Motif ID: Nkx6-3_Dbx2_Barx2
Z-value: 0.444
Transcription factors associated with Nkx6-3_Dbx2_Barx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Barx2 | ENSMUSG00000032033.10 | Barx2 |
Dbx2 | ENSMUSG00000045608.6 | Dbx2 |
Nkx6-3 | ENSMUSG00000063672.6 | Nkx6-3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Dbx2 | mm10_v2_chr15_-_95655960_95655960 | 0.21 | 7.5e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 9.2 | GO:0019532 | oxalate transport(GO:0019532) |
0.5 | 2.1 | GO:1901642 | purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642) |
0.5 | 2.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.5 | 2.4 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
0.4 | 1.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.4 | 4.7 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.2 | 1.2 | GO:1900170 | prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
0.2 | 4.3 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.2 | 0.7 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
0.2 | 0.7 | GO:0009193 | pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048) |
0.2 | 0.9 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.1 | 0.9 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.1 | 0.7 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 1.6 | GO:0033572 | transferrin transport(GO:0033572) |
0.1 | 0.6 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.1 | 0.3 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 3.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.1 | 0.6 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 1.0 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
0.1 | 0.5 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.1 | 1.2 | GO:0032570 | response to progesterone(GO:0032570) |
0.1 | 0.3 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 0.3 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.1 | 0.2 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) |
0.1 | 3.0 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.1 | 0.3 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.1 | 0.3 | GO:0032275 | luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278) |
0.1 | 1.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.1 | 0.4 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.1 | 0.4 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.1 | 0.5 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
0.0 | 0.2 | GO:1901524 | regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525) |
0.0 | 1.5 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 0.5 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 0.6 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.0 | 0.2 | GO:0033762 | response to glucagon(GO:0033762) hyperosmotic salinity response(GO:0042538) |
0.0 | 0.2 | GO:0051012 | microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856) |
0.0 | 0.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 0.8 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.1 | GO:0030223 | neutrophil differentiation(GO:0030223) |
0.0 | 0.4 | GO:0051382 | kinetochore assembly(GO:0051382) |
0.0 | 0.4 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
0.0 | 0.3 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
0.0 | 0.1 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
0.0 | 0.1 | GO:0046469 | platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469) |
0.0 | 0.3 | GO:0097186 | amelogenesis(GO:0097186) |
0.0 | 0.1 | GO:0030242 | pexophagy(GO:0030242) |
0.0 | 1.2 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
0.0 | 0.1 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.0 | 0.1 | GO:0060527 | prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527) |
0.0 | 0.1 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
0.0 | 0.5 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.0 | 0.3 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
0.0 | 0.4 | GO:0009299 | mRNA transcription(GO:0009299) |
0.0 | 0.8 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
0.0 | 0.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.0 | GO:0035633 | negative regulation of epinephrine secretion(GO:0032811) maintenance of blood-brain barrier(GO:0035633) |
0.0 | 0.9 | GO:0030032 | lamellipodium assembly(GO:0030032) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 0.9 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.2 | 3.0 | GO:0042581 | specific granule(GO:0042581) |
0.2 | 1.2 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.2 | 3.0 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.2 | 3.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.1 | 2.0 | GO:0043205 | fibril(GO:0043205) |
0.1 | 1.2 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.1 | 0.3 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.1 | 0.7 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.1 | 0.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.0 | 1.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.0 | 0.6 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 0.3 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 3.2 | GO:0030315 | T-tubule(GO:0030315) |
0.0 | 0.2 | GO:0030689 | Noc complex(GO:0030689) |
0.0 | 0.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 6.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 0.2 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.0 | 0.2 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.0 | 0.1 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 0.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.4 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 1.6 | GO:0055037 | recycling endosome(GO:0055037) |
0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 0.1 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 0.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 9.2 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.7 | 2.1 | GO:0015217 | ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.6 | 2.4 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.4 | 2.0 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.3 | 0.9 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.3 | 0.8 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.2 | 4.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.2 | 3.0 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.2 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 1.0 | GO:0018741 | alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902) |
0.1 | 0.4 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.1 | 0.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.1 | 1.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.1 | 0.7 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
0.1 | 0.5 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.1 | 4.3 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
0.1 | 0.6 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
0.1 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
0.1 | 3.0 | GO:0045296 | cadherin binding(GO:0045296) |
0.1 | 0.3 | GO:0034235 | GPI anchor binding(GO:0034235) |
0.1 | 0.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.1 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.0 | 0.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 0.9 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.0 | 0.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.1 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
0.0 | 0.3 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
0.0 | 1.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 1.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.6 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 0.2 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 1.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.0 | 0.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.3 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
0.0 | 0.7 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
0.0 | 0.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.0 | 1.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.0 | 1.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |