Motif ID: Nkx3-1

Z-value: 0.795


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 138 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_13324160 12.323 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chrX_+_100625737 11.188 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr9_+_78191966 9.644 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr3_-_57575907 9.152 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575760 8.914 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr4_-_132757162 8.891 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr6_+_128362919 8.368 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr9_+_72438534 7.485 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chrX_+_164269371 7.391 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr17_+_56304313 6.977 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr9_+_72438519 6.910 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr1_-_163289214 6.427 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr10_-_13324250 6.347 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chr8_+_114133557 5.561 ENSMUST00000073521.5
ENSMUST00000066514.6
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr9_-_20976762 5.406 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr13_+_51408618 5.326 ENSMUST00000087978.3
 S1pr3
sphingosine-1-phosphate receptor 3
chr8_+_114133635 5.291 ENSMUST00000147605.1
ENSMUST00000134593.1
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr10_+_94514825 4.944 ENSMUST00000065060.5
 Tmcc3
transmembrane and coiled coil domains 3
chr17_-_25727364 4.925 ENSMUST00000170070.1
ENSMUST00000048054.7
 Chtf18

CTF18, chromosome transmission fidelity factor 18

chr8_-_123318553 4.855 ENSMUST00000118395.1
ENSMUST00000035495.8
 Fanca

Fanconi anemia, complementation group A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 18.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.9 14.4 GO:0070986 left/right axis specification(GO:0070986)
1.6 11.2 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
3.6 10.9 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
1.3 8.9 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.0 8.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.5 7.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 6.8 GO:0060348 bone development(GO:0060348)
0.5 6.4 GO:0048664 neuron fate determination(GO:0048664)
0.2 6.2 GO:0030224 monocyte differentiation(GO:0030224)
1.8 5.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.7 5.3 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.7 4.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.6 4.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.6 4.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.5 4.6 GO:0019240 citrulline biosynthetic process(GO:0019240)
1.4 4.3 GO:0007525 somatic muscle development(GO:0007525)
0.8 4.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 4.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2 3.7 GO:0006379 mRNA cleavage(GO:0006379)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 14.4 GO:0005882 intermediate filament(GO:0005882)
0.2 8.9 GO:0032420 stereocilium(GO:0032420)
0.1 8.7 GO:0005871 kinesin complex(GO:0005871)
0.1 7.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 7.0 GO:0000791 euchromatin(GO:0000791)
0.6 4.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.4 4.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 4.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 4.3 GO:0070938 contractile ring(GO:0070938)
0.0 3.8 GO:0072562 blood microparticle(GO:0072562)
0.1 3.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 3.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.7 GO:0005884 actin filament(GO:0005884)
0.5 2.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 2.0 GO:0005712 chiasma(GO:0005712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.0 GO:0003714 transcription corepressor activity(GO:0003714)
3.6 10.9 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 10.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
1.3 10.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 10.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
1.1 8.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.6 8.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.6 7.4 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
2.3 7.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 6.4 GO:0071837 HMG box domain binding(GO:0071837)
0.4 4.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 4.8 GO:0001848 complement binding(GO:0001848)
0.8 4.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 4.3 GO:0017166 vinculin binding(GO:0017166)
0.4 4.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 3.7 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 3.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 3.4 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 3.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)