Motif ID: Nkx2-9

Z-value: 0.855


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_566132910.244.6e-02Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_30065333 12.725 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr6_+_135362931 10.825 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr15_-_88978958 10.797 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr12_-_56536895 10.727 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr11_+_117849223 10.024 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr13_-_71963713 8.434 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr3_+_122419772 7.962 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr11_+_117849286 7.919 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr8_-_46294592 7.869 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr6_+_66896397 7.662 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
 Gng12





guanine nucleotide binding protein (G protein), gamma 12





chr10_+_88091070 7.435 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr7_-_142576492 6.786 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr9_+_57504012 6.748 ENSMUST00000080514.7
 Rpp25
ribonuclease P/MRP 25 subunit
chr6_-_6217023 6.713 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr11_+_88718442 6.324 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr8_+_95633500 5.884 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)
chr6_-_101377342 5.841 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr2_+_173022360 5.481 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr6_+_66896480 5.212 ENSMUST00000114222.1
 Gng12
guanine nucleotide binding protein (G protein), gamma 12
chr2_+_20737306 5.188 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 17.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
4.2 12.7 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
2.2 10.8 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.6 10.8 GO:0032060 bleb assembly(GO:0032060)
3.6 10.7 GO:0021759 globus pallidus development(GO:0021759)
0.2 8.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.5 7.9 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 7.5 GO:0008033 tRNA processing(GO:0008033)
2.5 7.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.6 6.8 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.7 6.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 6.0 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 5.9 GO:0006260 DNA replication(GO:0006260)
0.5 5.5 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 5.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 5.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 4.5 GO:0016126 sterol biosynthetic process(GO:0016126)
1.5 4.4 GO:0036292 DNA rewinding(GO:0036292)
1.4 4.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
1.0 3.9 GO:0002339 B cell selection(GO:0002339)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.0 17.9 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 16.6 GO:0005667 transcription factor complex(GO:0005667)
0.3 12.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 12.5 GO:0016363 nuclear matrix(GO:0016363)
0.1 10.8 GO:0005901 caveola(GO:0005901)
0.0 8.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 8.6 GO:0005844 polysome(GO:0005844)
0.0 5.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 4.5 GO:0005652 nuclear lamina(GO:0005652)
0.1 4.4 GO:0043596 nuclear replication fork(GO:0043596)
0.6 3.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 3.9 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 3.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 2.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.6 GO:0031594 neuromuscular junction(GO:0031594)
0.1 2.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.9 GO:0043027 Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.3 12.9 GO:0042301 phosphate ion binding(GO:0042301)
0.5 12.7 GO:0008432 JUN kinase binding(GO:0008432)
0.1 11.4 GO:0008565 protein transporter activity(GO:0008565)
0.9 10.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 7.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
1.7 6.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.6 6.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 6.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 5.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.5 5.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.6 4.5 GO:0070087 chromo shadow domain binding(GO:0070087)
0.4 4.4 GO:0036310 annealing helicase activity(GO:0036310)
0.0 4.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 4.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 3.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 3.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 3.8 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.5 3.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 3.1 GO:0005044 scavenger receptor activity(GO:0005044)