Motif ID: Nkx2-9
Z-value: 0.855
Transcription factors associated with Nkx2-9:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-9 | ENSMUSG00000058669.7 | Nkx2-9 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-9 | mm10_v2_chr12_-_56613270_56613291 | 0.24 | 4.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.2 | 12.7 | GO:0021557 | oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
3.6 | 10.7 | GO:0021759 | globus pallidus development(GO:0021759) |
2.6 | 17.9 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
2.5 | 7.4 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
2.2 | 10.8 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
1.7 | 6.7 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
1.5 | 4.4 | GO:0036292 | DNA rewinding(GO:0036292) |
1.4 | 4.2 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
1.0 | 3.9 | GO:0002339 | B cell selection(GO:0002339) |
0.8 | 3.1 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.6 | 1.9 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
0.6 | 6.8 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
0.6 | 10.8 | GO:0032060 | bleb assembly(GO:0032060) |
0.6 | 2.3 | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
0.5 | 7.9 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.5 | 5.5 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
0.4 | 2.8 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
0.4 | 2.4 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
0.4 | 3.9 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.4 | 2.2 | GO:0002934 | desmosome organization(GO:0002934) |
0.3 | 1.7 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
0.3 | 2.0 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.3 | 1.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.3 | 1.4 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
0.3 | 1.5 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
0.2 | 0.7 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
0.2 | 8.0 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.2 | 1.2 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
0.2 | 0.6 | GO:2000983 | regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984) |
0.2 | 1.4 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.1 | 1.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 5.0 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.1 | 1.3 | GO:0060539 | diaphragm development(GO:0060539) |
0.1 | 1.7 | GO:0055070 | copper ion homeostasis(GO:0055070) |
0.1 | 0.5 | GO:0042940 | D-amino acid transport(GO:0042940) |
0.1 | 0.3 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
0.1 | 4.5 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
0.1 | 2.3 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
0.1 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.1 | 7.5 | GO:0008033 | tRNA processing(GO:0008033) |
0.1 | 3.3 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.1 | 0.2 | GO:0048318 | axial mesoderm development(GO:0048318) |
0.0 | 0.2 | GO:0019249 | lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) |
0.0 | 2.9 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
0.0 | 1.9 | GO:0007588 | excretion(GO:0007588) |
0.0 | 2.3 | GO:0007528 | neuromuscular junction development(GO:0007528) |
0.0 | 5.2 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
0.0 | 0.5 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
0.0 | 2.6 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
0.0 | 0.9 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 0.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.5 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
0.0 | 5.9 | GO:0006260 | DNA replication(GO:0006260) |
0.0 | 6.0 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.0 | 17.9 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
0.6 | 3.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.3 | 1.4 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.3 | 12.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.3 | 4.5 | GO:0005652 | nuclear lamina(GO:0005652) |
0.2 | 2.6 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.1 | 1.9 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.1 | 8.6 | GO:0005844 | polysome(GO:0005844) |
0.1 | 12.5 | GO:0016363 | nuclear matrix(GO:0016363) |
0.1 | 4.4 | GO:0043596 | nuclear replication fork(GO:0043596) |
0.1 | 1.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 1.3 | GO:0001527 | microfibril(GO:0001527) |
0.1 | 2.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
0.1 | 10.8 | GO:0005901 | caveola(GO:0005901) |
0.1 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.1 | 3.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.1 | 2.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.1 | 0.3 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
0.0 | 1.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 16.6 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 3.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
0.0 | 2.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 2.0 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 5.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 8.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 0.5 | GO:0097440 | apical dendrite(GO:0097440) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 6.7 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
1.3 | 12.9 | GO:0042301 | phosphate ion binding(GO:0042301) |
0.9 | 10.7 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.7 | 2.9 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
0.6 | 6.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.6 | 4.5 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.5 | 3.3 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
0.5 | 12.7 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.5 | 5.0 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.4 | 17.9 | GO:0043027 | Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.4 | 3.9 | GO:0015643 | toxic substance binding(GO:0015643) |
0.4 | 7.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.4 | 4.4 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.3 | 1.4 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
0.3 | 4.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.2 | 2.8 | GO:0070636 | single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694) |
0.2 | 1.9 | GO:0034711 | inhibin binding(GO:0034711) |
0.2 | 3.8 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.2 | 1.9 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
0.2 | 1.3 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.2 | 3.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.2 | 0.3 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
0.1 | 11.4 | GO:0008565 | protein transporter activity(GO:0008565) |
0.1 | 0.9 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.1 | 3.9 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.1 | 1.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 0.8 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
0.1 | 1.9 | GO:0070402 | NADPH binding(GO:0070402) |
0.1 | 2.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 2.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.1 | 2.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 5.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.1 | 0.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.1 | 2.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 0.2 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
0.0 | 2.6 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
0.0 | 1.7 | GO:0005109 | frizzled binding(GO:0005109) |
0.0 | 0.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.0 | 0.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.0 | 1.7 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 2.1 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
0.0 | 2.0 | GO:0051018 | protein kinase A binding(GO:0051018) |
0.0 | 4.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 2.2 | GO:0031490 | chromatin DNA binding(GO:0031490) |
0.0 | 6.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
0.0 | 0.5 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 1.8 | GO:0019843 | rRNA binding(GO:0019843) |
0.0 | 1.3 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.0 | 3.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
0.0 | 1.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |