-_140323302 0.528 ENSMUST00000063789.2
 Gm9867
predicted gene 9867
chr7_-_126897424 0.505 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr12_+_4082596 0.499 ENSMUST00000049584.5
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr16_-_44139630 0.475 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr14_+_21500879 0.397 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr5_-_5265224 0.388 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr17_-_29716969 0.372 ENSMUST00000129091.1
ENSMUST00000128751.1
 Ccdc167

coiled-coil domain containing 167

chr1_-_86359455 0.370 ENSMUST00000027438.6
 Ncl
nucleolin
chr12_+_4082574 0.284 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr17_-_56609689 0.284 ENSMUST00000052832.5
 2410015M20Rik
RIKEN cDNA 2410015M20 gene
chr1_+_128103297 0.283 ENSMUST00000036288.4
 R3hdm1
R3H domain containing 1
chr2_+_23069210 0.276 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr2_+_120609383 0.241 ENSMUST00000124187.1
 Haus2
HAUS augmin-like complex, subunit 2
chr5_-_106624390 0.240 ENSMUST00000112694.1
 Zfp644
zinc finger protein 644
chr7_+_18991245 0.233 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
 Mypop


Myb-related transcription factor, partner of profilin


chr2_+_69897220 0.231 ENSMUST00000055758.9
ENSMUST00000112251.2
 Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr19_-_40271506 0.229 ENSMUST00000068439.6
 Pdlim1
PDZ and LIM domain 1 (elfin)
chr6_+_115853470 0.215 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
 Ift122


intraflagellar transport 122


chr16_+_44173271 0.203 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr15_+_76351303 0.182 ENSMUST00000023212.8
ENSMUST00000160172.1
 Maf1

MAF1 homolog (S. cerevisiae)

chr15_-_99457712 0.171 ENSMUST00000161948.1
 Nckap5l
NCK-associated protein 5-like
chr16_+_44943737 0.159 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr9_-_20976762 0.153 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr8_+_113643206 0.147 ENSMUST00000034219.4
ENSMUST00000095173.1
 Syce1l

synaptonemal complex central element protein 1 like

chr10_-_127311740 0.146 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chrX_+_114474312 0.139 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chrX_-_64276937 0.106 ENSMUST00000114679.1
ENSMUST00000069926.7
 Slitrk4

SLIT and NTRK-like family, member 4

chr15_-_99457742 0.105 ENSMUST00000023747.7
 Nckap5l
NCK-associated protein 5-like
chr4_-_108625216 0.100 ENSMUST00000166069.1
 Gm20731
predicted gene, 20731
chr3_+_103739366 0.091 ENSMUST00000106852.1
 Gm10964
predicted gene 10964
chr14_+_20674311 0.085 ENSMUST00000048657.8
 Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr4_-_126968124 0.071 ENSMUST00000106108.2
 Zmym4
zinc finger, MYM-type 4
chr6_-_83572429 0.057 ENSMUST00000068054.7
 Stambp
STAM binding protein
chr17_+_35379608 0.043 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr2_+_80315461 0.034 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 19.4 GO:0047484 regulation of response to osmotic stress(GO:0047484)
2.3 6.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
1.2 3.6 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.1 10.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
1.0 7.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.7 1.4 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.5 3.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.5 1.4 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.5 8.4 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 3.0 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.3 1.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 0.8 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.3 0.8 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 2.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 1.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.2 1.5 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.1 1.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 3.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.4 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 2.0 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) embryonic heart tube left/right pattern formation(GO:0060971)
0.1 0.2 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 1.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.5 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 1.5 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.1 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324) meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764)
0.0 0.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.7 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.5 GO:0097449 astrocyte projection(GO:0097449)
0.2 19.4 GO:0005901 caveola(GO:0005901)
0.2 1.2 GO:0031415 NatA complex(GO:0031415)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.4 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.2 GO:0071564 npBAF complex(GO:0071564)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 2.1 GO:0001772 immunological synapse(GO:0001772)
0.0 3.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:1990391 DNA repair complex(GO:1990391)
0.0 3.6 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 3.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.0 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.6 GO:0031985 Golgi cisterna(GO:0031985)
0.0 3.4 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.8 7.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.4 3.4 GO:0048495 Roundabout binding(GO:0048495)
0.4 1.4 GO:0050700 CARD domain binding(GO:0050700)
0.3 3.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.3 GO:0019841 retinol binding(GO:0019841)
0.2 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 3.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 6.2 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.2 19.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.1 3.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.7 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.4 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 2.1 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.1 8.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 9.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.2 GO:0080084 RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0 0.5 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)