Motif ID: Nr1i2

Z-value: 0.741


Transcription factors associated with Nr1i2:

Gene SymbolEntrez IDGene Name
Nr1i2 ENSMUSG00000022809.4 Nr1i2



Activity profile for motif Nr1i2.

activity profile for motif Nr1i2


Sorted Z-values histogram for motif Nr1i2

Sorted Z-values for motif Nr1i2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_53975246 5.467 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr11_-_26210553 4.678 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr5_+_37028329 3.800 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr4_-_82505274 3.717 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr3_-_80802789 3.633 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr18_+_69345721 3.605 ENSMUST00000078486.6
ENSMUST00000114982.1
 Tcf4

transcription factor 4

chr4_+_104367549 3.581 ENSMUST00000106830.2
 Dab1
disabled 1
chr8_+_84723003 3.409 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr1_-_162478004 3.290 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr6_+_115134899 3.282 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr17_+_55445375 3.205 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr17_-_37023349 3.170 ENSMUST00000102665.4
 Mog
myelin oligodendrocyte glycoprotein
chr9_-_121495678 3.127 ENSMUST00000035120.4
 Cck
cholecystokinin
chr11_+_67586520 3.075 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_98741805 3.002 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha
chr11_-_6065538 2.989 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr7_+_25306085 2.933 ENSMUST00000119703.1
ENSMUST00000108409.1
 Tmem145

transmembrane protein 145

chr1_+_17145357 2.904 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr18_+_67933257 2.861 ENSMUST00000063775.3
 Ldlrad4
low density lipoprotein receptor class A domain containing 4
chr2_-_25469742 2.784 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 199 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.7 6.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6 6.2 GO:0042118 endothelial cell activation(GO:0042118)
1.5 5.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 4.5 GO:0007379 segment specification(GO:0007379)
0.2 4.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 3.8 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
1.2 3.6 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 3.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.2 3.5 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.0 3.5 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 3.5 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.4 3.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.3 3.2 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.2 3.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 3.2 GO:0030041 actin filament polymerization(GO:0030041)
1.0 3.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
1.0 3.0 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.6 2.9 GO:0019236 response to pheromone(GO:0019236)
0.6 2.9 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.1 GO:0060076 excitatory synapse(GO:0060076)
0.1 6.8 GO:0042734 presynaptic membrane(GO:0042734)
0.3 6.4 GO:0031430 M band(GO:0031430)
0.5 6.0 GO:0043083 synaptic cleft(GO:0043083)
0.3 5.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 5.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 4.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 4.4 GO:0098984 neuron to neuron synapse(GO:0098984)
0.2 4.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 3.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 3.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.6 3.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 3.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 3.1 GO:0043203 axon hillock(GO:0043203)
0.1 3.0 GO:0051233 spindle midzone(GO:0051233)
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 2.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.7 GO:0010008 endosome membrane(GO:0010008)
0.6 2.6 GO:0097165 nuclear stress granule(GO:0097165)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 6.5 GO:0003714 transcription corepressor activity(GO:0003714)
1.6 6.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 5.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.0 5.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 4.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 4.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 4.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.8 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 3.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.7 GO:0050811 GABA receptor binding(GO:0050811)
0.6 3.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 3.5 GO:0042169 SH2 domain binding(GO:0042169)
0.0 3.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 3.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 3.4 GO:0030674 protein binding, bridging(GO:0030674)
1.1 3.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
1.0 3.0 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.2 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 2.9 GO:0038191 neuropilin binding(GO:0038191)