Motif ID: Nkx6-2
Z-value: 0.763
Transcription factors associated with Nkx6-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx6-2 | ENSMUSG00000041309.11 | Nkx6-2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx6-2 | mm10_v2_chr7_-_139582790_139582808 | -0.21 | 8.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 4.0 | GO:0060023 | soft palate development(GO:0060023) |
| 1.2 | 3.5 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
| 1.1 | 8.5 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.7 | 2.6 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.6 | 2.3 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
| 0.5 | 3.8 | GO:0034047 | regulation of protein phosphatase type 2A activity(GO:0034047) |
| 0.5 | 2.4 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.5 | 4.7 | GO:0033603 | positive regulation of dopamine secretion(GO:0033603) |
| 0.4 | 2.1 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.3 | 0.7 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.3 | 3.2 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.3 | 1.1 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
| 0.2 | 1.2 | GO:0014719 | skeletal muscle satellite cell activation(GO:0014719) |
| 0.2 | 1.4 | GO:1902965 | protein localization to early endosome(GO:1902946) regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 0.2 | 2.9 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.2 | 1.9 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.2 | 0.6 | GO:1903463 | mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.1 | 0.4 | GO:0072356 | chromosome passenger complex localization to kinetochore(GO:0072356) |
| 0.1 | 0.9 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 1.9 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 0.9 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.1 | 0.6 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.1 | 0.9 | GO:2000809 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.1 | 0.6 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 1.7 | GO:0080111 | DNA demethylation(GO:0080111) |
| 0.1 | 1.3 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 0.9 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 0.4 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.4 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) astrocyte activation(GO:0048143) regulation of resting membrane potential(GO:0060075) |
| 0.1 | 0.6 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.1 | 0.6 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.1 | 0.6 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.1 | 4.5 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 2.6 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 0.5 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.2 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.5 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 1.6 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 0.2 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.0 | 0.5 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 0.0 | 2.0 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.0 | 0.1 | GO:1903887 | motile primary cilium assembly(GO:1903887) |
| 0.0 | 1.7 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.0 | 1.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.1 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.0 | 0.3 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.7 | GO:0005883 | neurofilament(GO:0005883) |
| 0.4 | 4.0 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.3 | 3.2 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.2 | 3.0 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.2 | 0.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 3.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 0.4 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 0.4 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 1.4 | GO:0051286 | cell tip(GO:0051286) |
| 0.1 | 1.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 2.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 1.9 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.6 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 1.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 2.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 2.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 8.5 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.9 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.4 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 1.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 2.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 5.8 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 2.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.7 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.2 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 0.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.5 | 4.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.4 | 1.3 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.4 | 2.6 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.3 | 3.8 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.2 | 4.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 3.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 0.6 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.2 | 0.9 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
| 0.2 | 2.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 2.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 3.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.9 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 2.9 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 2.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.4 | GO:0005138 | ciliary neurotrophic factor receptor binding(GO:0005127) interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.8 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.7 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 0.0 | 1.6 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.2 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.9 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 1.2 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 4.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 2.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 9.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 3.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 2.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.4 | GO:0005109 | frizzled binding(GO:0005109) |
