Motif ID: Nr2c2

Z-value: 1.133


Transcription factors associated with Nr2c2:

Gene SymbolEntrez IDGene Name
Nr2c2 ENSMUSG00000005893.8 Nr2c2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c2mm10_v2_chr6_+_92091378_92091390-0.771.2e-14Click!


Activity profile for motif Nr2c2.

activity profile for motif Nr2c2


Sorted Z-values histogram for motif Nr2c2

Sorted Z-values for motif Nr2c2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_120120138 15.443 ENSMUST00000112648.1
ENSMUST00000128408.1
Dbi

diazepam binding inhibitor

chr13_-_24761861 12.215 ENSMUST00000006898.3
ENSMUST00000110382.2
Gmnn

geminin

chr1_-_133424377 11.426 ENSMUST00000153799.1
Sox13
SRY-box containing gene 13
chr10_-_88146867 11.121 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr19_+_38395980 10.860 ENSMUST00000054098.2
Slc35g1
solute carrier family 35, member G1
chr6_-_95718800 9.912 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr1_+_191821444 8.795 ENSMUST00000027931.7
Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr7_+_79500081 8.747 ENSMUST00000181511.2
ENSMUST00000182937.1
AI854517

expressed sequence AI854517

chr10_+_84756055 8.627 ENSMUST00000060397.6
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr10_+_88146992 8.538 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr10_+_88147061 8.527 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr1_-_163289214 8.437 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr1_+_166254095 8.370 ENSMUST00000111416.1
Ildr2
immunoglobulin-like domain containing receptor 2
chr11_-_90002881 8.357 ENSMUST00000020864.8
Pctp
phosphatidylcholine transfer protein
chr17_-_56830916 8.287 ENSMUST00000002444.7
ENSMUST00000086801.5
Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr7_+_79500018 8.264 ENSMUST00000182495.1
ENSMUST00000183043.1
AI854517

expressed sequence AI854517

chr10_-_13324160 8.165 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr17_+_56303321 8.147 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr4_-_97778042 7.975 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr10_-_13324250 7.677 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 22.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
1.1 17.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
5.4 16.1 GO:0030421 defecation(GO:0030421)
0.1 14.7 GO:0051028 mRNA transport(GO:0051028)
0.2 13.8 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
1.7 11.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 11.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.0 11.4 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
1.6 11.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
3.6 10.9 GO:1990034 calcium ion export from cell(GO:1990034)
1.0 10.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 10.4 GO:0046033 AMP metabolic process(GO:0046033)
0.0 10.4 GO:0051301 cell division(GO:0051301)
1.1 9.9 GO:0006105 succinyl-CoA metabolic process(GO:0006104) succinate metabolic process(GO:0006105)
1.9 9.5 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.9 9.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 9.0 GO:0015914 phospholipid transport(GO:0015914)
1.1 8.9 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
2.2 8.8 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.4 8.7 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 36.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 24.3 GO:0031012 extracellular matrix(GO:0031012)
0.1 24.1 GO:0005667 transcription factor complex(GO:0005667)
0.8 22.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 21.0 GO:0000791 euchromatin(GO:0000791)
1.6 17.1 GO:0031080 nuclear pore outer ring(GO:0031080)
1.2 14.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.7 10.5 GO:0035686 sperm fibrous sheath(GO:0035686)
1.6 9.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 9.6 GO:0005681 spliceosomal complex(GO:0005681)
0.1 9.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 8.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 8.6 GO:0034707 chloride channel complex(GO:0034707)
0.3 7.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 7.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.8 7.5 GO:0061574 ASAP complex(GO:0061574)
0.5 7.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 7.4 GO:0005875 microtubule associated complex(GO:0005875)
0.1 6.9 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 6.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 32.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
5.5 22.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
5.1 15.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 14.8 GO:0070491 repressing transcription factor binding(GO:0070491)
4.6 13.7 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.3 12.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.1 11.6 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.2 11.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 11.2 GO:0003735 structural constituent of ribosome(GO:0003735)
1.7 10.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.8 9.6 GO:0034951 pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.2 9.6 GO:0016504 peptidase activator activity(GO:0016504)
0.1 9.6 GO:0001047 core promoter binding(GO:0001047)
0.1 9.3 GO:0008201 heparin binding(GO:0008201)
0.4 9.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 8.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 8.8 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 8.6 GO:0005254 chloride channel activity(GO:0005254)
1.4 8.4 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.3 8.4 GO:0071837 HMG box domain binding(GO:0071837)